The Effects of Opium Seed Oil Massage on Oxidant-Antioxidant Status and Biochemical Parameters

Year 2024, Volume: 26 Issue: 4, 187 - 196, 25.12.2024

Yücel Ocak , Abdurrahman Fatih Fidan , Ümit Dündar , Sebiha Gölünük Başpınar , Mürüvvet Kurt

https://doi.org/10.62425/rses.1489665

Abstract

In this study, it was aimed to examine the effects of oxidant-antioxidant status and massage applicati on swith opium oil on some blood values. After the study, the question of whether opium oil can be used as aromatrapic massage oil was sought to be answered. Necessary permissions were obtained before the research. Thirty healthy women between the ages of 18-25 participated in thestudy. Participants in the study were applied as liquid (10 people) Vaseline (10 people) and the control group (10 people) for 8 weeks, 3 days a week for an average of 30-40 minutes. The fatty acids of the opium oil to be used before the massage were analyzed. Blood was drawn forthe 4th time from the participants in all groups: 1 day before and after the 1st session in the 1st week, after 12 sessions in the 4th week, and after the 24th session in the 8th week. Biochemical, hematological parameters, DNA damage, andsome vitamin values were analyzed from blood samples. Covariance analysis was used by making normality distribution in statistical analysis. Tukey-Kramer test was used for group differences. The level of significance was set at p 0.05. There were statistically significant differences in biochemical and hematological values between the groups (p <0.05). As a result, it has been observed that massage with opium oil increases HDL values and increases the Dopamine hormone. it was seen that it caused a significant decrease in WBC, MPV and Basophil level samong hematological parameters, significantly decreased the MDA level in the Vaseline group, and the massage application with petroleum jelly significantly reduced the level of DNA damage. New research is needed to use opium oil as a massage oil.

Keywords

Opium oil, Massage, Aroma therapy, Hematology, Treatment, Oxidative stres

Ethical Statement

This study has not been published elsewhere. there is no conflict of interest. All applicable standards of experimental and research ethics have been met, and we declare that there are no concerns about duplicate publication, fraud, plagiarism or human experimentation.

Supporting Institution

This study was supported within the scope of Afyon Kocatepe University Scientific research projects Commission with the ID number 17.TEMATİK.06.

Project Number

Afyon Kocatepe University Scientific research projects Commission with the ID number 17.TEMATİK.06.

