EN
LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection
Abstract
Early and accurate diagnosis, however, is still lacking for the most common form of lung cancer, and this remains one of the leading cancers leading to mortality. CT scans are widely used for lung cancer screening; however, their manual interpretation is time-consuming and prone to variability. This study introduces LungDxNet, a deep learning-based framework that integrates transfer learning to enhance diagnostic accuracy and efficiency. Using a large dataset of Low Dose CT (LDCT) scans, the system is built with fine-tuned pre-trained Convolutional Neural Networks (CNNs) such that feature extraction is reliable though minimal reducing radiation exposure. Consequently, LungDxNet involves the integration of component segmentation techniques that have been used to isolate the lung regions and discriminate the cancerous nodules from the malignant and benign cases. Very rigorous evaluations were performed on the model against both conventional machine learning and state of the art deep learning architectures. Results show that there is a substantial reduction of false positive and false negative resulting in a superior accuracy (98.88), sensitivity, and specificity. This design is to be scaled, robust and clinically applicable, making it a potential real world lung cancer diagnosis tool. Deep learning and transfer learning has excellent power to transform lung cancer detection, and this research brings awareness of how far we can optimise and integrate into clinical workflow. The model is enhanced for future work and adapted for real time diagnostic applications.
Keywords
References
- B. Ozdemir, E. Aslan, and I. Pacal, "Attention enhanced inceptionNext-based hybrid deep learning model for lung cancer detection," IEEE Access, vol. 13, pp. 27050–27069, 2025, doi: 10.1109/ACCESS.2025.3539122.
- H. Rajaguru and K. Shanmugam, "Enhanced superpixel guided ResNet framework with optimized deep weighted averaging based feature fusion for lung cancer detection in histopathological images," Preprints, Feb. 2025, doi: 10.20944/preprints202502.0736.v1.
- M. Reck, S. Dettmer, H.-U. Kauczor, R. Kaaks, N. Reinmuth, and J. Vogel-Claussen, "Lung cancer screening with low-dose computed tomography: Current status in Germany," Dtsch. Arztebl. Int., Jun. 2023, doi: 10.3238/arztebl.m2023.0099.
- A. Schreuder, E. T. Scholten, B. van Ginneken, and C. Jacobs, "Artificial intelligence for detection and characterisation of pulmonary nodules in lung cancer CT screening: Ready for practice?," Transl. Lung Cancer Res., vol. 10, no. 5, pp. 2378–2388, May 2021, doi: 10.21037/tlcr-2020-lcs-06.
- A. K. Esim, H. Kaya, and V. Alcan, "Determination of malignant melanoma by analysis of variation values," Turkish J. Eng., vol. 3, no. 3, pp. 120–126, Jul. 2019, doi: 10.31127/tuje.472328.
- M. Dirik, "Machine learning-based lung cancer diagnosis," Turkish J. Eng., vol. 7, no. 4, pp. 322–330, Oct. 2023, doi: 10.31127/tuje.1180931.
- S. N. Polater and O. Sevli, "Deep learning based classification for alzheimer's disease detection using MRI images," Turkish J. Eng., vol. 8, no. 4, pp. 729–740, Oct. 2024, doi: 10.31127/tuje.1434866.
- D. Maza, J. O. Ojo, and G. O. Akinlade, "A predictive machine learning framework for diabetes," Turkish J. Eng., vol. 8, no. 3, pp. 583–592, Jul. 2024, doi: 10.31127/tuje.1434305.
Details
Primary Language
English
Subjects
Computer Software
Journal Section
Research Article
Authors
Early Pub Date
June 13, 2025
Publication Date
June 30, 2025
Submission Date
March 25, 2025
Acceptance Date
April 21, 2025
Published in Issue
Year 2025 Volume: 8 Number: 2
APA
Sahu, P., Kumar, A., Singh, M. K., Jain, R., Upreti, K., & Parashar, J. (2025). LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection. Sakarya University Journal of Computer and Information Sciences, 8(2), 184-197. https://doi.org/10.35377/saucis...1665478
AMA
1.Sahu P, Kumar A, Singh MK, Jain R, Upreti K, Parashar J. LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection. SAUCIS. 2025;8(2):184-197. doi:10.35377/saucis.1665478
Chicago
Sahu, Premananda, Ashwani Kumar, Mahesh K. Singh, Rituraj Jain, Kamal Upreti, and Jyoti Parashar. 2025. “LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection”. Sakarya University Journal of Computer and Information Sciences 8 (2): 184-97. https://doi.org/10.35377/saucis. 1665478.
EndNote
Sahu P, Kumar A, Singh MK, Jain R, Upreti K, Parashar J (June 1, 2025) LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection. Sakarya University Journal of Computer and Information Sciences 8 2 184–197.
IEEE
[1]P. Sahu, A. Kumar, M. K. Singh, R. Jain, K. Upreti, and J. Parashar, “LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection”, SAUCIS, vol. 8, no. 2, pp. 184–197, June 2025, doi: 10.35377/saucis...1665478.
ISNAD
Sahu, Premananda - Kumar, Ashwani - Singh, Mahesh K. - Jain, Rituraj - Upreti, Kamal - Parashar, Jyoti. “LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection”. Sakarya University Journal of Computer and Information Sciences 8/2 (June 1, 2025): 184-197. https://doi.org/10.35377/saucis. 1665478.
JAMA
1.Sahu P, Kumar A, Singh MK, Jain R, Upreti K, Parashar J. LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection. SAUCIS. 2025;8:184–197.
MLA
Sahu, Premananda, et al. “LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection”. Sakarya University Journal of Computer and Information Sciences, vol. 8, no. 2, June 2025, pp. 184-97, doi:10.35377/saucis. 1665478.
Vancouver
1.Premananda Sahu, Ashwani Kumar, Mahesh K. Singh, Rituraj Jain, Kamal Upreti, Jyoti Parashar. LungDxNet: AI-Powered Low-Dose CT Analysis for Early Lung Cancer Detection. SAUCIS. 2025 Jun. 1;8(2):184-97. doi:10.35377/saucis. 1665478
