Recent Advances in 4D Bioprinting

Abstract

Four-dimensional (4D) bioprinting, is generally accepted as the future of biofabrication technologies. 4D bioprinting develops dynamic and 3D based biological materials which can shift their shapes or alter their behaviors when several stimulants like electricity, temperature, humidity, magnetic etc. are applied. In this review, we highlighted the important aspects of several smart materials for 4D bioprinting that have been used recently for biofabrication researches. It is believed that in immediate future, smart materials and 4D Bioprinting techniques will have an excessive importance for designing of soft robotic systems and architecture of hierarchial, compex, thick and vascularized tissue structures

Keywords

• 4D Bioprinting
• 3D Bioprinting
• biofabrication
• tissue engineering
• smart materials

4B Biyobaskı Çalışmalarında Güncel Yenilikler

Abstract

Dört boyutlu (4B) biyobaskı tekniklerinin biyofabrikasyon teknolojilerinin geleceği olduğu düşünülmektedir. Elektrik, sıcaklık, nem, manyetik vs. gibi uyarıcılar aracılığı ile şekil değiştiren akıllı malzemeler kullanılarak ortaya çıkartılmış olan 4B biyobaskı tekniği, 3B biyolojik materyallerden oluşmuş ve zamanla şekil değiştirebilen yapılar üretilebilmektir. Bu mini derlemede bu alanda son yıllarda ortaya konmuş olan pek çok akıllı malzeme ve bunların önemleri açıklanmıştır. Akıllı malzemelerin ve 4B biyoyazıcı tekniklerinin çok yakın bir gelecek içerisinde yumuşak robotik sistemlerin tasarımlarında ve hiyerarşik, kompleks, kalın ve damar dokusu eklemlenmiş doku yapılarının tasarımlanmasında aşırı derecede önem kazanacağı düşünülmektedir.

Keywords

• 4B Biyobaskı
• 3B Biyobaskı
• Biyofabrikasyon
• Doku Mühendisliği
• Akıllı Malzemeler

References

1. [1] Shida Miao, Wei Zhu, Nathan J. Castro, Margaret Nowicki, Xuan Zhou, Haitao Cui, John P. Fisher, and Lijie Grace Zhang. (2016). 4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate. Sci. Rep. 6: 27226.
2. [2] Shida Miao, Wei Zhu, Nathan J. Castro, Jinsong Leng, and Lijie Grace Zhang. (2016). Four-dimensional printing hierarchy scaffolds with highly biocompatible smart polymers for tissue engineering applications. Tissue Eng Part C Methods 22(10): 952-963.
3. [3] Yong Qiu, Kinam Park, (2001). Environment-sensitive hydrogels for drug delivery. Adv. Drug Deliv. Rev. 53(3): 321-339.
4. [4] Ashammakhi, N., Ahadian, S., Zengjie, F., Suthiwanich, K., Lorestani, F., Orive, G., Khademhosseini, A. (2018). Advances and future perspectives in 4D bioprinting. Biotechnology journal, 13(12), 1800148.
5. [5] Li, Y. C., Zhang, Y. S., Akpek, A., Shin, S. R., & Khademhosseini, A. (2016). 4D bioprinting: the next-generation technology for biofabrication enabled by stimuli-responsive materials. Biofabrication, 9(1), 012001.
6. [6] Wilson, S. A., Cross, L. M., Peak, C. W., & Gaharwar, A. K. (2017). Shear-thinning and thermo-reversible nanoengineered inks for 3D bioprinting. ACS applied materials & interfaces, 9(50), 43449-43458.
7. [7] Chimene, D., Lennox, K. K., Kaunas, R. R., & Gaharwar, A. K. (2016). Advanced bioinks for 3D printing: a materials science perspective. Annals of biomedical engineering, 44(6), 2090-2102.
8. [8] Bishop, E. S., Mostafa, S., Pakvasa, M., Luu, H. H., Lee, M. J., Wolf, J. M., Reid, R. R. (2017). 3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends. Genes & diseases, 4(4), 185-195.

