Research Article

CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG

Volume: 35 Number: 1 March 1, 2017
  • Huceste Çatalgil Giz
  • Sevim İşçi
  • Fatemeh Bahadori
  • Zeynep Kalaycıoğlu
  • Barbaros Akkurt

CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG

Abstract

Water solubility of curcumin is increased by PEG in ultrasound medium. Different PEG-curcumin complexes were prepared with and without using ultrasound at 250C. Curcumin concentrations of complexes were determined by UV. The surface charges of PEG-curcumin complexes were investigated by zeta measurements. Critical aggregate concentrations were determined from both UV and zeta potential measurements. Complexes prepared by ultrasound were found to be more compact and homogenous in both size and charge distribution and they also carried more curcumin. Antioxidant capacity of the complexes, determined by DPPH and FRAP methods, were higher than the capacity of curcumin itself.

Keywords

References

  1. [1] Piper, J.T., Singhal, S.S., Salameh, M., Torman, R.T., Awasthi, Y.C., Awasthi, S., “Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver”. Int. J. Biochem. Cell. Biol. 30, 445-456, 1998.
  2. [2] Rao, C.V., Rivenson, A., Simi, B., Reddy, B.S., “Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound”. Cancer Res. 55, 259-266, 1995.
  3. [3] Kawamori, T., Lubet, R., Steele, V.E., Kelloff, G.J., Kaskey, R.B., Rao, C.V., Reddy, B.S., “Chemopreventive effect of curcumin, a naturally occurring antiinflammatory agent, during the promotion/progression stages of colon cancer”. Cancer Res. 59, 597–601, 1999.
  4. [4] Cheng, A.L., Hsu, C.H., Lin, J.K., Hsu, M.M., Ho, Y.F., Shen, T.S., Ko, J.Y., Lin, J.T., Lin, B.R., Ming-Shiang, W., Yu, H.S., Jee, S.H., Chen, G.S., Chen, T.M., Chen, C.A., Lai, M.K., Pu, Y.S., Pan, M.H., Wang, Y.J., Tsai, C.C., Hsieh, C.Y., “Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions”. Anticancer Res. 21, 2895–2900, 2001.
  5. [5] Aggarwal, B.B., Kumar, A., Bharti, A.C., “Anticancer potential of curcumin, preclinical and clinical studies”. Anticancer Res. 23, 363–398, 2003.
  6. [6] Duvoix, A., Blasius, R., Delhalle, S., Schnekenburger, M., Morceau, F., Henry, E., Dicato, M., Diederich, M., “Chemopreventive and therapeutic effects of curcumin”, Cancer Letters. 223, 181–190, 2005.
  7. [7] Modasiya, M.K., Patel, V.M., “Studies on solubility of curcumin”, Int J of Pharm Life Sci (IJPLS), 3,1490-1497, 2012.
  8. [8] Kaewnopparat, N., Kaewnopparat, S., Jangwang, A., Maneenaun, D., Chuchome, T., Panichayupakaranant, P., “Increased Solubility, Dissolution and Physico chemical Studies of Curcumin-Polyvinylpyrrolidone K-30 Solid Dispersions”, World Academy of Science, Engineering and Technology, 2009, 31, 225-230.

Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Huceste Çatalgil Giz This is me
Türkiye

Sevim İşçi This is me
Türkiye

Fatemeh Bahadori This is me
Türkiye

Zeynep Kalaycıoğlu This is me
Türkiye

Barbaros Akkurt This is me
Türkiye

Publication Date

March 1, 2017

Submission Date

December 18, 2016

Acceptance Date

January 23, 2017

Published in Issue

Year 2017 Volume: 35 Number: 1

APA
Çatalgil Giz, H., İşçi, S., Bahadori, F., Kalaycıoğlu, Z., & Akkurt, B. (2017). CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG. Sigma Journal of Engineering and Natural Sciences, 35(1), 47-58. https://izlik.org/JA76AF45ZU
AMA
1.Çatalgil Giz H, İşçi S, Bahadori F, Kalaycıoğlu Z, Akkurt B. CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG. SIGMA. 2017;35(1):47-58. https://izlik.org/JA76AF45ZU
Chicago
Çatalgil Giz, Huceste, Sevim İşçi, Fatemeh Bahadori, Zeynep Kalaycıoğlu, and Barbaros Akkurt. 2017. “CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG”. Sigma Journal of Engineering and Natural Sciences 35 (1): 47-58. https://izlik.org/JA76AF45ZU.
EndNote
Çatalgil Giz H, İşçi S, Bahadori F, Kalaycıoğlu Z, Akkurt B (March 1, 2017) CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG. Sigma Journal of Engineering and Natural Sciences 35 1 47–58.
IEEE
[1]H. Çatalgil Giz, S. İşçi, F. Bahadori, Z. Kalaycıoğlu, and B. Akkurt, “CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG”, SIGMA, vol. 35, no. 1, pp. 47–58, Mar. 2017, [Online]. Available: https://izlik.org/JA76AF45ZU
ISNAD
Çatalgil Giz, Huceste - İşçi, Sevim - Bahadori, Fatemeh - Kalaycıoğlu, Zeynep - Akkurt, Barbaros. “CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG”. Sigma Journal of Engineering and Natural Sciences 35/1 (March 1, 2017): 47-58. https://izlik.org/JA76AF45ZU.
JAMA
1.Çatalgil Giz H, İşçi S, Bahadori F, Kalaycıoğlu Z, Akkurt B. CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG. SIGMA. 2017;35:47–58.
MLA
Çatalgil Giz, Huceste, et al. “CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG”. Sigma Journal of Engineering and Natural Sciences, vol. 35, no. 1, Mar. 2017, pp. 47-58, https://izlik.org/JA76AF45ZU.
Vancouver
1.Huceste Çatalgil Giz, Sevim İşçi, Fatemeh Bahadori, Zeynep Kalaycıoğlu, Barbaros Akkurt. CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG. SIGMA [Internet]. 2017 Mar. 1;35(1):47-58. Available from: https://izlik.org/JA76AF45ZU

IMPORTANT NOTE: JOURNAL SUBMISSION LINK https://eds.yildiz.edu.tr/sigma/