Musa Sapientum attenuates total antioxidant and lipid profile values in rats with indomethacin–induced gastric ulceration

Year 2013, Volume: 5 Issue: 1, 236 - 243, 12.11.2013

Adelaja Akinlolu

Abstract

This study evaluated the anti-ulcer properties of Musa Sapientum sucker. Rats of Group I received only 2mls of Normal Saline while 40mg/kg/bodyweight of Indomethacin (an ulcerogen) was administered to rats of Groups II – VI. Four hours after administrations of the ulcerogen; 5, 10 and 20mg/kg/bodyweight of Musa sapientum sucker extract and 40mg/kg/bodyweight of Omeprazole were administered orally to rats of Groups III – VI respectively. Analyses of total antioxidant and lipid profile status in the sera, stomach, kidney and liver samples of rats that received only 40mg/kg bodyweight of Indomethacin showed statistically significant increased activities of antioxidant enzymes, lipid peroxidation, total cholesterol and triglycerides. However, comparatively remedied levels of antioxidant enzymes, lipid peroxidation, total cholesterol and triglycerides were observed in the sera, stomach, kidney and liver samples of rats treated with 5, 10 and 20mg/kg/bodyweight of Musa sapientum extract; and rats that received 40mg/kg/bodyweight of Omeprazole. Non-statistically significant improved total antioxidant and lipid profile status were observed in rats treated with 5 and 20mg/kg/bodyweight of Musa sapientum extract respectively when compared with rats that received 40mg/kg/bodyweight of Omeprazole. Evaluations of creatinine, urea and bilirubin levels in sera samples of rats of Groups III – V treated with 5, 10 and 20mg/kg bodyweight of Musa sapientum sucker extract respectively showed improved kidney function tests better than those observed in rats treated with 40mg/kg bodyweight of Omeprazole. This study concluded that Musa sapientum administrations improved kidney functions, total antioxidant and lipid profile status of wistar rats in Indomethacine – induced gastric ulceration.

Keywords

Ion channels, cell biochemistry, biophysics, calcium signaling, cellular function, cellular physiology, metabolism, apoptosis, lipid peroxidation, nitric oxide synthase, ageing, antioxidants, neuropathy.

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