A Rare Case: Herpes Simplex Encephalitis

Abstract

Herpes Simplex Encephalitis (HSE) is one of the most common causes of sporadic encephalitis and has the most mortal progression. A 22-year-old female patient applied to the emergency department with nausea and vomiting that lasted three days. The patient Cerebrospinal Fluid (CSF) was clear, the glucose ratio was low, and the protein ratio was high in the Lumbar Puncture (LP). HSV-DNA tests were requested with CSF culture and Polymerase Chain Reaction (PCR). Based on the LP results, and considering viral encephalitis, acyclovir treatment was started. The patient died on the 5th day while her treatment was continuing. HSV-DNA with PCR in BOS is the gold standard for the diagnosis of HSE. The most effective agent in treatment is acyclovir. The prognosis of the disease is poor.

Keywords

• Encephalitis
• herpes
• vomiting

Nadir Bir Olgu: Herpes Simpleks Ensefaliti

Abstract

Herpes Simplex Ensefaliti (HSE), sporadik ensefalitin sık nedenlerinden birisi ve en ölümcül seyredenidir. 22 yaşında kadın hasta, son üç gündür olan bulantı ve kusma şikayeti ile acil servise başvurdu. Lomber Ponksiyonda (LP) hastanın Beyin Omurilik Sıvısı (BOS) berrak görünümdeydi, glikoz oranı düşük ancak protein oranı yüksekti. BOS kültürü ve Polimeraz Zincir Reaksiyonu (PCR) ile HSV-DNA testleri istendi. LP sonuçları desteğinde viral ensefalit düşünülerek asiklovir tedavisi başlandı. Hasta 5. günde tedavisi devam ederken öldü. BOS'ta PCR ile HSV-DNA testi HSE teşhisi için altın standarttır. Tedavide en etkili ajan asiklovirdir. Hastalığın prognozu kötüdür.

Keywords

• Ensefalit
• Herpes
• Kusma

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