Subklinik Hipotiroidinin Gebelik ve Yenidoğan Üzerine Etkisi

Abstract

Amaç: Yüksek TSH düzeyi ile birlikte normal serbest T4 düzeyine subklinik hipotiroidizm denir. Bu çalışmada olası yan etkiler açısından ilk trimesterde teşhis edilen subklinik hipotiroidi vakalarını araştırdık. Çalışma, gebelik sonuçlarını ve yenidoğan etkilerini göstermeyi amaçlamaktadır. Gereç ve Yöntem: Planladığımız çalışma tanılara dayalı olarak retrospektif olarak kayıt çalışması şeklinde yürütülmüştür. Üç hastane; bir şehir ve iki devlet hastanesi çalışmamıza dahil edildi. 2019-2021 yılları arasında bu merkezlerde tedavi gören gebeler dahil edilmiş, yenidoğan taramaları benzer şekilde pediatrik meslektaşlarımız tarafından dosyaların taranması şeklinde tanıya dayalı olarak yapılmıştır. Bulgular: Prematürite (p: 0,005), fetal ağırlık ve doğum haftası değerlendirildiğinde istatistiksel olarak anlamlı hale geldi. Çalışmaya katılan gebelerin T4 değerleri normal, TSH değerleri ≥ 2.5-4 mIU/L idi. Değerlendirme, erken doğumun istatistiksel olarak daha yüksek olduğunu ve fetal ağırlığın ve doğum haftasının önemli ölçüde daha düşük olduğunu gösterdi. Sonuç: Subklinik hipotiroidi tanısı alan gebelerde yapılan çalışmada erken doğum oranının kontrol grubuna göre daha yüksek olduğu ve doğum haftasının da kontrol grubuna göre daha düşük olduğu bulundu.

Keywords

• Gebelik
• Subklinik hipotiroidi
• Yenidoğan

Impact of Subclinical Hypothyroidism on Pregnancy and Newborn

Abstract

Objective: The normal free T4 level together with a high TSH level is called subclinical hypothyroidism. In this study, we investigated cases of subclinical hypothyroidism diagnosed in the first trimester for possible adverse effects. The study aims to show the pregnancy outcomes and neonatal effects. Material and Methods: The study we planned was conducted retrospectively as a record study based on diagnoses. Three hospitals; one city and two state hospitals, were included in our study. Pregnant women treated at these centers between 2019 and 2021 were included the screening of newborns was similarly performed by our pediatric colleagues, based on the diagnosis in the form of scanning the files. Results: It became statistically significant when prematurity (p: 0.005), fetal weight, and week of birth were evaluated. The T4 values of the pregnant women who taken part in the study were normal, and their TSH values were ≥ 2.5-4 mIU/L. The evaluation showed that preterm birth was statistically higher and fetal weight and week of birth were significantly lower. Conclusions: In the study of pregnant women diagnosed with subclinical hypothyroidism, it was found that the preterm delivery rate was higher than in the control group, and the delivery week was also lower than in the control group.

Keywords

• Pregnancy
• subclinical hypothyroidism
• newborn

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