HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION

Ayça Bal; Erdal Cevher; Saadet Kevser Pabuccuoğlu

HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION

Abstract

The aim of this study is to synthesize and characterize the new hydroxyl-functionalized hyperbranched aliphatic polyesters with various generations for potential use in cancer therapy as targeted drug delivery system. For this purpose, a series of novel hydroxyl-functionalized hyperbranched aliphatic polyesters (HBPs) based on 2,2-bis(hydroxymethyl)butyric acid (Bis-HBA) as AB2-type monomer and 1,1,1-tris(hydroxymethyl)propane (TMP) as B3 core molecule were synthesized via acid catalyzed polyesterification reaction in three different generations and named as HBP-2G, HBP-4G and HBP-5G. The synthesis route was a simple pseudo-one-step reaction where AB2-type monomer and B3 core molecule are polycondensed in the presence of an acid catalyst. The chemical structures of the synthesized HBPs were confirmed by FTIR, 13C NMR and 1H NMR analysis. The degree of branching (DB) of the HBPs as calculated from 1H NMR results were between 0.87 and 0.92. These results showed that all synthesized HBPs had a high degree of branching. TGA measurements exhibited that all of HBPs had similar and good thermal stability. Glass transition temperatures (Tg) of samples were identified using DSC analysis and were found to be between 66.2 °C and 69.1 °C. Low generation HBPs have considerably higher solubility in organic solvents than high generation HBPs. All synthesized HBPs displayed extremely low water solubility but extremely high solubility in dimethyl sulfoxide. It was concluded that new HBPs which were synthesized in this study have reasonable characteristics for hyperbranched polymers applications.

Keywords

References

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Ayça Bal This is me
Türkiye

Erdal Cevher This is me
Türkiye

Saadet Kevser Pabuccuoğlu This is me
Türkiye

Publication Date

June 1, 2017

Submission Date

December 14, 2016

Acceptance Date

March 23, 2017

Published in Issue

Year 2017 Volume: 35 Number: 2

IZ

https://izlik.org/JA25MZ89AB

Cite

RIS / Bibtex

APA

Bal, A., Cevher, E., & Pabuccuoğlu, S. K. (2017). HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION. Sigma Journal of Engineering and Natural Sciences, 35(2), 239-251. https://izlik.org/JA25MZ89AB

AMA

1.Bal A, Cevher E, Pabuccuoğlu SK. HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION. SIGMA. 2017;35(2):239-251. https://izlik.org/JA25MZ89AB

Chicago

Bal, Ayça, Erdal Cevher, and Saadet Kevser Pabuccuoğlu. 2017. “HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION”. Sigma Journal of Engineering and Natural Sciences 35 (2): 239-51. https://izlik.org/JA25MZ89AB.

EndNote

Bal A, Cevher E, Pabuccuoğlu SK (June 1, 2017) HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION. Sigma Journal of Engineering and Natural Sciences 35 2 239–251.

IEEE

[1]A. Bal, E. Cevher, and S. K. Pabuccuoğlu, “HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION”, SIGMA, vol. 35, no. 2, pp. 239–251, June 2017, [Online]. Available: https://izlik.org/JA25MZ89AB

ISNAD

Bal, Ayça - Cevher, Erdal - Pabuccuoğlu, Saadet Kevser. “HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION”. Sigma Journal of Engineering and Natural Sciences 35/2 (June 1, 2017): 239-251. https://izlik.org/JA25MZ89AB.

JAMA

1.Bal A, Cevher E, Pabuccuoğlu SK. HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION. SIGMA. 2017;35:239–251.

MLA

Bal, Ayça, et al. “HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION”. Sigma Journal of Engineering and Natural Sciences, vol. 35, no. 2, June 2017, pp. 239-51, https://izlik.org/JA25MZ89AB.

Vancouver

1.Ayça Bal, Erdal Cevher, Saadet Kevser Pabuccuoğlu. HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION. SIGMA [Internet]. 2017 Jun. 1;35(2):239-51. Available from: https://izlik.org/JA25MZ89AB