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Fluoxetine-Induced Reversible Galactorrhea and Hyperprolactinemia: A Case Report

Year 2021, , 44 - 45, 01.03.2021
https://doi.org/10.38175/phnx.817248

Abstract

Selective serotonin reuptake inhibitors can lead to increased prolactin levels and galactorrhea. Herein, we reported a 40-year-old female patient who developed galactorrhea and hyperprolactinemia two weeks after initiation of fluoxetine 20 mg/day. Galactorrhea was discontinued after the fifth week of fluoxetine withdrawal and prolactin levels reached normal limits. The patient's depressive symptoms disappeared with citalopram 40 mg/day and no similar side effects were observed during follow-up. Clinicians should be aware of the hyperprolactinemia and galactorrhea adverse effects of fluoxetine.

References

  • Majumdar A, Mangal NS. Hyperprolactinemia. J Hum Reprod Sci. 2013;6(3):168-175.
  • Malik AA, Aziz F, Beshyah SA, Aldahmani KM. Aetiologies of hyperprolactinaemia: A retrospective analysis from a tertiary healthcare centre. Sultan Qaboos Univ Med J. 2019 May;19(2):e129-e134.
  • Ajmal A, Joffe H, Nachtigall LB. Psychotropic-induced hyperprolactinemia: a clinical review. Psychosomatics. 2014;55(1):29-36.
  • Turkoglu S. Citalopram-induced galactorrhea in an adolescent. Clin Neuropharmacol. 2016;39(6):331.
  • Evrensel A, Önen Ünsalver B, Akyol A, Ceylan ME. A case of galactorrhea during paroxetine treatment. Int J Psychiatry Med. 2016;51(3):302-305.
  • Özten E, Hızlı-Sayar G, Göğcegöz-Gül I, Ceylan ME. Sertraline-induced galactorrhea. Arch Neuropsychiatr. 2015;52:202-203.
  • Peterson MC. Reversible galactorrhea and prolactin elevation related to fluoxetine use. Mayo Clin Proc. 2001;76:215-216.
  • Akdemir A, Örsel SD, Dağ İ, Türkçapar MH, İşcan N, Ozbay H. Hamilton depresyon derecelendirme ölçeği (HDDO)’nin geçerliliği-güvenilirliği ve klinikte kullanımı. Psikiyatri Psikoloji Psikofarmakoloji (3P) Dergisi. 1996;4(4):251-259.
  • Kose S, Akin E, Cetin M. Adverse drug reactions and causality: The Turkish version of Naranjo Adverse Drug Reactions Probability Scale. Psychiatr Clin Psychopharmacol. 2017;27(2):205-206.
  • Edwards IR, Biriell C. Harmonisation in pharmacovigilance. Drug Saf. 1994;10:93-102.
  • Mondal S, Saha I, Das S, Ganguly A, Das D, Tripathi SK. A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series. Ther Adv Psychopharmacol. 2013;3(6):322-334.
  • Chatterjee SS, Mitra S, Mallik N. Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine. Clin Psychopharmacol Neurosci. 2015;13(3):316-318.
  • Papakostas GI, Miller KK, Petersen T, Sklarsky KG, Hilliker SE, Klibanski A, Fava M. Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine. J Clin Psychiatry. 2006;67(6):952-957.

Fluoksetine Bağlı Geri Dönüşümlü Galaktore ve Hiperprolaktinemi: Bir Olgu Sunumu

Year 2021, , 44 - 45, 01.03.2021
https://doi.org/10.38175/phnx.817248

Abstract

Seçici serotonin geri alım inhibitörleri prolactin düzeyi yükselmesine ve galaktoreye yol açabilir. Burada, 20 mg/gün fluoksetin tedavisine başlandıktan iki hafta sonra galaktore ve hiperprolaktinemi gelişen 40 yaşında bir kadın hastayı sunduk. Fluoksetin kesilmesinin beşinci haftasından sonra galaktore kesildi ve prolaktin seviyeleri normal sınırlara ulaştı. Hastanın depresif semptomları sitalopram 40 mg/gün ile ortadan kalktı ve takipte benzer yan etkilere rastlanmadı. Klinisyenler, fluoksetinin hiperprolaktinemi ve galaktore yan etkilerine karşı uyanık olmalıdır.

References

  • Majumdar A, Mangal NS. Hyperprolactinemia. J Hum Reprod Sci. 2013;6(3):168-175.
  • Malik AA, Aziz F, Beshyah SA, Aldahmani KM. Aetiologies of hyperprolactinaemia: A retrospective analysis from a tertiary healthcare centre. Sultan Qaboos Univ Med J. 2019 May;19(2):e129-e134.
  • Ajmal A, Joffe H, Nachtigall LB. Psychotropic-induced hyperprolactinemia: a clinical review. Psychosomatics. 2014;55(1):29-36.
  • Turkoglu S. Citalopram-induced galactorrhea in an adolescent. Clin Neuropharmacol. 2016;39(6):331.
  • Evrensel A, Önen Ünsalver B, Akyol A, Ceylan ME. A case of galactorrhea during paroxetine treatment. Int J Psychiatry Med. 2016;51(3):302-305.
  • Özten E, Hızlı-Sayar G, Göğcegöz-Gül I, Ceylan ME. Sertraline-induced galactorrhea. Arch Neuropsychiatr. 2015;52:202-203.
  • Peterson MC. Reversible galactorrhea and prolactin elevation related to fluoxetine use. Mayo Clin Proc. 2001;76:215-216.
  • Akdemir A, Örsel SD, Dağ İ, Türkçapar MH, İşcan N, Ozbay H. Hamilton depresyon derecelendirme ölçeği (HDDO)’nin geçerliliği-güvenilirliği ve klinikte kullanımı. Psikiyatri Psikoloji Psikofarmakoloji (3P) Dergisi. 1996;4(4):251-259.
  • Kose S, Akin E, Cetin M. Adverse drug reactions and causality: The Turkish version of Naranjo Adverse Drug Reactions Probability Scale. Psychiatr Clin Psychopharmacol. 2017;27(2):205-206.
  • Edwards IR, Biriell C. Harmonisation in pharmacovigilance. Drug Saf. 1994;10:93-102.
  • Mondal S, Saha I, Das S, Ganguly A, Das D, Tripathi SK. A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series. Ther Adv Psychopharmacol. 2013;3(6):322-334.
  • Chatterjee SS, Mitra S, Mallik N. Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine. Clin Psychopharmacol Neurosci. 2015;13(3):316-318.
  • Papakostas GI, Miller KK, Petersen T, Sklarsky KG, Hilliker SE, Klibanski A, Fava M. Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine. J Clin Psychiatry. 2006;67(6):952-957.
There are 13 citations in total.

Details

Primary Language English
Subjects Psychiatry
Journal Section Case Reports
Authors

Mehmet Hamdi Örüm 0000-0002-4154-0738

Publication Date March 1, 2021
Submission Date October 27, 2020
Acceptance Date December 15, 2020
Published in Issue Year 2021

Cite

Vancouver Örüm MH. Fluoxetine-Induced Reversible Galactorrhea and Hyperprolactinemia: A Case Report. Phnx Med J. 2021;3(1):44-5.

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