YENİ BOR ESTER TÜREVLERİNİN YARA İYİLEŞMESİ ÜZERİNDEKİ ETKİSİ

Abstract

Bor fiziksel ve kimyasal özellikleri ile yeni biyolojik özelliklere sahip bor içeren moleküller oluşturmayı olanaklı kılar ve moleküler tasarım ile tıbbi uygulamalar yeni alanlarının araştırılması sonucunda insanlığa ve bilim insanlarına fırsatlar sunar. Bu çalışmada; bir pilot çalışma ile etkinliği göreceli test edilmiş bor içerikli 2 adet sentez molekülün yara iyileşmesine etkisini daha geniş örneklem ile test etmek için faz 0, in vivo, in vitro çalışmalarını gerçekleştirerek yeni ürün geliştirmek amaçlandı. Yara iyileşme açısından molekül 1'in yara iyileşme yüzdesi diğer tüm gruplardan daha yüksekti (p = 0.001) ve kronik bir cilt altı enflamatuvar reaksiyona yol açmadı (p<0.05). Kolajen üretimi açısından molekül 1’in 7. günde (p<0.05) ve molekül 2'nin 14. günde (p<0.05) kolajen üretimi daha yüksekti. Bor içerikli sentez içerikli molekülleri, yara iyileşmesini makroskopik (yara iyileşme yüzdesi) ve mikroskopik (mikrobiyolojik, histopatolojik ve immünohistokimyasal) olarak desteklemektedir. Çalışma sonucunda 2 adet patent başvurusu yapılmıştır.

Keywords

• Yara iyileşmesi
• yara bakımı
• bor

The Effect of Novel Boron Ester Derivatives on Wound Healing

Abstract

Boron's unique physical and chemical characteristics make it possible to create novel boron-containing molecules resulting in a wide range of distinct biological properties. This paves the way for exciting prospects in various scientific disciplines and medical applications through advanced molecular design and research. In this study, two novel boron-containing molecules were synthesized and their effect on wound healing property were tested in a pilot study as phase 0, in vivo and in vitro in order to test them on a larger sample. The wound healing percentage of molecule 1 was higher than that of all other groups in terms of wound healing percentage (p = 0.001), and it did not lead to a chronic subcutaneous inflammatory reaction (p<0.05). Collagen production of molecule 1 and molecule 2 on day 7 (p<0.05) and that of molecule 2 on day 14 (p>0.05) were higher. In this study, obtained boron containing compounds show promising effect on wound healing macroscopically (wound healing percentage) and microscopically (microbiological, histopathological, and immunohistochemical). As a result of the study, 2 patent applications were made.

Keywords

• Wound healing
• wound care
• boron

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