EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES

Hatice İmran Güngördü; Nil Erge Akkaya; Ahmet Giz; Huceste Çatalgil Giz

EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES

Abstract

Ascorbic acid loaded polyvinylpyrrolidone tablets are prepared and ascorbic acid release profiles are monitored by the automatic continuous online monitoring of polymerization (ACOMP) system. Three different molecular weights of polymers are used in tablets. Parallel experiments are performed using powder samples. Drug release from tablets is investigated as zeroth and halfth order processes for the dissolution step and a first order process for the diffusion step. Powder samples are investigated on the basis of a first order diffusion model. Kinetic rate constants for the dissolution and diffusion processes are calculated. Release profiles are found to depend strongly on the molecular weights of the polymers. Higher molecular weights are found to slow down both the dissolution and the diffusion processes. Diffusion constants are compared with independent viscosity measurements.

Keywords

References

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Details

Primary Language

English

Subjects

Engineering

Journal Section

Research Article

Authors

Hatice İmran Güngördü This is me
Türkiye

Nil Erge Akkaya This is me
Türkiye

Ahmet Giz This is me
Türkiye

Huceste Çatalgil Giz This is me
Türkiye

Publication Date

September 1, 2015

Submission Date

April 7, 2015

Acceptance Date

May 14, 2015

Published in Issue

Year 2015 Volume: 33 Number: 3

IZ

https://izlik.org/JA59TU58PJ

Cite

RIS / Bibtex

APA

Güngördü, H. İ., Akkaya, N. E., Giz, A., & Çatalgil Giz, H. (2015). EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES. Sigma Journal of Engineering and Natural Sciences, 33(3), 407-416. https://izlik.org/JA59TU58PJ

AMA

1.Güngördü Hİ, Akkaya NE, Giz A, Çatalgil Giz H. EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES. SIGMA. 2015;33(3):407-416. https://izlik.org/JA59TU58PJ

Chicago

Güngördü, Hatice İmran, Nil Erge Akkaya, Ahmet Giz, and Huceste Çatalgil Giz. 2015. “EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES”. Sigma Journal of Engineering and Natural Sciences 33 (3): 407-16. https://izlik.org/JA59TU58PJ.

EndNote

Güngördü Hİ, Akkaya NE, Giz A, Çatalgil Giz H (September 1, 2015) EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES. Sigma Journal of Engineering and Natural Sciences 33 3 407–416.

IEEE

[1]H. İ. Güngördü, N. E. Akkaya, A. Giz, and H. Çatalgil Giz, “EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES”, SIGMA, vol. 33, no. 3, pp. 407–416, Sept. 2015, [Online]. Available: https://izlik.org/JA59TU58PJ

ISNAD

Güngördü, Hatice İmran - Akkaya, Nil Erge - Giz, Ahmet - Çatalgil Giz, Huceste. “EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES”. Sigma Journal of Engineering and Natural Sciences 33/3 (September 1, 2015): 407-416. https://izlik.org/JA59TU58PJ.

JAMA

1.Güngördü Hİ, Akkaya NE, Giz A, Çatalgil Giz H. EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES. SIGMA. 2015;33:407–416.

MLA

Güngördü, Hatice İmran, et al. “EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES”. Sigma Journal of Engineering and Natural Sciences, vol. 33, no. 3, Sept. 2015, pp. 407-16, https://izlik.org/JA59TU58PJ.

Vancouver

1.Hatice İmran Güngördü, Nil Erge Akkaya, Ahmet Giz, Huceste Çatalgil Giz. EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES. SIGMA [Internet]. 2015 Sep. 1;33(3):407-16. Available from: https://izlik.org/JA59TU58PJ