The Relationship Between C-Reactive Protein Level, Disease Severity and Psoriatic Arthritis In Psoriasis Patients

Year 2020, Volume: 2 Issue: 2, 79 - 84, 01.07.2020

Şirin Çelik Nahide Onsun Alkım Çakıter Özlem Küçük Aylin Rezvani

https://doi.org/10.38175/phnx.658728

Abstract

Objective: This study aimed to determine the relationship between C-reactive protein psoriasis and psoriatic arthritis, which are in the group of Immune-Mediated Inflammatory Disease.
Materials and Methods: 201 psoriasis patients with or without psoriatic arthritis aged between 18-70 years and 98 healthy individuals aged between 18-70 years were included in the study. Psoriasis severity was calculated by psoriasis severity index, concurrent serum C - reactive protein level (by immunoturbidimetric latex method) was evaluated, and patients were evaluated for psoriatic arthritis in physical therapy and rehabilitation clinic. C - reactive protein levels between groups were compared. Correlation between C - reactive protein level and psoriasis severity index was evaluated in psoriasis patients.
Results: C - reactive protein levels were higher in psoriasis patients than the normal population (p <0.001), but there was no correlation between C - reactive protein level and psoriasis severity. C - reactive protein levels were higher in patients with active psoriatic arthritis compared to the control group (p <0.001) and psoriasis patients (p <0.001). In terms of C - reactive protein level values, no statistically significant difference was found between active psoriatic arthritis patients and inactive psoriatic arthritis patients (p = 0.449).
Conclusion: Although C - reactive protein level is higher in psoriasis patients compared to normal population, it is not correlated with disease severity, and therefore it is not useful to use psoriasis in the follow-up; however, we think that C - reactive protein level may be used in follow-up for psoriatic arthritis development in psoriasis patients. The fact that C - reactive protein level was not significantly different in active and inactive psoriatic arthritis patients, C - reactive protein level is not a sufficient indicator to assess whether psoriatic arthritis is active or inactive.

Keywords

Psoriasis, Psoriasis severity index, Psoriatic arthritis, C - reactive protein level

Psoriasis Hastalarında C-Reaktif Protein Düzeyinin Hastalık Şiddeti ve Psoriatik Artrit İle İlişkisi

Abstract

Amaç: Bu çalışmada “Immune Mediated Inflammatory Disease (İmmün Aracılı İltihabi Hastalık)” grubuna dâhil olan psoriasis ve psoriatik artritte, C-reaktif proteinin psoriasis şiddeti ve psoriatik artrit ile ilişkisini tespit etmek amaçlandı.
Gereç ve Yöntem: Çalışmaya 18-70 yaş arası psoriatik artriti olan veya olmayan toplam 201 psoriasis hastası ve kontrol grubu olarak 18-70 yaş arası 98 sağlıklı birey alındı. Psoriasis şiddeti psoriasis alan şiddet indeksi ile hesaplandı ve eşzamanlı serum C-Reaktif Protein düzeyi (immunoturbidimetric latex yöntemi ile) bakılıp hastalar fizik tedavi ve rehabilitasyon kliniğinde psoriatik artrit yönünden değerlendirildi. Gruplar arası C-Reaktif Protein düzeyleri karşılaştırıldı. Psoriasis hastalarında C-Reaktif Protein düzeyi ve psoriasis alan şiddet indeksi korelasyonuna bakıldı.
Bulgular: C-Reaktif Protein düzeyinin, psoriasis hastalarında normal popülasyona göre yüksek olduğu (p<0,001) ancak psoriasis şiddeti arasında korelasyon olmadığı saptandı (p=0,093) . C-Reaktif Protein değerleri, aktif psoriatik artrit hastalarında kontrol grubuna (p<0,001) ve psoriasis hastalarına (p<0,001) göre yüksek bulundu. C-Reaktif Protein değerleri açısından aktif psoriatik artrit hastaları ile inaktif psoriatik artrit hastaları arasında istatistiksel olarak anlamlı fark bulunmadı (p=0,449).
Sonuç: C-Reaktif Protein’in psoriasis hastalarında normal insanlara göre yüksek olmasına rağmen, hastalık şiddetiyle korele olmadığından, psoriasis şiddeti takibinde kullanımının yararlı olmayacağı; ancak psoriasis hastalarında psoriatik artrit gelişimi açısından takipte kullanılanılabileceğini düşünmekteyiz. Aktif ve inaktif psoriatik artrit hastalarında C-Reaktif Protein düzeyi açısından anlamlı fark saptanmaması, psoriatik artritin aktif veya inaktif dönemde olduğunu değerlendirmede tek başına yeterli bir belirteç olmadığı sonucunu doğurmaktadır. 

Keywords

Psoriasis, Psoriasis alan şiddet indeksi, Psoriatik artrit, C Reaktif Protein Seviyesi

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