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Evaluation of properties for synthetic polymers in medicine

Year 2024, Volume: 42 Issue: 4, 1315 - 1324, 01.08.2024

Abstract

Today, the transformation of polymers into useful structures for the human body in medical field has been an interesting subject that affected everyone. Synthetic polymers have a wide range of uses in the health sector such as coating, cardiovascular, orthodontic surgery, tissue engineering, implant, and drug carrier with the development of technology. These polymers are known as polymers with various characteristics and applications artificially synthesized in accordance with chemical and thermodynamic laws. The polymers in health sector have a share of 41% in drug and release studies, 18% in treatment with therapy applications, 10% in vaccine production, 31% in studies on new approaches in this field. Synthetic polymers have ability to be produced cheaply and easily in large quantities. In this study, synthetic poly-mers such as polyethylene glycol, polyvinyl alcohol, polyurethane, polyolefin, polytetrafluo-roethylene, silicone, polyvinyl chloride, poly-methyl methacrylate, polyester, polyamide and poly-lactic acid were investigated and details regarding the applications with explications of polymers were provided. It was seen that synthetic polymers could be evaluated in treatment of cancer and chronic diseases by determining the most appropriate methods and techniques with biocompatible, biodegradable, non-toxic materials.

References

  • References
  • [1] Rodriguez F, Cohen C, Ober CK, Archer LA. Principles of Polymer Systems. 6th ed. New York: CRC Press; 2015. [CrossRef]
  • [2] Mehmood A, Raina N, Phakeenuya V, Wonganu B, Cheenkachorn K. The current status and market trend of polylactic acid as biopolymer: Awareness and needs for sustainable development. Mater Today Chem 2022;72:30493055. [CrossRef]
  • [3] Saldívar-Guerra E, Vivaldo-Lima E. Introduction to Polymers and Polymer Types. In: Saldívar-Guerra E, Vivaldo-Lima E, editors. Handbook of polymer synthesis, characterization, and processing. New Jersey: Wiley; 2013. p. 144. [CrossRef]
  • [4] Suamte L, Tirkey A, Jayasekhar Babu P. Design of 3D smart scaffolds using natural, synthetic and hybrid derived polymers for skin regenerative applications. Smart Mater Med 2022;4:243256. [CrossRef]
  • [5] Sharma S, Aiswarya T, Mirza I, Saha S. Biocompatible polymers and their applications. In: Hashmi MSJ, editor. Encyclopedia of Materials: Plastics and Polymers. Amsterdam: Elsevier; 2022. p. 796819. [CrossRef]
  • [6] Orchin M, Macomber RS, Pinhas AR, Wilson RM. The vocabulary and concepts of organic chemistry. New Jersey: John Wiley & Sons Inc; 2005. p. 291342. [CrossRef]
  • [7] Xanthos M. Polymers and polymer composites. In: Xanthos M, editor. Functional Fillers for Plastics. New Jersey: Wiley; 2005. p. 116. [CrossRef]
  • [8] Maitz M. Applications of synthetic polymers in clinical medicine. Biosurf Biotribol 2015;1:161176. [CrossRef]
  • [9] Okamoto M, John B. Synthetic biopolymer nanocomposites for tissue engineering scaffolds. Prog Polym Sci 2013;38:14871503. [CrossRef]
  • [10] Noel J, Jannot Y, Métivier C, Sgreva NR. Thermal characterization of polyethylene glycol 600 in liquid and solid phase and across the phase transition. Thermochim Acta 2022;716:179326. [CrossRef]
  • [11] Hu J, Liu S. Emerging trends of discrete Poly (ethylene glycol) in biomedical applications. Curr Opin Biomed Eng 2022;24:100419. [CrossRef]
  • [12] Yue H, Zhao Y, Ma X, Gong J. Ethylene glycol: Properties, synthesis, and applications. Chem Soc Rev 2012;41:42184244. [CrossRef]
  • [13] Zhu L, Feng L, Luo H, Dong RS, Wang MY, Yao G, et al. Characterization of polyvinyl alcohol-nanocellulose composite film and its release effect on tetracycline hydrochloride. Ind Crops Prod 2022;188:115723. [CrossRef]
  • [14] Zhang R, Zhang D, Sun X, Song X, Yan KC, Liang H. Polyvinyl alcohol/gelatin hydrogels regulate cell adhesion and chromatin accessibility. Int J Biol Macromol 2022;219:672684.
  • [15] Koyani RD. Synthetic polymers for microneedle synthesis: From then to now. J Drug Deliv Sci Technol 2020;60:102071. [CrossRef]
  • [16] Li M, Fang H, Zhang C, Du M, Wang F. Study on the new polyurethane material suitable for foaming in water. Constr Build Mater 2022;354:129163. [CrossRef]
  • [17] Yuan L, Zhou W, Shen Y, Li Z. Chemically recyclable polyurethanes based on bio-renewable γ-butyrolactone: From thermoplastics to elastomers. Polym Degrad Stab 2022;204:110116. [CrossRef]
  • [18] Elgharbawy AS, Ali RM. A comprehensive review of the polyolefin composites and their properties. Heliyon 2022;8:e09932. [CrossRef]
  • [19] Cai Y, Zheng J, Hu Y, Wei J, Fan H. The preparation of polyolefin elastomer functionalized with polysiloxane and its effect in ethylene-propylene-diene monomer/silicon rubber blends. Eur Polym J 2022;177:111468. [CrossRef]
