Topical Oxygen Applications in Wound Care

Abstract

In recent years, there is a need for innovative approaches in wound healing. Since oxygen accelerates wound healing, the use of methods that facilitate oxygen diffusion to the wound bed is increasing. There are many different methods of topical oxygen applications such as intermittent-continuous, high-pressure-low-pressure, portable-fixed. This review article was prepared to examine the indications, contraindications, types and application methods of topical oxygen applications used in chronic wound care in recent years.

Keywords

• topical oxygen
• hyperbaric oxygen
• topical haemoglobin
• wound treatment

Yarada Topikal Oksijen Uygulamaları

Abstract

Günümüzde yara iyileşmesinde yenilikçi yaklaşımlara ihtiyaç duyulmaya başlanmıştır. Oksijenin yara iyileşmesini hızlandırması nedeniyle, yara yatağına oksijen difüzyonunu kolaylaştıran yöntemlerin kullanımı giderek artmaktadır. Topikal oksijen uygulamalarının aralıklı-sürekli, yüksek basınçlı- düşük basınçlı, portatif-sabit olmak üzere birçok farklı metotları bulunmaktadır. Bu derleme makalesinde kronik yara bakımında son yıllarda kullanılan topikal oksijen uygulamalarının endikasyonları, kontrendikasyonları, türleri ve uygulama şekillerini incelemek amacıyla hazırlanmıştır.

Keywords

• topikal oksijen
• hiperbarik oksijen
• topikal hemoglobin
• yara tedavisi

References

1. Aoki, K., Ida, Y., Fukushima, N., & Matsumura, H. (2022). Topical application of oxygen nano-bubble water enhances the healing process of ischaemic skin wound healing in an animal model. International Wound Journal, 19(7), 1843–1852. https://doi.org/10.1111/IWJ.13790
2. Blackman, E., Moore, C., Hyatt, J., Railton, R., & Frye, C. (2010). Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: A prospective controlled study. Ostomy Wound Management, 56(6).
3. Carter, M. J., Frykberg, R. G., Oropallo, A., Sen, C. K., Armstrong, D. G., Nair, H. K. R., & Serena, T. E. (2023). Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: Systematic review and meta-analysis. Advances in Wound Care, 12(4), 177–186. https://doi.org/10.1089/wound.2022.0041
4. Choi, J., Hong, G., Kwon, T., & Lim, J. O. (2018). Fabrication of oxygen releasing scaffold by embedding H2O2-PLGA microspheres into alginate-based hydrogel sponge and its application for wound healing. Applied Sciences, 8(1492), 1–14. https://doi.org/10.3390/app8091492
5. Davies, P. (2020). Granulox ® (Topical haemoglobin spray): A review of the scientific and clinical data. www.molnlycke.com
6. Dissemond, J., Kröger, K., Storck, M., Risse, A., & Engels, P. (2015). Topical oxygen wound therapies for chronic wounds: A review. Journal of Wound Care, 24(2), 53–63.
7. Fries, R. B., Wallace, W. A., Roy, S., Kuppusamy, P., Bergdall, V., Gordillo, G. M., Melvin, W. S., & Sen, C. K. (2005). Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 579(1–2). https://doi.org/10.1016/j.mrfmmm.2005.02.023
8. Frykberg, R. G. (2021). Topical wound oxygen therapy in the treatment of chronic diabetic foot ulcers. Medicina, 57(917), 1–9. https://doi.org/10.3390/medicina57090917

