PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE

Hediye Irem Ozgunduz; Hava Gizem Kandılcı; Nil Acaralı; Hanifi Sarac

PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE

Abstract

The aim of controlled insulin delivery study experiments is to produce the smart hydrogel to use insulin release for human body. Insulin entrapped p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragit L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker and new alternative ways were worked on to find and develop. Taguchi method was used and optimum synthesis conditions were determined. Insulin was entrapped into hydrogels as synthesis. After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.

Keywords

References

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Hediye Irem Ozgunduz This is me
Türkiye

Hava Gizem Kandılcı This is me
Türkiye

Nil Acaralı This is me
Türkiye

Hanifi Sarac This is me
Türkiye

Publication Date

March 1, 2016

Submission Date

July 3, 2015

Acceptance Date

November 17, 2015

Published in Issue

Year 2016 Volume: 34 Number: 1

IZ

https://izlik.org/JA32JW92TR

Cite

RIS / Bibtex

APA

Ozgunduz, H. I., Kandılcı, H. G., Acaralı, N., & Sarac, H. (2016). PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE. Sigma Journal of Engineering and Natural Sciences, 34(1), 115-122. https://izlik.org/JA32JW92TR

AMA

1.Ozgunduz HI, Kandılcı HG, Acaralı N, Sarac H. PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE. SIGMA. 2016;34(1):115-122. https://izlik.org/JA32JW92TR

Chicago

Ozgunduz, Hediye Irem, Hava Gizem Kandılcı, Nil Acaralı, and Hanifi Sarac. 2016. “PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE”. Sigma Journal of Engineering and Natural Sciences 34 (1): 115-22. https://izlik.org/JA32JW92TR.

EndNote

Ozgunduz HI, Kandılcı HG, Acaralı N, Sarac H (March 1, 2016) PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE. Sigma Journal of Engineering and Natural Sciences 34 1 115–122.

IEEE

[1]H. I. Ozgunduz, H. G. Kandılcı, N. Acaralı, and H. Sarac, “PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE”, SIGMA, vol. 34, no. 1, pp. 115–122, Mar. 2016, [Online]. Available: https://izlik.org/JA32JW92TR

ISNAD

Ozgunduz, Hediye Irem - Kandılcı, Hava Gizem - Acaralı, Nil - Sarac, Hanifi. “PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE”. Sigma Journal of Engineering and Natural Sciences 34/1 (March 1, 2016): 115-122. https://izlik.org/JA32JW92TR.

JAMA

1.Ozgunduz HI, Kandılcı HG, Acaralı N, Sarac H. PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE. SIGMA. 2016;34:115–122.

MLA

Ozgunduz, Hediye Irem, et al. “PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE”. Sigma Journal of Engineering and Natural Sciences, vol. 34, no. 1, Mar. 2016, pp. 115-22, https://izlik.org/JA32JW92TR.

Vancouver

1.Hediye Irem Ozgunduz, Hava Gizem Kandılcı, Nil Acaralı, Hanifi Sarac. PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE. SIGMA [Internet]. 2016 Mar. 1;34(1):115-22. Available from: https://izlik.org/JA32JW92TR