Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi

Year 2019, , 115 - 125, 30.12.2019

Hilal Şentürk Evrim Komurcu-bayrak

https://doi.org/10.26650/JARHS2019-638138

Abstract

Kardiyovasküler hastalıklar (KVH'lar), mortalite ve morbiditenin en önemli nedeni olup çoğunlukla yetişkinlerde gözlenmektedir. KVH’ların altında yatan ana mekanizma, fibröz plakların oluşumu, düz kas hücrelerinin çoğalması ve enflamatuvar hücrelerin göçü ile meydana gelen karmaşık bir patoloji olan aterosklerozdur. Son çalışmalar, uzun kodlamayan RNA'lar (lncRNA) ve dairesel RNA'lar (circRNA) gibi protein kodlamayan RNA'ların, ateroskleroz dahil tüm KVH’ların epigenetiğinde önemli düzenleyici rollere sahip olduğunu göstermektedir. Bu derlemede, lncRNA'ların ve circRNA'ların fonksiyonel aktiviteleri ve bunların ateroskleroz ve KVH’larla olan ilişkileri özetlenmektedir.

Keywords

Kardiyovasküler hastalıklar, uzun kodlamayan RNA, sirküler RNA

Supporting Institution

İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi

Project Number

TYL-2017-27636

The Importance of Long Noncoding RNAs in Cardiovascular Diseases

Abstract

Cardiovascular diseases (CVDs) are a leading cause of mortality and morbidity and mostly affect adults. The main underlying mechanism of CVDs is atherosclerosis and this complex pathology is caused by the formation of fibrous plaques, the proliferation of smooth muscle cells and the migration of inflammatory cells. Recent studies suggest that noncoding RNAs such as long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) have critical regulatory roles in the epigenetics of all CVDs including atherosclerosis. This review summarizes the functional roles of lncRNAs and circRNAs and their relationships with atherosclerosis and CVDs. 

Keywords

Cardiovascular diseases, long noncoding RNA, circular RNA

Project Number

TYL-2017-27636

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