Proton channels in the context of human diseases

Year 2025, Volume: 3 Issue: 3, 1 - 7

Mustafa Erdem Sağsöz

https://doi.org/10.62425/rtpharma.1771654

Abstract

Proton channels in the context of human diseases

ABSTRACT
Proton channels play an important role in many physiological processes in humans, as in all organisms, since pH determines protonation or deprotonisation state of amino acid residues, thus channel activity, enzyme kinetics, receptor-ligand interactions by changing the surface charges of molecules. These integral protein structures, which selectively transport protons through biological membranes, are very important for cell homeostasis, energy production and signal transmission. Human diseases associated with proton channels can be easily studied in genetic model organisms, since their basic structure and function have been preserved between species. Proton channels in humans, are an important part of many vital processes, including the regulation of pH in cellular compartments, the generation of bioelectric signals in neurons, and the immune response. Studies about proton channels conducted to date, including deviations in proton channel function have been associated with a variety of diseases, from neurodegenerative disorders to cardiovascular diseases and cancer. Valuable information about their special contributions to human physiology and pathophysiology can be obtained by deciphering their different roles in these structures. The aim of this review is to summarize the effects of proton channels on organisms through their functions, especially on human diseases, to provide a comprehensive overview of their biological importance and potential as therapeutic targets.

Keywords: Otopetrin, pH, proton channels, voltage-gated.

Keywords

Otopetrin , pH , proton channels , voltage-gated

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