Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications

Murat Kösedağ

doi:10.62425/rtpharma.1770239

Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications

Abstract

Orlistat is a widely used gastrointestinal lipase inhibitor for obesity management. While its efficacy and safety are established under medical supervision, increasing unsupervised use has raised concerns regarding serious adverse events. This review aims to alert healthcare providers to the potential for significant adverse effects associated with Orlistat by synthesizing a collection of reported clinical cases. The review includes literature published between January 1988 and March 2025. We present case reports highlighting a range of adverse effects, including acute pancreatitis, hepatotoxicity, and acute oxalate nephropathy. These conditions are often linked to patient-specific vulnerabilities, pre-existing health conditions, or misuse, particularly among individuals with eating disorders. This review underscores the importance of careful patient selection, close monitoring, and increased awareness among family physicians, pharmacists, and other healthcare providers to ensure the safe use of Orlistat. When appropriately prescribed and monitored, Orlistat remains a valuable tool in obesity management. However, its unsupervised use and potential for abuse can lead to significant health risks, emphasizing the need for professional oversight.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences, Clinical Pharmacology and Therapeutics, Medical Pharmacology

Journal Section

Review Article

Authors

Murat Kösedağ ^*
0000-0003-0141-4689
Türkiye

Publication Date

January 15, 2026

Submission Date

August 22, 2025

Acceptance Date

September 6, 2025

Published in Issue

Year 2025 Volume: 3 Number: 3

DOI

https://doi.org/10.62425/rtpharma.1770239

IZ

https://izlik.org/JA43XJ59EK

Cite

RIS / Bibtex

APA

Kösedağ, M. (2026). Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications. Recent Trends in Pharmacology, 3(3), 110-120. https://doi.org/10.62425/rtpharma.1770239

AMA

1.Kösedağ M. Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications. Recent Trends in Pharmacology. 2026;3(3):110-120. doi:10.62425/rtpharma.1770239

Chicago

Kösedağ, Murat. 2026. “Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications”. Recent Trends in Pharmacology 3 (3): 110-20. https://doi.org/10.62425/rtpharma.1770239.

EndNote

Kösedağ M (January 1, 2026) Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications. Recent Trends in Pharmacology 3 3 110–120.

IEEE

[1]M. Kösedağ, “Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications”, Recent Trends in Pharmacology, vol. 3, no. 3, pp. 110–120, Jan. 2026, doi: 10.62425/rtpharma.1770239.

ISNAD

Kösedağ, Murat. “Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications”. Recent Trends in Pharmacology 3/3 (January 1, 2026): 110-120. https://doi.org/10.62425/rtpharma.1770239.

JAMA

1.Kösedağ M. Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications. Recent Trends in Pharmacology. 2026;3:110–120.

MLA

Kösedağ, Murat. “Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications”. Recent Trends in Pharmacology, vol. 3, no. 3, Jan. 2026, pp. 110-2, doi:10.62425/rtpharma.1770239.

Vancouver

1.Murat Kösedağ. Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications. Recent Trends in Pharmacology. 2026 Jan. 1;3(3):110-2. doi:10.62425/rtpharma.1770239