Formation Mechanism of Fumonisins and Results of Subacute and Chronic Effects on Metabolism

Year 2022, Volume: 3 Issue: 2, 115 - 124, 30.12.2022

Pınar Kar

https://doi.org/10.53501/rteufemud.1109901

Abstract

Molds are microscopic fungi that live on plants and animals that threaten the health of many living things. Fungi form spores and form mold by being carried by air, water and insects. Mold contamination is in the first place especially in regions with high temperature and humid climate. It shows that molds can multiply when suitable conditions are met. Molds, one is economical and the other is dangerous in terms of creating mycotoxins. To date, more than 400 mycotoxin species have been found in studies, and only 20 of them have been proven to have high affinity for humans and animals. The most common Mycotoxins are cyclopiazonic acid, ochratoxin, patulin, aflatoxin (AF), trichothecenes, zeranol, and fumonisin. The most common type in nature is fumonisins. Fumanosine species have subacute and chronic effects on many living things. Mainly Liver cancer, Muscle cramps, Poor nutrient absorption, Bone resorption, Diarrhea, Trouble in breathing, paralysis, vomiting, epilepsy, stomach pain, weak immune system, chills, joint pains, weak pulse, tremor, hand and foot It is the leading cause of many diseases such as lethargy, rheumatism, Parkinson's disease, MS (multiple sclerosis). It is thought that the presence of these toxins, which have negative effects on health, can be prevented if adequate and necessary precautions are taken. In this study, it was compiled in order to explain the chemical structure, formation mechanism and the results of their effects on health.

Keywords

mycotoxin, contamination, parkinson, multıple skleroz

Fumonisinlerin Oluşum Mekanizması ve Metabolizmada Subakut, Kronik Etkisinin Sonuçları

Abstract

Küfler birçok canlının sağlığını tehdit eden bitki ve hayvanlar üzerinde yaşayan mikroskobik mantarlardır. Mantarlar spor oluşturarak hava su, böcekler yoluyla taşınarak küf oluştururlar. Küf kontaminasyonu özellikle yüksek sıcaklık ve nemli iklime sahip olduğu bölgelerde ilk sıradadır. Küfler uygun şartları sağladığında çoğalabileceğini göstermektedir. Küfler biri ekonomik diğeri ise mikotoksin oluşturma açısından tehlikelidir. Günümüze kadar 400'den fazla mikotoksin türü olduğu çalışmalarla bulunmuş ve içlerinde sadece 20 mikotoksin insan ve hayvanlar için yüksek affiniteye sahip olduğu kanıtlanmıştır. En sık karşılaşılan Mikotoksinler siklopiazonik asit, okratoksin, patulin, aflatoksin (AF), trikotesenler, zeranol, ve fumonisin olarak çeşitlenmektedir. Doğada en çok karşılaşılan türü fumonisinlerdir. Fumanosin türleri birçok canlı üzerinde subakut ve kronik etkileri bulunmaktadır. Başta Karaciğer kanseri, Kas krampları, Zayıf besin emilimi, Kemik erimeleri, İshal, Nefes alış- verişlerde sıkıntı, felce uğratma, kusma, sara, mide ağrısı, , zayıf bağışıklık sistemi, üşüme, eklem ağrıları, nabız zayıflığı, titreme, el ve ayakta uyuşukluk, romatizma, parkinson hastalığı, MS (multiple skleroz), gibi birçok hastalığın öncül sebebidir. Sağlık üzerine olumsuz etkileri olan bu toksinlerin varlığının yeterli ve gerekli önlem verildiğinde önüne geçilebileceği düşünülmektedir. Bu çalışmada Fumanosinlerin kimyasal yapısını, oluşum mekanizmasını, sağlık üzerine etkilerinin sonuçlarını açıklamak amacıyla derlenmiştir.

