The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model

Emel Serdaroğlu Kaşikçi; Burcu Çevreli; Tayfun Gözler; Muhsin Konuk

The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model

Abstract

This study evaluates the protective effect of Hesperidin (HES), flavanoglycone, during pre-ec-lampsia developed pregnancy. The pregnant rats were randomly divided into five groups as Control, L-NAME (25 mg/kg), HES (100 mg/kg), L-NAME-HES and L-NAME P-HES. After the 13th day of pregnancy, the chemicals were administrated until the 20th day. 20 days after the offspring’s birth, they were separated from their mothers and all rats were sacrificed after 6 weeks’ time. Serum samples were analyzed for levels of Glutathione (GSH), lipid peroxidation (LPO), and neuron-specific enolase (NSE) activity. Urine samples were analyzed for the pro-teinuria. While Proteinuria and LPO level increasing, GSH levels decreased in the L-NAME group when compared to the Control. As we compared L-NAME group with the L-NAME-HES and L-NAME P-HES groups, the GSH levels increased significantly while LPO levels in the HES, L-NAME-HES, L-NAME P-HES groups were decreasing. The NSE activity signifi-cantly increased in the L-NAME group compared to the Control. In contrast to the L-NAME group, its activity decreased in HES, L-NAME-HES and L-NAME P-HES groups significantly. Briefly, it can be said that HES has a significant effect on both the LPO levels and the NSE activity in the case of pre-eclampsia.

Keywords

References

REFERENCES
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Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Research Article

Authors

Emel Serdaroğlu Kaşikçi This is me
0000-0003-1566-5788
Türkiye

Burcu Çevreli This is me
0000-0001-6337-4999
Türkiye

Tayfun Gözler This is me
0000-0001-8548-8516
Türkiye

Muhsin Konuk This is me
Türkiye

Publication Date

April 30, 2024

Submission Date

January 19, 2022

Acceptance Date

July 1, 2022

Published in Issue

Year 2024 Volume: 42 Number: 2

IZ

https://izlik.org/JA85ML23NE

Cite

RIS / Bibtex

APA

Serdaroğlu Kaşikçi, E., Çevreli, B., Gözler, T., & Konuk, M. (2024). The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model. Sigma Journal of Engineering and Natural Sciences, 42(2), 497-502. https://izlik.org/JA85ML23NE

AMA

1.Serdaroğlu Kaşikçi E, Çevreli B, Gözler T, Konuk M. The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model. SIGMA. 2024;42(2):497-502. https://izlik.org/JA85ML23NE

Chicago

Serdaroğlu Kaşikçi, Emel, Burcu Çevreli, Tayfun Gözler, and Muhsin Konuk. 2024. “The Effect of Hesperidin on Neuron-Specific Enolase and Oxidative Damage in the Pre-Eclampsia Model”. Sigma Journal of Engineering and Natural Sciences 42 (2): 497-502. https://izlik.org/JA85ML23NE.

EndNote

Serdaroğlu Kaşikçi E, Çevreli B, Gözler T, Konuk M (April 1, 2024) The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model. Sigma Journal of Engineering and Natural Sciences 42 2 497–502.

IEEE

[1]E. Serdaroğlu Kaşikçi, B. Çevreli, T. Gözler, and M. Konuk, “The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model”, SIGMA, vol. 42, no. 2, pp. 497–502, Apr. 2024, [Online]. Available: https://izlik.org/JA85ML23NE

ISNAD

Serdaroğlu Kaşikçi, Emel - Çevreli, Burcu - Gözler, Tayfun - Konuk, Muhsin. “The Effect of Hesperidin on Neuron-Specific Enolase and Oxidative Damage in the Pre-Eclampsia Model”. Sigma Journal of Engineering and Natural Sciences 42/2 (April 1, 2024): 497-502. https://izlik.org/JA85ML23NE.

JAMA

1.Serdaroğlu Kaşikçi E, Çevreli B, Gözler T, Konuk M. The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model. SIGMA. 2024;42:497–502.

MLA

Serdaroğlu Kaşikçi, Emel, et al. “The Effect of Hesperidin on Neuron-Specific Enolase and Oxidative Damage in the Pre-Eclampsia Model”. Sigma Journal of Engineering and Natural Sciences, vol. 42, no. 2, Apr. 2024, pp. 497-02, https://izlik.org/JA85ML23NE.

Vancouver

1.Emel Serdaroğlu Kaşikçi, Burcu Çevreli, Tayfun Gözler, Muhsin Konuk. The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model. SIGMA [Internet]. 2024 Apr. 1;42(2):497-502. Available from: https://izlik.org/JA85ML23NE