Sert Doku Uygulamaları İçin Makro Gözenekli Alüminyum Oksit-Bor Karbür Seramikleri

Year 2023, , 65 - 75, 31.12.2023

Kerim Emre Öksüz

https://doi.org/10.53501/rteufemud.1293580

Cited By: 1

Abstract

Bu çalışma, dünya çapında yaygın bir klinik problem olan sert doku defektlerinin tedavisi için yüksek kaliteli biyoseramik köpüklerin geliştirilmesine odaklanmaktadır. Bu deneysel çalışmada, biyomedikal alanlarda kullanılması hedeflenen karbür (B4C) ilaveli α-alüminyum oksit (Al2O3) seramikler replika yöntemi ile yüksek gözenekli olarak üretilmiş ve karakterize edilmiştir. Ekonomik polimer model malzeme olarak kullanılan açık gözenekli, 30 ppi gözenek boyutunda poliüretan süngerlerin termogravimetrik (TGA) ve diferansiyel termal analizleri (DTA) ile termal özelikleri belirlenmiştir. Yüksek sıcaklıkta sinterlenerek elde edilen, farklı B4C oranları içeren Al2O3 esaslı seramik köpükler homojen, yüksek gözenekli ve birleştirici gözenek mikroyapısında olduğu yüksek alan emisyon tabancalı taramalı elektron mikroskobu (FEG-SEM) ile detaylı olarak incelenmiştir. X-ışınları (XRD) analizleri ile B4C’nin yapı içerisinde varlığı ve faz değişimleri doğrulanmıştır. Yapısında ağırlıkça % 0, % 3 ve % 5 B4C içeren sinterlenmiş seramik köpüklerin basma mukavemeti değerleri sırasıyla 1,92 MPa, 2,05 MPa ve 2,38 Mpa olarak ölçülmüştür. Canlı ortamlarda kullanılacak biyomalzemelerin oluşturacağı biyolojik cevabın önceden değerlendirilmesi amacıyla yapılan in vitro testlerde tatmin edici sonuçlar elde edilmiştir. Hücre canlılığı deneyleri, Al2O3 esaslı seramik köpüklere B4C ilavesinin sert doku defektlerinde önemli bir avantaj olan hücre proliferasyonunu desteklediğini göstermiştir.

Keywords

Al2O3, B4C, Makro gözenek, In vitro, Mikroyapı

Thanks

Acknowledgement I would like to extend my sincere gratitude to Dr. Ceylan HEPOKUR, a respected faculty member of the Faculty of Pharmacy, for her generous assistance with the in vitro tests conducted in this study. Her expertise and support have been instrumental in the success of this research, and I am truly grateful for her contributions.

Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications

Abstract

This paper focuses on the development of high-quality bioceramic foams for the treatment of hard tissue defects, which are a widespread clinical problem worldwide. In this experimental study, α-alumina (Al2O3) ceramics with boron carbide (B4C) additives, intended for use in biomedical applications, were produced and characterized as highly porous using the replication method. The thermal properties of open-pore polyurethane sponges, with a pore size of 20 ppi, used as an economical polymer model material, were determined by thermo-gravimetric (TGA) and differential thermal analysis (DTA). Ceramic foams based on Al2O3, with varying B4C ratios, were obtained by high-temperature sintering and were thoroughly examined using high-resolution field emission scanning electron microscopy (FEG-SEM) for homogeneity, high porosity, and interconnected pore microstructure. X-ray diffraction (XRD) analyses confirmed the presence of B4C within the structure and phase changes. The compressive strength values of sintered ceramic foams containing 0%, 3%, and 5% B4C by weight were measured as 1.92 MPa, 2.05 MPa, and 2.38 MPa, respectively. In vitro tests were performed to evaluate the biological response that biomaterials intended for use in living environments would produce. Satisfactory results were obtained from cell viability experiments, demonstrating that the addition of B4C to Al2O3-based ceramic foams supports cell proliferation, which is an important advantage in hard tissue defect treatment.

Keywords

Al2O3, B4C, Ceramic foam, In vitro, Macro porous, Microstructure

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