Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions

Rofanda Bakeer; Omar Ahmed-Farid; Amira N. Abd-El Razik

doi:10.62425/rtpharma.1947838

Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions

Abstract

Objective: Intelectin-1 (ITLN1) is an adipokine involved in metabolic and immune regulation, yet its spatial expression and potential contribution to colorectal tumor progression and microenvironmental remodeling remain incompletely understood. This study investigated the expression and spatial distribution of ITLN1 across distinct colorectal pathological conditions. Methods: A total of 60 patients were categorized into four groups: hyperplastic polyps, conventional adenomas, inflammatory bowel disease, and colorectal carcinoma. ITLN1 expression was evaluated using immunohistochemistry (IHC) combined with digital image analysis to quantitatively assess its localization within epithelial and stromal compartments. Histopathological examination using routine hematoxylin and eosin (H&E) staining provided a structural context for correlating ITLN1 expression with architectural features and degrees of dysplasia. Results: The results demonstrated a progressive reduction in ITLN1 immunoreactivity across the studied pathological conditions, with the lowest staining intensity, positive area, H-score, and relative integrated optical density observed in colorectal adenocarcinoma. In parallel, the epithelial predominance of ITLN1 expression was progressively reduced, with G4 adenocarcinoma showing a marked loss of epithelial ITLN1 expression and the highest proportion of ITLN1-negative glands. Conclusion: These findings indicate that colorectal adenocarcinoma is characterized primarily by an overall loss of ITLN1 expression accompanied by loss of its epithelial predominance, rather than an absolute increase in stromal ITLN1.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Rofanda Bakeer
0000-0001-8202-2999
Egypt

Omar Ahmed-Farid ^*
0000-0002-1020-5777
Egypt

Amira N. Abd-El Razik This is me
0000-0001-8202-2881
Egypt

Early Pub Date

August 12, 2026

Publication Date

-

Submission Date

May 14, 2026

Acceptance Date

July 22, 2026

Published in Issue

Year 2026 Number: Advanced Online Publication

DOI

https://doi.org/10.62425/rtpharma.1947838

IZ

https://izlik.org/JA58UC74ME

Cite

RIS / Bibtex

APA

Bakeer, R., Ahmed-Farid, O., & N. Abd-El Razik, A. (2026). Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions. Recent Trends in Pharmacology, Advanced Online Publication. https://doi.org/10.62425/rtpharma.1947838

AMA

1.Bakeer R, Ahmed-Farid O, N. Abd-El Razik A. Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions. Recent Trends in Pharmacology. 2026;(Advanced Online Publication). doi:10.62425/rtpharma.1947838

Chicago

Bakeer, Rofanda, Omar Ahmed-Farid, and Amira N. Abd-El Razik. 2026. “Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions”. Recent Trends in Pharmacology, no. Advanced Online Publication. https://doi.org/10.62425/rtpharma.1947838.

EndNote

Bakeer R, Ahmed-Farid O, N. Abd-El Razik A (August 1, 2026) Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions. Recent Trends in Pharmacology Advanced Online Publication

IEEE

[1]R. Bakeer, O. Ahmed-Farid, and A. N. Abd-El Razik, “Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions”, Recent Trends in Pharmacology, no. Advanced Online Publication, Aug. 2026, doi: 10.62425/rtpharma.1947838.

ISNAD

Bakeer, Rofanda - Ahmed-Farid, Omar - N. Abd-El Razik, Amira. “Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions”. Recent Trends in Pharmacology. Advanced Online Publication (August 1, 2026). https://doi.org/10.62425/rtpharma.1947838.

JAMA

1.Bakeer R, Ahmed-Farid O, N. Abd-El Razik A. Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions. Recent Trends in Pharmacology. 2026. doi:10.62425/rtpharma.1947838.

MLA

Bakeer, Rofanda, et al. “Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions”. Recent Trends in Pharmacology, no. Advanced Online Publication, Aug. 2026, doi:10.62425/rtpharma.1947838.

Vancouver

1.Rofanda Bakeer, Omar Ahmed-Farid, Amira N. Abd-El Razik. Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions. Recent Trends in Pharmacology. 2026 Aug. 1;(Advanced Online Publication). doi:10.62425/rtpharma.1947838