Research Article
BibTex RIS Cite

SYNTHESIS OF BROMINATED QUINOLINES

Year 2015, Volume: 33 Issue: 1, 8 - 15, 01.03.2015

Abstract

In this study, bromination reactions of 1,2,3,4-tetrahydroquinoline by molecular bromine and aromatization reactions of brominated tetrahydroquinolines were reinvestigated. Optimal reaction conditions were established for 6-Bromo-1,2,3,4-tetrahydroquinoline (6-BrTHQ ) and 6,8-dibromo-1,2,3,4-tetrahydroquinoline (6,8-diBrTHQ). Improved yields and more shortened reaction times were described for the conversion of 6-BrTHQ and 6,8-diBrTHQ into 6-bromoquinoline and 6,8-dibromoquinoline.

References

  • [1] Kirsch, R., Kleim, J. P., Ries, G., Rosenstock, B., Roesner, M., Winkler, I. DE Patent 19,613,591, (1997).
  • [2] Srivastava, S. K., Chauhan, P. M. S., Bhaduri, A. P., Fatima, N., Chatterjee, R. J. Med. Chem., 43, 2275, (2000).
  • [3] Desai, P. K., Desai, P., Machhi, D., Desai, C. M., Patel, D. Indian J. Chem. Sect. B, 35(B), 871, (1996).
  • [4] Muscia, G. C., Bollini, M., Carnevale, J. P., Bruno, A. M., Asis, S. E. Tetrahedron Lett., 47, 8811, (2006).
  • [5] Agarwal, A. K., Jenekhe, S. A. Macromolecules, 24, 6806 (1991).
  • [6] Zhang, X., Shetty, A. S., Jenekhe, S. A. Macromolecules, 32, 7422 (1999).
  • [7] Zhang, N., Wu, B.,Powell, D., Wissner, A., Floyd, M.B., Kovacs, E.D., Toral-Barza, L., Kohler, C. Bioorg. Med. Chem. Lett., 10, 2825-2828, (2000).
  • [8] Jenekhe, S. A., Lu, L., Alam, M. M. Macromolecules, 34, 7315. (2001).
  • [9] Solomon, V. R., Lee, H. Eur. J. Pharmacol., 625, 220, (2009).
  • [10] Boschelli, D.H., Wang, D.Y., Ye, F., Wu, B., Zhang, N., Dutia, M., Powell D. W., Wissner, A., Arndt, K., Weber, J.M., Boschelli, J. Med. Chem., 44, 822-833, (2001).
  • [11] Company of a Chemistry Partner of Drug Discovery “BioBloks inc.”, 2002, San Diego, CA, USA. http://www.bioblocks.com/quinolines.html, [Erişim tarihi; 26 Şubat 2014].
  • [12] Şahin, A., Çakmak, O., Demirtaş, İ., Ökten, S., Tutar, A., Tetrahedron, 64 (43), 10068-10074 (2008).
  • [13] Ökten, S, Çakmak O, Erenler R, Tekin Ş, Yüce Ö., Turk. J. Chem. 37, 896-908 (2013).
There are 13 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Salih Ökten This is me

Dilek Eyigün This is me

Osman Çakmak This is me

Publication Date March 1, 2015
Submission Date July 19, 2014
Published in Issue Year 2015 Volume: 33 Issue: 1

Cite

Vancouver Ökten S, Eyigün D, Çakmak O. SYNTHESIS OF BROMINATED QUINOLINES. SIGMA. 2015;33(1):8-15.

IMPORTANT NOTE: JOURNAL SUBMISSION LINK https://eds.yildiz.edu.tr/sigma/