COVID-19’da Hemoglobin, Ortalama Trombosit Hacimleri ve Nötrofil Lenfosit Oranındaki Değişiklikler

Year 2023, Volume: 6 Issue: 1, 44 - 52, 28.04.2023

Adem Durmaz , Muammer Yılmaz

https://doi.org/10.54803/sauhsd.1138532

Abstract

Amaç: Dünya genelinde büyük bir salgın yapan COVID-19 hastalığında, kanda ve inflamatuvar belirteçlerde (Ortalama Trombosit Hacmi ve Nötrofil Lenfosit Oranı) meydana gelen değişimleri değerlendirmek amaçlanmıştır.
Yöntem: Çalışma, toplam 213 kişi ile yapılmıştır. Bunların 142 kişisi COVID-19 şikâyetleri nedeniyle Real Time Polimeraz Zincir Reaksiyonu (PCR) testi yapılmış ve kesin tanısı konmuş hastalardan oluşmaktadır. Benzer yaş ve özellikte hiçbir şikayet ve semptomu olmayan 71 adet sağlıklı insanın kan değerleri ile retrospektif olarak karşılaştırılmıştır.
Bulgular: COVID-19 pozitif grubun yaş ortalaması 54.62±17.71 yıl iken kontrol grubunun 50.54±15.74 yıl idi. Hasta grubunun %52,8’si (n:75) kontrol grubunun ise %54,9’u (n:39) kadınlardan oluşmaktaydı. Özellikle PCR pozitif grupta platelet sayılarında düşüş saptanmıştır ama istatiksel açıdan PCR pozitif grup ile kontrol grubu arasında hemoglobin ve platelet değerleri için anlamlı bir farklılık gözlenmemiştir (p>0,05). Ama Ortalama Trombosit Hacmi, nötrofil, lenfosit ve nötrofil lenfosit oranlarında anlamlı farklılık (p<0,01) saptanmıştır.
Sonuç: COVID-19 enfeksiyonunda gelişen sitokin fırtınası nedeniyle kanda trombosit sayılarında azalma başta olmak üzere bir dizi değişiklikler meydana gelmektedir. Özellikle yeni inflamatuvar markerlerdan olan Ortalama Trombosit Hacmi ve Nötrofil Lenfosit Oranında meydana gelen değişiklikler bu hastalığın ve prognozunun takibinde kullanılabileceğini düşünmekteyiz.

Keywords

Covid 19, hemoglobin, trombosit, nötrofil, lenfosit

Supporting Institution

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Thanks

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Changes in Hemoglobin, Mean Thrombocid Volume and Neutrophil-Lymphocyte Ratio in Covıd-19 Infection

Abstract

Objective: It is aimed to evaluate the changes in blood and inflammatory markers (Mean Platelet Volume and Neutrophil Lymphocyte Ratio) in COVID-19.
Method: We studied a total of 213 patients. 142 of them consist of patients who have undergone PCR test due to COVID-19 complaints and have a definite diagnosis. The blood values of 71 healthy people of similar age and characteristics without any complaints or symptoms were retrospectively compared.
Results: The mean age of the COVID-19(+) group was 54.62±17.71 years, while the COVID-19(-) group was 50.54±15.74 years. 52.8% (n:75) of the patient group and 54.9% (n:39) of the COVID-19(-) group were women. There was a decrease in the number of platelets especially in the PCR(+) group, but statistically no significant difference was observed between the PCR(+) group and the COVID-19(-) group for hemoglobin and platelet values (p>0.05). However, a significant difference (p <0.01) was found in Mean Platelet Volume, neutrophil, lymphocyte and Neutrophil Lymphocyte Ratio.
Conclusion: Due to the cytokine storm that develops in COVID-19 infection, a number of changes occur in the blood, especially a decrease in thrombocyte counts. We think that especially the changes in Mean Platelet Volume and Neutrophil Lymphocyte Ratio, which are new inflammatory markers, can be used in the follow-up of this disease and its prognosis.

Keywords

COVID-19, hemoglobin, platelet, neutrophil, lymphocyte

Project Number

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