İSKELET VE KALP KASLARINDA LAKTİK ASİTİN TAŞINIMI: MONOKARBOKSİL TAŞIYICI PROTEİNLER BÖLÜM I.

Abstract

Keywords

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İSKELET VE KALP KASLARINDA LAKTİK ASİTİN TAŞINIMI: MONOKARBOKSİL TAŞIYICI PROTEİNLER BÖLÜM I

Abstract

Laktik asit iskelet kasları için hem ana yakıt (oksidatif fibriller) hem de son üründür( glikolitik fibriller). Bu nedenle laktatın plazma membranında taşınımı, onun kasın içine girişi ve çıkışı için önemli bir düzenleyici mekanizmadır. Monokarboksil taşıyıcı proteinler (MCT) laktikasit, pürivik asit ve keton cisimleri gibi monokarboksilli asitleri taşıyan proton bağlantılı taşıyıcı proteinleridir. MCT’ler memelilerde aminoasit içeriğine göre belirlenmiş 14 üyeden oluşan büyük bir taşıyıcı protein ailesidir. Bu proteinlerin bazıları belirli bir dokuya özgünken,diğer bazıları birçok dokuda mevcuttur. İnsan ve sıçanların iskelet ve kalp kaslarında MCT1ve MCT4 olmak üzere iki izoform vardır. Bununla beraber iskelet kaslarında her iki izoformda (MCT1 ve MCT4) mevcutken, sıçanların kalp kasında sadece MCT1 bulunur. MCT1 ilekasın oksidatif fibril kompozisyonu arasında yüksek ilişki vardır. Kasın MCT1 içeriği ile dolaşımdan laktat alımı arasında da yüksek ilişki mevcuttur. MCT4 hızlı kasılan fibrillerle (hızlı glikolitik ve hızlı oksidatif glikolitik) sınırlıdır ve anaerobik metabolizma ile ilişkilidir. Böylece bubilgiler MCT1’in öncelikle dolaşımdan kasa, MCT4’ün ise kasdan dolaşıma laktik asitin taşınımından sorumlu olduğunu gösterir

Keywords

• Laktik asit, Monokarboksil taşıyıcı proteinler, MCT1, MCT4

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