Intervertebral disc degeneration, inflammation, and bioactive lipids

Year 2024, Volume: 2 Issue: 3, 115 - 122, 30.12.2024

Undurti Das , Ahmet Hacımüftüoğlu

https://doi.org/10.62425/rtpharma.1589019

Abstract

Intervertebral disc degeneration, inflammation, and bioactive lipids
Intervertebral disc degeneration
Intervertebral disc (IVD) degeneration is a common condition that is associated with significant morbidity. There is no specific treatment available for IVD except for surgical intervention. IVD is an inflammatory condition. I propose that IVD can be prevented and managed by local administration of lipoxin A4 (LXA4), a potent anti-inflammatory, cytoprotective and anti-osteoporotic metabolite formed from arachidonic acid (AA).
Keywords: intervertebral disc, degeneration, lipoxin A4, arachidonic acid, inflammation.

Keywords

intervertebral disc , degeneration , lipoxin A4 , arachidonic acid , inflammation

References

• Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CN. Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano Proresolving Medicines. Journal of Immunology. 2014; 193: 4235–4244.
• Bridgen DT, Fearing BV, Jing L, Sanchez-Adams J, Cohan MC, Guilak F, Chen J, Setton LA. Regulation of human nucleus pulposus cells by peptide-coupled substrates. Acta Biomaterialia. 2017; 55: 100-108.
• Das UN. "Cell Membrane Theory of Senescence" and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Biomolecules. 2021; 11(2): 241. Implications.
• Das UN. Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review. J Adv Res. 2018; 11: 67-79.
• Das UN. Bioactive Lipids as Mediators of the Beneficial Action(s) of Mesenchymal Stem Cells in COVID-19. Aging and disease. 2020; 11(4): 746-755.
• Das UN. Bioactive lipids in intervertebral disc degeneration and its therapeutic implications. Biosci Rep. 2019 Oct 30;39(10):BSR20192117. doi: 10.1042/BSR20192117.
• Gundala NKV, Naidu VGM, Das UN. Arachidonic acid and lipoxin A4 attenuate alloxan-induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo. Biofactors. 2017; 43(2): 251-271.
• Gundala NKV, Naidu VGM, Das UN. Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo. Nutrition. 2017; 35: 61-80.
• Li J, Guan H, Liu H, Zhao L, Li L, Zhang Y, Tan P, Mi B, Li F. Epoxyeicosanoids prevent intervertebral disc degeneration in vitro and in vivo. Oncotarget 2017; 8: 3781–3797.
• Lomakin AJ, Cattin CJ, Cuvelier D, Alraies Z, Molina M, Nader GPF, Srivastava N, Sáez PJ, Garcia-Arcos JM, Zhitnyak IY, Bhargava A, Driscoll MK, Welf ES, Fiolka R, Petrie RJ, De Silva NS, González-Granado JM, Manel N, Lennon Duménil AM, Müller DJ, Piel M. The nucleus acts as a ruler tailoring cell responses to spatial constraints. Science. 2020 Oct 16;370(6514):eaba2894. doi: 10.1126/science.aba2894. PMID: 33060332; PMCID: PMC8059074.
• Martino F, Perestrelo AR, Vinarský V, Pagliari S, Forte G. Cellular Mechanotransduction: From Tension to Function. Frontiers in Physiology. 2018 Jul 5;9:824. doi: 10.3389/fphys.2018.00824. PMID: 30026699; PMCID: PMC6041413.
• Miao GS, Liu ZH, Wei SX, Luo JG, Fu Z.J, Sun T. Lipoxin A4 attenuates radicular pain possibly by inhibiting spinal ERK, JNK and NF-κB/p65 and cytokine signals, but not p38, in a rat model of non-compressive lumbar disc herniation. Neuroscience 2015; 300, 0-18.
• Milazzo S, Horneber M. Laetrile treatment for cancer. Cochrane Database of Systematic Reviews. 2015 Apr 28;2015(4):CD005476. doi: 10.1002/14651858.CD005476.pub4. PMID: 25918920; PMCID: PMC6513327.
• Prager J, Deer T, Levy R, Bruel B, Buchser E, Caraway D, Cousins M, Jacobs M, McGlothlen G, Rauck R, Staats P, Stearns L. Best practices for intrathecal drug delivery for pain. Neuromodulation. 2014; 17(4): 354-372.
• Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, Alini M, Risbud MV, Chan D, Cheah KS, Yamamura K, Masuda K, Okano H, Ando K, Mochida J. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nature Communications. 2012; 3: 1264.
• Shen Z, Niethammer P. A cellular sense of space and pressure. Science. 2020 Oct 16;370(6514):295-296. doi: 10.1126/science.abe3881. PMID: 33060351.
• Simpson KH, Jones I. Intrathecal drug delivery for management of cancer and noncancer pain. Journal of Opioid Management. 2008; 4(5): 293-304.
• Tateishi N, Kaneda Y, Kakutani S, Kawashima H, Shibata H, Morita I. Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or rostaglandin E2 content in rat adjuvant-induced arthritis model. Lipids in Health and Disease. 2015; 14: 3.
• Tateishi, N., Kakutani, S., Kawashima, H, Shibata H, Morita I. Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin A4 contents in colon, but does not affect severity or prostaglandin E2 content in murine colitis model. Lipids in Health and Disease. 2014; Recent Trends in Pharmacology 122 13: 30.
• Venturini V, Pezzano F, Català Castro F, Häkkinen HM, Jiménez-Delgado S, Colomer-Rosell M, Marro M, Tolosa Ramon Q, Paz-López S, Valverde MA, Weghuber J, LozaAlvarez P, Krieg M, Wieser S, Ruprecht V. The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior. Science. 2020 Oct 16;370(6514):eaba2644. doi: 10.1126/science.aba2644. PMID: 33060331.
• Wang C, Yu X, Yan Y, Yang W, Zhang S, Xiang Y, Zhang J, Wang W. Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration. Acta Biochimica et Biophysica Sinica(Shanghai). 2017 Jan;49(1):1-3.
• Zeng Q, Sun Q, Xu H, Chen J, Ling H, Ge Q, Zou K, Wang X, Jin H, Li J, Jin M. Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response. Journal of Inflammation Research. 2023:16 3455–3468.