SYNTHESIS OF BROMINATED QUINOLINES

Year 2015, Volume: 33 Issue: 1, 8 - 15, 01.03.2015

Salih Ökten Dilek Eyigün Osman Çakmak

https://izlik.org/JA78NZ86WW

Abstract

In this study, bromination reactions of 1,2,3,4-tetrahydroquinoline by molecular bromine and aromatization reactions of brominated tetrahydroquinolines were reinvestigated. Optimal reaction conditions were established for 6-Bromo-1,2,3,4-tetrahydroquinoline (6-BrTHQ ) and 6,8-dibromo-1,2,3,4-tetrahydroquinoline (6,8-diBrTHQ). Improved yields and more shortened reaction times were described for the conversion of 6-BrTHQ and 6,8-diBrTHQ into 6-bromoquinoline and 6,8-dibromoquinoline.

Keywords

Quinoline , tetrahydroquinoline , bromoquinoline , bromination , aromatization , DDQ

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