Keywords

mikotoksin, kontaminasyon, parkinson, multıple skleroz

Supporting Institution

ONDOKUZMAYIS ÜNİVERSİTESİ VETERİNER FAKÜLTESİ BİYOKİMYA ABD.

References

• 1. Blackwell, B.A., Edwards, O.E., Fruchier, A., ApSimon, J.W., Miller, J.D., (1996). NMR structural studies of fumonisin B1 and related compounds from Fusarium moniliforme. Advances
• 2. Bennett JW, Klich M (2003). Mycotoxins. Clinical Microbiology Reviews, Vol 16, No 3: 497-516.
• 3. Bezuıdenhout, S.C., Gelderblom, W.C.A., Gorst-Allman, C.P.,Horak, R.M., Marasas, W.F.O., Spıteller, G., Vleggaar, R. (1988) Structure Elucidation Of The Fumonisins, Mycotoxins From Fusarium Moniliforme.J. Chem. Soc. Chem. Commun., 1988:743-745.
• 4. Büyükşirin, S. (1993) Kuru İncirlerde Küf Florası Ve Aflatoksijenik Küflerin Saptanması, (Yüksek Lisans Tezi), İzmir Ege Üniversitesi Fen Edebiyat Fakültesi, Türkiye
• 5. Cawood, M.E., Gelderblom, W.C., Vleggaar, R., Behrend, Y., Thıel, P.G., Marasas W.F. (1991). Isolation Of The Fumonisin Mycotoxins: A Quantitative Approach, J. Agricul. Food Chem. 39: 1958- 1962.
• 6. Collins, T.F.X., Shackelford, M.E., Sprando, R.L., Black, T.N., Laborde, J.B., Hansen, D.K., Eppley, RM., Trucksess, M.W., Howard, P.c., Bryant, M.A., Ruggles, DJ., Olejnik, N., Rorie, J.1. (1998a). Effects of fumonisin B 1 in pregnant rats. Food Chem Toxİcol, 36, 397-408.
• 7. Evren M (1999). Aflatoksinlerin Etki Şekilleri, Gıdalarda Bulunma Durumları ve Önleme Çareleri. O.M.Ü. Ziraat Fakültesi Dergisi, Cilt:14, Sayı:2, Samsun.
• 8. Derici, B. , (1997). Kuru İncirlerde Aflatoksin ve Okratoksin A Oluşumunun Bazı Besin Maddeleri ile İlişkileri Üzerinde Araştırmalar, (Yüksek Lisans Tezi), İzmir Ege Üniversitesi Fen Bilimleri Enstitüsü, Bahçe Bitkileri Anabilim Dalı, Türkiye
• 9. Dombrınk-kutzman, M.A., Dvorak, t.j.(1999). Fumonisin content in masa and tortillas from mexico. j.agri.food chem. 47: 622-627
• 10. 10.Harvey, R.B., Edrıngton, T.S.., Kubena, I.K., Elıssalde, M.H., Casper, H.H., Rottınghaus, G.E., turk, J.R. (1996). effects of dietary fumonisin b1-containing culture material, deoxynivalenol- contaminated wheat, or their combination on growing barrows. am. j. vet. res., 57: 1790 –1794.
• 11. 11.Hussein, H. ; Brasel, J. (2001). Toxicity, metabolism and impact of mycotoxins on human and animals. Toxicology, 167, 101–134.
• 12. Humpf H, Voss KA (2004). Effects of thermal food processing on the chemical structure and toxicity of fumonisin mycotoxins. Mol. Nutr. Food Res., 48, 255-269.
• 13. Hoye, T.R., Jımenez, J.I., Shıer, W.T. (1994) Relative And Absolute Configuration Of The Fumonisin B1 Backbone. J. Am. Chem. Soc., 116, 9409–9410.
• 14. Galvano, F., Russo, A, Cardile, V., Galvano, G., Vanella, A, Renis, M. (2002). DNA damage in human fibroblasts exposed to fumonisin Bl. Food Chem Toxicol, 40, 25-31.
• 15. Gbore, F.A., Egbunike, G.N., (2008). Testicular and epididymal sperm reserves and sperm production of pubertal boars fed dietary fumonisin B1. Animal Reproduction Science 105 392–397.