References

• Angelia, S R, Manikam N R M, Lubis A M T, Siagian C, Mudjihartini N. (2019). Association Between the Ratio of Omega-6/Omega-3 Fatty Acids Intake to Plasma Malondialdehyde Level in Patients with Knee Osteoarthritis. Earth Environ. Sci. 217 012055
• Arslan, N. (2009). Haşhaş: Türkiye bitkilerinin simgesi. Gıda Hattı, 22, 68-69.
• Arslan, N., Büyükgöçmen, R., & Gümüşçü, A. (2000). Oil and morphin econtents of Turkish opium populations. Tarla Bitkileri Merkez Araştırma Enstitüsü Dergisi, 9(1-2)
• Azcan, N., Kalender, B. O., & Kara, M. (2004). Investigation of Turkish opium seed sand seed oils. Chemistry of Natural Compounds, 40(4), 370-372.
• Bello A (2001). Hematología básica. Prado.
• Bernath, J., (1998). Opium, The Genus Papaver. Harwood Academic Publisher, Amsterdam, The Netherlands.
• Calder, P. C. 2012 Mechanisms of Action of (n-3) FattyAcids. J Nutr. 142 3 592S-599S
• Çetin, Ş., & Bek, Y. (2019). Tekrarlanan Ölçümlü Verilerde Kovaryans Modelleri. Türkiye Klinikleri Biyoistatistik, 11(3), 239-253.
• Field, T, Hernandez-Reif, M, Diego, et al. (2005) Cortisol decreases and serotonin and dopamine in crease following massage therapy. Int J Neurosci, 115(10): 1397– 1413.
• Firkins, J. L., Eastridge, M. L., St-Pierre, N. R., & Noftsger, S. M. (2001). Effects of grain variability and processing on starch utilization by lactating dairy cattle. Journal of animal science, 79(suppl_E), E218-E238. https://doi.org/10.3390/nu8030128,
• Kapoor, L. (2020). Opium poppy: botany, chemistry, and pharmacology. CRC Press..
• Karabulut, A. B., Kafkas, M. E., Kafkas, A. S., Onal, Y., & Kiran, T. R. (2013). The effect of regular exercise and massage on oxidantand antioxidant parameters. Indian J Physiol Pharmacol, 57(4), 378-383.
• Kızılarslanoğlu, M. C.,& Güven, G. S. (2011). Düşük HDL kolesterol düzeyine yaklaşım nasıl olmalıdır. Hacettepe Tıp Dergisi, 42, 196-201.
• Mukhoirotin, K. (2020). The Effect of Slow Stroke Back Massage, Cold-compressand Warm-compress on Superokside Dismutaseand Malondialdehyde Levels in Primary Dysmenorrhoea. Medico Legal Update, 20(1), 2299-2304.
• Özkan, G, Baydar, N. (2006). A Direct RP-HPLC Determination of Phenolic Compounds in Turkish Red Wines. Akdeniz Üniversitesi Ziraat Fakültesi Dergisi, 19 (2), 229-234.
• Patterson, E., Wall, R., Fitzgerald, G. F., Ross, R. P., Stanton C. (2012). Healt himplications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab, 539426
• Sakata, S., Hayashi, S., Fujishiro, T., Kawakita, K., Kanzaki, N., Hashimoto, S., et al. (2015). Oxidative stress-induced apoptosis and matrixloss of chondrocytes is inhibited bye icosapentaenoic acid. J Orthop Res. 33 3 359–365
• Sies, H. (1991). Oxidative stress: from basic research to clinical application. Am J Med; 91(suppl3C):30-8.
• Simopoulos, A. P. (2016). An Increase in the Omega-6/Omega-3 FattyAcidRatioIncreasesthe Risk for Obesity Nutrients, 8 128.
• Simopoulos, A.P. (2008). The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 233:674-88.
• Singh, S.P., Shukla, S., Khanna, K.R., Dixit, B.S., Banerji, R.O., (1998). Variation of major fatty acids in generation of opium opium (Papaver somniferum _ Papaver setigerum) genotypes. J. Sci. Food Agric. 76,168–172.
• Tayyebi-Khosroshahi, H.,Houshyar, J., Tabrizi, A., Vatankhah, A. M., Razzagi, Z. N., Dehghan-Hesari, R. (2010). Effect of omega-3 fatty acid on oxidative stress in patients on hemodialysis. Iran J Kidney Dis (4) 4 322–326.
• Tourtas, T., Kopsachilis, N., Kruse, F. E., Welge-Lüssen, U., & Birke, K. (2011). The Antioxidative Effect of Omega-3 and Omega-6 Fatty Acids in Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science, 52(14), 4664-4664.
• Turan H, Erkoyuncu İ, Kocatepe D. (2013). Omega-6, omega-3 yağ asitleri ve balık. Yunus Araştırma Bülteni. 2, 45-50.
• Veiskaramian, A., Gholami, M., Yarahmadi, S., Baharvand, P. A., & Birjandi, M. (2021). Effect of aromatherapy with Melissa essential oil on stress and hemodynamic parameters in acute coronary syndrome patients: A clinical trial in the emergency department. Complementary Therapies in Clinical Practice, 44, 101436.
• Watkins, B.A. (1991). Importance of essential fatty acids and their derivatives in poultry, J Nutr 121:1475-85.5
• Yang, L. G.,Song, Z. X., Yin, H., Wang, Y. Y., Shu, G. F., Lu, H. X., et al. (2016) Low n-6/n-3 PUFA Ratio Improves Lipid Metabolism, Inflammation, Oxidative Stressand Endothelial Function in Rats Using Plant Oils as n-3 Fatty Acid Source Lipids, 51 1 49–59.