İleri Glikasyon Son Ürünlerinin Gebelik Üzerine Etkisi

Year 2022, , 39 - 55, 15.04.2022

Özlem Akın , Yağmur Demirel Özbek

https://doi.org/10.54803/sauhsd.1000948

Abstract

İleri glikasyon son ürünleri, çok çeşitli yapısal ve fonksiyonel özelliklere sahip, herhangi bir canlı organizmada oluşan ve enzimatik olmayan bileşiklerdir. İleri glikasyon son ürünleri reseptöre veya doğrudan hücre dışı matrikse bağlanır ve hücre dışı moleküllerin istenilen şekilde çalışmamasına yol açar. İleri glikasyon son ürünleri ve reseptör etkileşimleri inflamasyon, oksidatif stres, vasküler hiperpermeabilite ile sonuçlanarak vaskülatürde homeostatik bozulmaya neden olur. Oksidatif bozukluklar ve inflamasyon; gestasyonel diyabet, preeklemsi, erken doğum, erken membran rüptürü ve tekrarlayan gebelik kaybı gibi olumsuz gebelik sonuçları ile ilişkilidir. Literatüre bakıldığında inflamasyon fetal membranları zayıflatarak erken rüptüre ve erken doğuma sebep olabilmektedir. İleri glikasyon son ürünleri düzeyinin yüksek olması ve bozulmuş metabolik durumun gebelikte preeklemsinin fizyopatolojisine etki ettiği gestasyonel diabetes mellitus ve tekrarlayan gebelik kayıpları ile ilişkilendirildiği belirtilmektedir. Çalışmalar, gebelik ve AGE’lerin düzeyi arasında güçlü bir ilişki olduğunu göstermektedir. AGE’ler ve gebelik arasındaki nedensel ilişkiyi bulmak için daha iyi tasarlanmış çalışmalar yapılması literatür açısından önem taşımaktadır.

Keywords

Gebelik, gestasyonel diyabetes mellitus, ileri glikasyon son ürünleri, oksidatif stres, preeklemsi

The Effect of Advanced Glycation End Products on Pregnancy

Abstract

Advanced glycation end products are non-enzymatic compounds which have a wide variety of structural and functional properties and which occur in any living organism. Advanced glycation end products bind to the receptor or directly to the extracellular matrix and cause the extracellular molecules to malfunction. Advanced glycation end products and receptor interactions result in inflammation, oxidative stress, and vascular hyper permeability, causing homeostatic deterioration in the vasculature. Oxidative disorders and inflammation; gestational diabetes is associated with adverse pregnancy outcomes such as preeclampsia, preterm birth, premature rupture of membranes, and recurrent pregnancy loss. Looking at the literature, inflammation may weaken fetal membranes and cause premature rupture and preterm delivery. It is stated that high levels of advanced glycation end products and impaired metabolic status affect the physiopathology of preeclampsia during pregnancy and are associated with gestational diabetes mellitus and recurrent pregnancy losses. Studies show a strong correlation between pregnancy and the level of AGEs. It is important for the literature to conduct better designed studies to find the causal relationship between AGEs and pregnancy.

Keywords

Advanced glycation end-products, gestational diabetes mellitus, oxidative stress, preeclampsia, pregnancy

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