Production, characterization and antioxidant activity evaluation of quercetin loaded PLGA nanofibers

Seçil Kaya; Serap Derman

Production, characterization and antioxidant activity evaluation of quercetin loaded PLGA nanofibers

Abstract

Quercetin is a flavonoid which is known to have antioxidant, anticancer and antimicrobial activities and found high ratio in many plants and nutrients. As quercetin has a superior ability to scavenging of reactive oxygen species, its use in wound dressing studies is increasing. Electrospun membranes are seen to be advantageous in terms of controlled and continuous drug release, water absorption and mimicry to intercellular matrix elements. In this study, PLGA nanofibers are produced by electrospinning method. In their SEM images, it is observed that PLGA nanofibers are successfully produced with average diameter of 500±20 nm and they are bead-free and randomly. Quercetin was loaded onto the PLGA membrane by spraying method to ensure that the fibers were physically attached onto the surface. FTIR spectroscopy analysis showed that quercetin was successfully loaded onto the nanofibers. In the swelling study, it was found that water absorption capability of PLGA membrane is 300±30%. Drug release studies were performed with quercetin-loaded PLGA nanofibers and it was determined that quercetin was completely released in 7 days. Antioxidant activity of quercetin loaded PLGA nanofibers was tested by DPPH method and it was showed 85.1±0.8% antioxidant activity.

Keywords

References

The article references can be accessed from the .pdf file.

Details

Primary Language

English

Subjects

Engineering

Journal Section

Research Article

Authors

Seçil Kaya This is me
0000-0001-6614-6641
Türkiye

Serap Derman ^* This is me
0000-0002-6662-6642
Türkiye

Publication Date

June 6, 2022

Submission Date

September 27, 2021

Acceptance Date

October 11, 2021

Published in Issue

Year 2022 Volume: 40 Number: 2

IZ

https://izlik.org/JA64RJ45TT

Cite

RIS / Bibtex

APA

Kaya, S., & Derman, S. (2022). Production, characterization and antioxidant activity evaluation of quercetin loaded PLGA nanofibers. Sigma Journal of Engineering and Natural Sciences, 40(2), 433-440. https://izlik.org/JA64RJ45TT

AMA

1.Kaya S, Derman S. Production, characterization and antioxidant activity evaluation of quercetin loaded PLGA nanofibers. SIGMA. 2022;40(2):433-440. https://izlik.org/JA64RJ45TT

Chicago

Kaya, Seçil, and Serap Derman. 2022. “Production, Characterization and Antioxidant Activity Evaluation of Quercetin Loaded PLGA Nanofibers”. Sigma Journal of Engineering and Natural Sciences 40 (2): 433-40. https://izlik.org/JA64RJ45TT.

EndNote

Kaya S, Derman S (June 1, 2022) Production, characterization and antioxidant activity evaluation of quercetin loaded PLGA nanofibers. Sigma Journal of Engineering and Natural Sciences 40 2 433–440.

IEEE

[1]S. Kaya and S. Derman, “Production, characterization and antioxidant activity evaluation of quercetin loaded PLGA nanofibers”, SIGMA, vol. 40, no. 2, pp. 433–440, June 2022, [Online]. Available: https://izlik.org/JA64RJ45TT

ISNAD

Kaya, Seçil - Derman, Serap. “Production, Characterization and Antioxidant Activity Evaluation of Quercetin Loaded PLGA Nanofibers”. Sigma Journal of Engineering and Natural Sciences 40/2 (June 1, 2022): 433-440. https://izlik.org/JA64RJ45TT.

JAMA

1.Kaya S, Derman S. Production, characterization and antioxidant activity evaluation of quercetin loaded PLGA nanofibers. SIGMA. 2022;40:433–440.

MLA

Kaya, Seçil, and Serap Derman. “Production, Characterization and Antioxidant Activity Evaluation of Quercetin Loaded PLGA Nanofibers”. Sigma Journal of Engineering and Natural Sciences, vol. 40, no. 2, June 2022, pp. 433-40, https://izlik.org/JA64RJ45TT.

Vancouver

1.Seçil Kaya, Serap Derman. Production, characterization and antioxidant activity evaluation of quercetin loaded PLGA nanofibers. SIGMA [Internet]. 2022 Jun. 1;40(2):433-40. Available from: https://izlik.org/JA64RJ45TT