9. Gonçalvez, V., & Schofield, A. (2024). Continuous topical oxygen therapy. Wounds International, 1–6.
10. Gottrup, F., Dissemond, J., Baines, C., Frykberg, R., Jensen, P., Kot, J., Kröger, K., & Longobardi, P. (2017). Use of oxygen therapies in wound healing. Journal of Wound Care, 26(5), 514–522.
11. Han, X., Ju, L. S., & Irudayaraj, J. (2023). Oxygenated Wound Dressings for Hypoxia Mitigation and Enhanced Wound Healing. Molecular Pharmaceutics, 20(7), 3338–3355. https://doi.org/10.1021/acs.molpharmaceut.3c00352
12. Hinchliffe, R. J., Forsythe, R. O., Apelqvist, J., Boyko, E. J., Fitridge, R., Hong, J. P., Katsanos, K., Mills, J. L., Nikol, S., Reekers, J., Venermo, M., Zierler, R. E., & Schaper, N. C. (2020). Guidelines on diagnosis, prognosis, and management of peripheral artery disease in patients with foot ulcers and diabetes (IWGDF 2019 update). Diabetes/Metabolism Research and Reviews, 36(S1). https://doi.org/10.1002/dmrr.3276
13. Howard, M. A., Asmis, R., Evans, K. K., & Mustoe, T. A. (2013). Oxygen and wound care: A review of current therapeutic modalities and future direction. Wound Repair and Regeneration, 21(4), 503–511. https://doi.org/10.1111/wrr.12069
14. Hunt, S. D., & Elg, F. (2016). Clinical effectiveness of hemoglobin spray (Granulox ® ) as adjunctive therapy in the treatment of chronic diabetic foot ulcers. Diabetic Foot & Ankle, 7(1), 33101. https://doi.org/10.3402/dfa.v7.33101
15. Hunt, S., & Elg, F. (2017). The clinical effectiveness of haemoglobin spray as adjunctive therapy in the treatment of chronic wounds. Journal of Wound Care, 26(9), 558–568. https://doi.org/10.12968/jowc.2017.26.9.558
16. Ivins, N., Simmonds, W., Turner, A., & Harding, K. (2007). The use of an oxygenating hydrogel dressing in VLU. Wounds UK, 3(1), 1–5.
17. Jonker, L., Smith, D., Mark, E., Thornthwaite, S., Gunn, C., & Fisher, S. (2021). A pragmatic, single-center, prospective, randomized controlled trial of adjunct hemoglobin-mediated granulox topical oxygen therapy twice weekly for foot ulcers. Journal of the American Podiatric Medical Association, 111(5). https://doi.org/10.7547/19-189
18. Kalliainen, L. K., Gordillo, G. M., Schlanger, R., & Sen, C. K. (2003). Topical oxygen as an adjunct to wound healing: a clinical case series. Pathophysiology, 9(2), 81–87. https://doi.org/10.1016/S0928-4680(02)00079-2
19. Lam, G., Fontaine, R., Ross, F. L., & Chiu, E. S. (2017). Hyperbaric oxygen therapy: Exploring the clinical evidence. Advances in Skin and Wound Care, 30(4), 181–190. https://doi.org/10.1097/01.ASW.0000513089.75457.22
20. Lavery, L. A., Niederauer, M. Q., Papas, K. K., & Armstrong, D. G. (2019). Does debridement improve clinical outcomes in people with diabetic foot ulcers treated with continuous diffusion of oxygen? Wounds, 31(10), 246–251.
21. Nagarsheth, K., Kankaria, A., Marsella, J., Dunlap, E., Hawkins, S., Ucuzian, A., & Lal, B. K. (2024). Systematic review of the effects of topical oxygen therapy on wound healing. JVS-Vascular Insights, 2, 100051. https://doi.org/10.1016/J.JVSVI.2023.100051
22. Njokweni, M. (2023). Adjunctive topical oxygen therapy in the management of complex diabetes-related wounds: A South African case study series. Foot, 57(101961). https://doi.org/10.1016/j.foot.2023.101961
23. Norris, R. (2014). A topical haemoglobin spray for oxygenating chronic venous leg ulcers: a pilot study. British Journal of Nursing, 23(Sup20), S48–S53. https://doi.org/10.12968/bjon.2014.23.Sup20.S48
24. Oropallo, A., & Andersen, C. A. (2023). Topical Oxygen. In Treasure Island (FL): StatPearls Publishing.
25. Oropallo, A. R., Serena, T. E., Armstrong, D. G., & Niederauer, M. Q. (2021). Molecular biomarkers of oxygen therapy in patients with diabetic foot ulcers. Biomolecules, 11(7), 925. https://doi.org/10.3390/biom11070925
26. Ozan, F., Altay, T., & Kayalı, C. (2017). Hiperbarik oksijen tedavisi. TOTBID Dergisi, 16(3), 187–195. https://doi.org/10.14292/totbid.dergisi.2017.28
27. Pasek, J., Szajkowski, S., & Cieślar, G. (2023). Application of topical hyperbaric oxygen therapy and medical active dressings in the treatment of arterial leg ulcers-A pilot study. Sensors (Basel, Switzerland), 23(12), 5582. https://doi.org/10.3390/S23125582
28. Sun, X., Li, R., Yang, X., & Yuan, L. (2022). Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta‐analysis. International Wound Journal, 19(8), 2200–2209. https://doi.org/10.1111/iwj.13830
29. Tawfick, W. A., & Sultan, S. (2013). Technical and clinical outcome of topical wound oxygen in comparison to conventional compression dressings in the management of refractory nonhealing venous ulcers. Vascular and Endovascular Surgery, 47(1), 30–37. https://doi.org/10.1177/1538574412467684
30. Tickle, J. (2015a). A topical haemoglobin spray for oxygenating pressure ulcers: A pilot study. British Journal of Community Nursing, 20(3). https://doi.org/10.12968/bjcn.2015.20.Sup3.S12
31. Tickle, J. (2015b). Use of a topical haemoglobin spray for oxygenating pressure ulcers: Healing outcomes. British Journal of Community Nursing, 20. https://doi.org/10.12968/bjcn.2015.20.Sup12.S14
32. Uçar, Ö., & Özcan İlçe, A. (2024). Basınç Yarası Bakımında Topikal Hemoglobin Etkilerinin İncelenmesi [PhD thesis]. Bolu Abant Izzet Baysal Üniversitesi .
33. Xie, X., Xu, R., Zhang, J., Tao, J., Bian, X., & Hou, J. (2023). The effect of topical oxygen therapy on the intervention of patients with diabetic foot ulcers：a Meta-analysis. Chinese Journal of Nursing, 58(24), 2976–2983. https://doi.org/10.3761/j.issn.0254-1769.2023.24.005
34. Yu, J., Lu, S., McLaren, A. M., Perry, J. A., & Cross, K. M. (2016). Topical oxygen therapy results in complete wound healing in diabetic foot ulcers. Wound Repair and Regeneration, 24(6), 1066–1072. https://doi.org/10.1111/wrr.12490