• 16. Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., Thiel, P.G., Horak, R. M., Vleggaar, R., Kriek, N.P., (1988) Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Applied and Environmental Microbiology 54, 1806-1811.
• 17. Kamle M, Mahato DK, Devi S, Lee KE, Kang SG, Kumar P (2019). Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies. Toxins, 11(6), 328.
• 18. Kaya S. Mikotoksinler. In: Kaya S ed. Veteriner Toksikoloji, 3. Baskı. Medisan Yayınevi. 2014.p.393-433; Ankara
• 19. Kriek, N.P.J., Kellerman, T.S., Marasas, W.F.O., (1981) A comparative study of the toxicity of Fusarium verticillioides (= F. moniliforme) to horses, primates, pigs, sheep and rats. Onderstepoort Journal of Veterinary Research 48, 129-131.
• 20. Leeson, S., Dıaz, G., Summers, J.D. (1995). Fumonisins İn “Poultry Metabolic Disorders And Mycotoxins”. University Books. P.:299-309. Guelp, Canada
• 21. Marasas, W.F.O., Wehner, F.C., Van Rensburg, S.J., D. J. van Schalkwyk., (1980) Mycoflora of corn produced in human esophageal cancer areas in Transkei, Southern Africa. Phytopathology 71, 792- 796.
• 22. Marin, S., Ramos, A.J., Cano-Sancho, G., Sanchis, V., (2013) Mycotoxins: Occurrence, toxicology, and exposure assessment. Food and Chemical Toxicology 60, 218–237.
• 23. Martins ML, Martins HM, Bernardo F (2001). Fumonisins B1 and B2 in black tea and medicinal plants. J. Food Prot., 64, 8, 1268-1270.
• 24. Merrill J.R., A.H., Sullards, M.C., Wang, E., Voss, K.A., Riley, R.T., (2001). Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. Environ. Health Persp. 109 (Suppl. 2), 283–289.
• 25. Musser, S.M., and Plattner, O.R., (1997). Fumonisin composition in cultures of fusarium moniliforme, Fusarium proliferatum and fusarium nygamia J.Agric. Food Chem. 45:4,1169-1173
• 26. Móricz AM, Fatér Z, Otta KH, Tyihák E, Mincsovics E. (2007). Overpressured layer chromatographic determination of aflatoxin B1 , B2 , G1 and G2 in red paprika. Microchem J, 85 (1): 140–4.
• 27. Naır, M.G. (1998). Fumonisins and human health. Annals of Tropical Paediatrics. 18: 47 –52.
• 28. Nelson ,P.E., Desjardıns, A., E., and plattner, R.D. (1993). Fumonisins, mycotoxins prodüced by fusarium species; Biology , chemistry and signifinance. Annu. Rev. Pytopathol., 311: 233-252.
• 29. Norred, W.P., Voss, K.A., Riley, R.T.,(1998). Mycotoxins and health hazards: toxicological aspects and mechanism of action of fumonisins. The Journal of Toxicological Sciences, 23, 160- 164.
• 30. 30.Prelusky, D.B., Savard, M.E., Trenholm, H.L.(1995). Pilot study on the plasma pharmacokinetics of fumonisin B 1 in cows following a single dose by oral gavage or intravenous administration. Nat Toxins, 3(5), 389-394.
• 31. Prelusky, D.B., Trenholm, H.L., Savard, M.E.(1994). Pharmacokinetic fate of 14C-Iabelled fumonisin B 1 in swine. Nat Toxins, 2(2), 73-80.
• 32. Pitt JI, Wild CP, Baan RA, Gelderblom WCA, Miller JD, Riley RT, Wu F (2012). Improving public health through mycotoxin control. Lyon: IARC Scientific Publication No. 158, p:1-30.
