Sepsisin Tanımı ve Sepsis İçin Yeni Biyobelirteçler

Year 2024, , 44 - 45, 01.03.2024

Abuzer Özkan

https://doi.org/10.38175/phnx.1362043

Abstract

Sepsis için spesifik bir biyobelirteç yoktur. Literatürde sepsisin tanımının belirsiz olduğu pek çok ideal biyobelirteç çalışması bulunmaktadır. Enfeksiyonu ayırt etmeye yönelik bir standart olmadığından sepsisi, özellikle bulaşıcı olmayan SIRS'den ayırmak zordur.

Keywords

sepsis, acil servis, yoğun bakım ünitesi

Definition of Sepsis and Novel Biomarkers for Sepsis

Abstract

There is no specific biomarker for sepsis. In the literature there are many ideal biomarker studies that the definition of sepsis is so vague. Since there is no standard for distinguishing infection, it is difficult to distinguish sepsis from SIRS that is especially non-infectious.

Keywords

sepsis, emergency services, intencive care unit

References

• Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644-55. doi: 10.1378/chest.101.6.1644.
• Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al; SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31(4):1250-6. doi: 10.1097/01.CCM.0000050454.01978.3B.
• Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10. doi: 10.1001/jama.2016.0287.
• Akoglu EU, Özdemir S, Ak R, Cimilli Öztürk T. The Discriminative Power of Inflammatory Markers in Patients with Mild-To-Moderate Acute Pancreatitis: Mean Platelet Volume, Neutrophil-Lymphocyte Ratio, Lymphocyte-Monocyte Ratio, and Neutrophil-Monocyte Product. South Clin Ist Euras 2021;32(2):159-64. doi: 10.14744/scie.2021.63626.
• Algın A, Özdemir S. Evaluation of the predictability of platelet mass index for short-term mortality in patients with COVID 19: a retrospective cohort study. J Contemp Med 2021;11(5):728- 33. doi: 10.16899/jcm.973825.
• Cox D. Sepsis - it is all about the platelets. Front Immunol. 2023;14:1210219. DOI: 10.3389/fimmu.2023.1210219.
• Özdemir S, Altunok İ, Eroğlu SE. Karbon monoksit zehirlenmesi laktat ve kardiyak belirteç ilişkisi. Van Tıp Derg. 2019;26(3): 285-8. doi: 10.5505/vtd.2019.24993.
• Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med. 2009;37(5):1670-7. doi: 10.1097/CCM.0b013e31819fcf68.
• Jekarl DW, Lee S, Kim M, Kim Y, Woo SH, Lee WJ. Procalcitonin as a prognostic marker for sepsis based on SEPSIS-3. J Clin Lab Anal. 2019;33(9):e22996. doi: 10.1002/jcla.22996.
• Bayram H, Tünger Ö, Çivi M, Yüceyar MH, Ulman C, Dinç H G, Çetin ÇB. Diagnostic and prognostic value of procalcitonin and sTREM-1 levels in sepsis. Turk J Med Sci. 2015;45(3):578-86.
• Özkan A, Sönmez E, Özdemir S, Özer ÖF, Muharrem N, Gülen B, Keskin M. The Diagnostic Value of SCUBE1 in Unstable Angina Pectoris Patients. Eurasian J Emerg Med. 2016;15:167-171. Doi: 10.5152/eajem.2016.83997.
• Sonmez E, Turkdogan KA, Karabacak M, Civelek C, Yilmaz C, Ozer OF, Çavuş UY. The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non–ST-elevation acute coronary syndrome. Am J Emerg Med 2015;33: 21-4. doi: 10.1016/j.ajem.2014.09.047.
• Erdoğan M, Findikli HA, Okuducu Teran İ. A novel biomarker for predicting sepsis mortality: SCUBE-1. Medicine (Baltimore). 2021;100(6):e24671. doi: 10.1097/MD.0000000000024671.
• Xiao H, Wang G, Wang Y, Tan Z, Sun X, Zhou J, et al. Potential Value of Presepsin Guidance in Shortening Antibiotic Therapy in Septic Patients: a Multicenter, Prospective Cohort Trial. Shock. 2022;57(1):63-71. doi: 10.1097/SHK.0000000000001870.
• Malkoç M, Kural B. Presepsin: Sepsis tespiti için umut verici yeni bir biyobelirteç. CBU-SBED. 2021; 8(3):553-7. doi: 10.34087/cbusbed.887818.
• Cavus UY, Yildirim S, Gurer B, Dibek K, Yilmaz D, Ozturk G, et al. The prognostic value of plasma Δ-copeptin levels in patients with isolated traumatic brain injury. Eur J Trauma Emerg Surg. 2014;40(3):373-8. doi: 10.1007/s00068-013-0357-4.
• Gomes DA, de Almeida Beltrão RL, de Oliveira Junior FM, Silva Junior JC, de Arruda EPC, Lira EC, da Rocha MJA. Vasopressin and copeptin release during sepsis and septic shock. Peptides. 2021;136:170437. doi: 10.1016/j.peptides.2020.170437.