Capparis ovata modulates ovariectomize induced-oxidative toxicity in brain, kidney and liver of aged mice

Year 2011, Volume: 3 Issue: 2, 186 - 193, 14.08.2013

Mustafa Nazıroğlu , Hamide Betül Gün Şeyma Savaş Ömer Çelik Ercan Sözbir Mehmet Okan Özkaya Seyit Ali Köse Mustafa Nazıroğlu

Abstract

Oxidative stress is a critical way of damage in various
physiological stress-induced disorders including age and
menopause. Capparis ovata (C. ovata) may useful treatment of
ovariectomize in old women because it contains flavonoids which
demonstrated as an antioxidant. The study in overiectomized
mice, as a model of menopausal status, of the effects of C. ovata
on lipid peroxidation (LP) and antioxidant levels in aged mice.
Forty female aged mice (12 months old) were randomly
divided into four groups. First group was used as control
although second group was C. ovata group. Third group was
ovariectomized group. C. ovata was given to ovariectomizeinduced
mice constituting the fourth groups for 28 days via
gastric gavage. End of the experiment, brain cortex, kidney and
liver samples were taken from all groups.
The LP levels in the brain cortex, kidney and liver in
ovariectomized group were higher than in control and C. ovata
groups whereas they were decreased by C. ovata administration.
Vitamin E concentrations in brain cortex and liver, β-carotene
concentration in liver were decreased by the ovariectomize
exposure although they were increased in the ovariectomized
group by the C. ovata administration. The vitamin A, vitamin
C, glutathione peroxidase and glutathione values in the brain
cortex, liver and kidney did not change in the four groups by
ovariectomize or C. ovata treatments.
In conclusion, the experimental ovariectomize is associated
with elevated oxidative stress although treatment with the C.
ovata induced protective effects on the oxidative stress in the
aged ovariectomized mice.

Keywords

C. ovata, menopause, antioxidant, oxidative stress, vitamin E