• 33. Rıley, R.T., Norred, W.P., Bacon, C.W.(1993). Fungal Toxins İn Food: Recent Concerns. Ann.Rev.Nutr. 13: 167-189.
• 34. Salem NM, Ahmad R. (2010). Mycotoxins in food from Jordan: Preliminary survey. Food Control, 21 (8): 1099–103.
• 35. Salwa MH, Hegazi SM, Demet O, Oguz H. Comparative study on the influence of aflatoxin and ochratoxin performance of broilerchicks. J Egypt Vet Med Ass 2000;60: 201-12.
• 36. Seo. J.A., KIM.J.C., and LEE, Y. W. (1996). Isolatıon and characterization of two New Type C Fumonisins Prodüced by F. Oxysporum. Journal of Natural Prodücts V: 59 No: 11 November 1003- 1005
• 37. Scott, P.M., (1993). Fumonisins. International Journal of Food Microbiology 18(4), 257-270.
• 38. Sweeney, M.J., Dobson, A-D.W., (1998). Mycotoxin production by Aspergillus. Fusarium and Penicillium Species. International Journal ofFood Microbiology., 43: 141-IS8.
• 39. Steyn PS, Stander MA. (1999). Mycotoxins with Special Reference to the Carcinogenic Mycotoxins: Aflatoxins, Ochratoxins and Fumonisins. In: Ballantyne B, Marrs TC, Syversen TLM, eds. 1999.General and Applied Toxicology. 2nd Edition. United Kingdom: Macmillan Reference Ltd, 2145-76.
• 40. Susca, A., Proctor, R.H., Mule, G., Stea, G., Ritieni, A., Logrieco, A. ve Moretti, A. (2010). Correlation of Mycotoxin Fumonisin B2 Production and Presence of the Fumonisin Biosynthetic Gene fum8 in Aspergillus niger from Grape, Journal of Agricultural and Food Chemistry, 58, 9266-9272.
• 41. Stockmann-Juvala, H., Savolainen, K.,(2008). A review of the toxic effects and mechanisms of action of fumonisin B1. Human & Experimental Toxicology 27, 799–809.
• 42. Şahin T, Şehu A. Yemlerde mikotoksinler ve toksinleri azaltma yolları. Türkiye Klinikleri J Anim Nutr and Nutr Dis-Special Topics 2015;1(1):54-65
• 43. Şener S. (2006). Gıda güvenliği açısından mikotoksinler. Türkiye Klinikleri J Surg Med Sci, 2 (46): 135–9.
• 44. Topal Ş. , Aran N. , Pembeci C. , (1999). Türkiye’nin tarımsal mikroflorasının mikotoksin profilleri, Gıda, 24 (2), 129-137
• 45. 43.Waśkiewicz, A., Beszterda, M., Goliński, P., (2012). Occurrence of fumonisins in food - an interdisciplinary approach to the problem. Food Control 26, 491-499.
• 46. Wang, E., Norred, W.p., Bacon, C.W., Riley, R.T., Merrili, A.H. Jr (1991). Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforrne. Biol Chem, 266(22), 14486-14490.
• 47. Van Egmond HP, (1983) Mycotoxins in dairy product. Food Chemistry, 11, 289-307
• 48. Zinedine, A. ,González-Osnaya, L. , Soriano, J.M., Moltó, J.C., Idrissi, L., Mañes, J. (2007) Presence of aflatoxin M1 in pasteurized milk from Morocco. Int. J. Food Microbiol 114, 25–9
• 49. Zomborszky-Kovacs, M., Vetesi, F., Kovacs, F., Bata, A, Toth, A., Tomyas, G. (2000). Preliminary communication: Examination of the harmful effect to fetuses of fumonisin B1 in pregnant sows. Teratogenesis Cetitıogetıesis Mutagenesis, 20,293-299.