9. [9] Ke, D., Murphy, S.V. (2019). Current challenges of bioprinted tissues toward clinical translation. Tissue Engineering Part B: Reviews, 25(1), 1-13.
10. [10] Cheng X, Jin Y, Sun T, Qi R, Fan B and Li H. (2015). Oxidation-and thermo-responsive poly (N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogels cross-linked via diselenides for controlled drug delivery. RSC Advances. 5 4162-70
11. [11] Klouda L. (2015). Thermoresponsive hydrogels in biomedical applications: A seven-year update. European Journal of Pharmaceutics and Biopharmaceutics. 97, 338-49.
12. [12] Soledad Lencina M M, Iatridi Z, Villar M A and Tsitsilianis C. (2014). Thermoresponsive hydrogels from alginate-based graft copolymers. European Polymer Journal. 61, 33-44
13. [13] Bakarich S E, Gorkin R, 3rd, in het Panhuis M and Spinks G M. (2015). 4D Printing with Mechanically Robust, Thermally Actuating Hydrogels Macromol Rapid Commun, 36; 1211-1217
14. [14] Han, D., Lu, Z., Chester, S. A., & Lee, H. (2018). Micro 3D printing of a temperature-responsive hydrogel using projection micro-stereolithography. Scientific reports, 8(1), 1-10.
15. [15] Liu J, Erol O, Pantula A, Liu W, Jiang Z, Kobayashi K, Chatterjee D, Hibino N, Romer L.H. and Kang S.H. (2019). Dual-Gel 4D Printing of Bioinspired Tubes. ACS applied materials & interfaces, 11; 8492-8
16. [16] Hsieh F.Y, Lin H.H. and Hsu S.H., (2015). 3D bioprinting of neural stem cell-laden thermoresponsive biodegradable polyurethane hydrogel and potential in central nervous system repair Biomaterials, 71; 48-57.
17. [17] Mellati A, Fan C M, Tamayol A, Annabi N, Dai S, Bi J, Jin B, Xian C, Khademhosseini A and Zhang H, (2017). Microengineered 3D cell‐laden thermoresponsive hydrogels for mimicking cell morphology and orientation in cartilage tissue engineering Biotechnology and bioengineering 114, 217-31.
18. [18] Lv C, Sun X.C, Xia H, Yu Y.H, Wang G, Cao X.W, Li S.X, Wang Y.S, Chen Q.D, Yu Y.D and Sun H.B. (2018). Humidity-responsive actuation of programmable hydrogel microstructures based on 3D printing Sensors and Actuators B: Chemical, 259; 736-44.
19. [19] Zhang L, Liang H, Jacob J and Naumov P. (2015). Photogated humidity-driven motility. Nature communications, 6; 7429.
20. [20] Ashammakhi N, Ahadian S, Zengjie F, Suthiwanich K, Lorestani F, Orive G, Ostrovidov S and Khademhosseini A. (2018). Advances and Future Perspectives in 4D Bioprinting Biotechnol J. 13, 1800148
21. [21] Yang, H., Leow W.R., Wang T., Yu J., He K., Qi D., Wan C., Chen X. (2017). 3D printed photoresponsive devices based on shape memory composites. Advanced Materials, 29(33): p. 1701627.
22. [22] Cui, H.T., Miao S., Esworthy T., Lee S.J., Zhou X., Hann S.Y., Webster T.J., Harris B.T., Zhang L.G., (2019). A novel near-infrared light responsive 4D printed nanoarchitecture with dynamically and remotely controllable transformation. Nano Research,. 12(6): p. 1381-1388.
23. [23] Gupta, M.K., Meng F., Johnson B.N., Kong Y.L., Tian L, Yeh Y.W., Masters N., Singamameni S., McAlpine M.C. (2015). 3D printed programmable release capsules. Nano letters, 15(8): p. 5321-5329.
24. [24] Tamay, D.G., Usal T.D., Alagöz A.S., Yücel D., Hasırcı N, Hasırcı V. (2019). 3D and 4D Printing of Polymers for Tissue Engineering Applications. Frontiers in Bioengineering and Biotechnology,. 7.
25. [25] Wei, H.Q., Zhang Q., Yao Y., Liu L., Liu Y., Leng J., (2017). Direct-Write Fabrication of 4D Active Shape-Changing Structures Based on a Shape Memory Polymer and Its Nanocomposite. Acs Applied Materials & Interfaces,. 9(1): p. 876-883.
26. [26] Zhu, P.F., Yang W., Wang R., Gao S., Li B., Li Q., (2018). 4D Printing of Complex Structures with a Fast Response Time to Magnetic Stimulus. Acs Applied Materials & Interfaces,. 10(42): p. 36435-36442.
27. [27] Cvetkovic, C., Raman R., Chan V., Williams B.J., Tolish M., Bajaj P., Sakar M.S., Asada H.H., Saif M.T.A., Bashir R. (2014). Three-dimensionally printed biological machines powered by skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 111(28): p. 10125-10130.
28. [28] Sayyar, S., Bjorninen M., Haimi S., Miettinen S., Gilmore K., Grijpma D., Wallace G. (2016). UV cross-linkable graphene/poly (trimethylene carbonate) composites for 3D printing of electrically conductive scaffolds. ACS applied materials & interfaces,. 8(46): p. 31916-31925.
29. [29] Liu, W., Heinrich, M. A., Zhou, Y., Akpek, A., Hu, N., Liu, X., Zhang, Y.S. (2017). Extrusion bioprinting of shear‐thinning gelatin methacryloyl bioinks. Advanced healthcare materials, 6(12), 1601451.
30. [30] Heinrich, M. A., Liu, W., Jimenez, A., Yang, J., Akpek, A., Liu, X., Prakash, (2019). J. 3D bioprinting: from benches to translational applications. Small, 15(23), 1805510.
31. [31] Avci, H., Doğan Güzel, F., Erol, S., Akpek, (2018). A. Recent advances in organ-on-a-chip technologies and future challenges: a review. Turkish Journal of Chemistry, 42(3).
32. [32] Kizilkurtlu, A. A., Polat, T., Aydin, G.B., Akpek, (2018). A. Lung on a chip for drug screening and design. Current Pharmaceutical Design, 24(45), 5386-5396.
33. [33] Akpek, A. (2018). Triküspit kalp kapakçıklarının üç boyutlu (3B) biyobaskı metotları ile fabrikasyonu. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 22(2), 740-745.
34. [34] Wei, W., Li, Y., Yang, H., Nassab, R., Shahriyari, F., Akpek, A., Zhang, Y.S. (2017). 3D Printed Anchoring Sutures for Permanent Shaping of Tissues. Macromolecular bioscience, 17(12), 1700304.
35. [35] Akpek, A. (2018). Analysis of biocompatibility characteristics of stereolithography applied three dimensional (3D) bioprinted artifical heart valves. Journal of the Faculty of Engineering and Architecture of Gazi University, 33(3), 929-938.