Understanding How Madecassic Acid Affects Glioblastoma Cells: Its Antioxidant and Anti-cancer Properties

Abstract

Glioblastoma, a malignant brain tumor, poses significant therapeutic challenges due to its aggressive nature and limited treatment options. The search for novel compounds with potential therapeutic efficacy against this devastating disease remains imperative. Madecassic acid (MA), a triterpenoid derived from Centella asiatica, has emerged as a promising candidate with multifaceted pharmacological activities, including antioxidant and antitumor effects. However, its specific impact on glioblastoma cells necessitates further exploration to fully comprehend its therapeutic potential. In this investigation, we examined the effects of MA on a human glioblastoma cell line, with a primary focus on its antioxidant and anti-proliferative properties. Utilizing a comprehensive range of cellular and molecular assays, we unraveled the potential of MA in scavenging free radicals, mitigating oxidative stress, and inhibiting glioblastoma cell proliferation. The study revealed that MA significantly inhibited glioblastoma cell growth. Furthermore, MA-treated cells exhibited higher antioxidant enzyme activity and lower oxidative stress levels compared to untreated cells. These findings demonstrate the potential of MA as an effective therapeutic agent against glioblastoma. By elucidating its antioxidant and anti-proliferative effects, this research opens new avenues for innovative treatment strategies to combat this relentless brain tumor. The insights gained from this study may contribute to improved patient outcomes and revolutionize the landscape of glioblastoma therapy.

Keywords

• cell viability
• glioblastoma cell line
• GBM
• madecassic acid
• oxidative stress.

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