  • [20] Zhu C, Su Q, Wei Z, Wang X, Long S, Zhang G, et al. Poly (arylene sulfide sulfone)/polytetrafluoroethylene composite film: Thermal, mechanical, hydrophobic and low dielectric constant properties. Mater Lett 2023;330:133306. [CrossRef]
  • [21] Fitriani SW, Ikeda S, Tani M, Yajima H, Furuta H, Hatta A. Hydrophilization of polytetrafluoroethylene using an atmospheric-pressure plasma of argon gas with water–ethanol vapor. Mater Chem Phys 2022;282:125974. [CrossRef]
  • [22] Yang H, Wang Y, Wang Z, Yuan S, Niu C, Liu Y, et al. Effect of polytetrafluoroethylene nanoplastics on combined inhibition of ciprofloxacin and bivalent copper on nitrogen removal, sludge activity and microbial community in sequencing batch reactor. Bioresour Technol 2022;360:127627. [CrossRef]
  • [23] Chi H, Wang S, Li T, Li Z. Recent progress in using hybrid silicon polymer composites for wastewater treatment. Chemosphere 2021;263:128380. [CrossRef]
  • [24] Putrawan IDGA, Indarto A, Octavia Y. Thermal stabilization of polyvinyl chloride by calcium and zinc carboxylates derived from byproduct of palm oil refining. Heliyon 2022;8:e10079. [CrossRef]
  • [25] Polaskova M, Sedlacek T, Kasparkova V, Filip P. Substantial drop of plasticizer migration from polyvinyl chloride catheters using co-extruded thermoplastic polyurethane layers. Mater Today Commun 2022;32:103895. [CrossRef]
  • [26] Kaur H, Thakur A. Applications of poly (methyl methacrylate) polymer in dentistry: A review. Mater Today Proc 2022;50:16191625. [CrossRef]
  • [27] Thirumala Patil M, Lakshminarasimhan S, Santhosh G. Optical and thermal studies of host Poly (methyl methacrylate) (PMMA) based nanocomposites: A review. Mater Today Proc 2021;46:25642571. [CrossRef]
  • [28] Chen J, Jia K, Zhao Q, You H, Chen Z, Shi L, et al. Intelligent polyester metafabric for scalable personal hydrothermal self-adaptive adjustment. Chem Eng J 2023;451:138875.
  • [29] Pugliese R, Beltrami B, Regondi S, Lunetta C. Polymeric biomaterials for 3D printing in medicine: An overview. Ann 3D Print Med 2021;2:100011. [CrossRef]
  • [30] Kumar Maurya A, Kumar S, Singh M, Manik G. Polyamide fiber reinforced polymeric composites: A short review. Mater Today Proc 2023;80:98103. [CrossRef]
  • [31] Rao SH, Harini B, Shadamarshan RPK, Balagangadharan K, Selvamurugan N. Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering. Int J Biol Macromol 2018;110:8896. [CrossRef]
  • [32] Terzopoulou Z, Zamboulis A, Koumentakou I, Michailidou G, Noordam MJ, Bikiaris DN. Biocompatible synthetic polymers for tissue engineering purposes. Biomacromolecules 2022;23:18411863. [CrossRef]
  • [33] Gaaz TS, Sulong AB, Akhtar MN, Kadhum AA, Mohamad AB, Al-Amiery AA. Properties and applications of polyvinyl alcohol, halloysite nanotubes and their nanocomposites. Molecules 2015;20:2283322847. [CrossRef]
  • [34] Foster LJ. PEGylation and BioPEGylation of Polyhydroxyalkanoates: Synthesis, Characterisation and Applications. London, UK: IntechOpen; 2010. p. 243249.
  • [35] Pierre TS, Chiellini E. Review: Biodegradability of synthetic polymers used for medical and pharmaceutical applications. J Bioact Compat Polym 1986;1:467497. [CrossRef]
  • [36] Gunatillake P, Mayadunne R, Adhikari R. Recent developments in biodegradable synthetic polymers. Biotechnol Annu Rev 2006;12:301347. [CrossRef]
  • [37] Huang HJ, Tsai YL, Lin SH, Hsu SH. Smart polymers for cell therapy and precision medicine. J Biomed Sci 2019;26:73. [CrossRef]
  • [38] Suhail M, Shih CM, Liu JY, Hsieh WC, Lin YW, Lin IL, et al. Synthesis of glutamic acid/polyvinyl alcohol-based hydrogels for controlled drug release: In-vitro characterization and in-vivo evaluation. J Drug Deliv Sci Technol 2022;75:103715. [CrossRef]
  • [39] Bhatt S, Pathak A, Grover P, Bharadwaj A, Bhatia D, Tomar R, et al. Different aspects of polymers – A review article. Mater Today Proc 2022;64:14901495. [CrossRef]
  • [40] Chaudhuri A, Ramesh K, Kumar DN, Dehari D, Singh S, Kumar D, et al. Polymeric micelles: A novel drug delivery system for the treatment of breast cancer. J Drug Deliv Sci Technol. 2022;77:103886. [CrossRef]
  • [41] Anju S, Prajitha N, Sukanya V, Mohanan P. Complicity of degradable polymers in health-care applications. Mater Today Chem 2020;16:100236. [CrossRef]
  • [42] Shakya AK, Nandakumar KS. Polymers as immunological adjuvants: An update on recent developments. J BioSci Biotech 2012;1:199210.
  • [43] Zhou J, Zhang Y, Wang R. Controllable loading and release of nanodrugs in polymeric vesicles. Giant 2022;12:100126. [CrossRef]
  • [44] Ye KY, Black LD 3rd. Strategies for tissue engineering cardiac constructs to affect functional repair following myocardial infarction. J Cardiovasc Transl Res 2011;4:575591. [CrossRef]
  • [45] Açarı İK, Sel E, Özcan İ, Ateş B, Köytepe S, Thakur VK. Chemistry and engineering of brush type polymers: Perspective towards tissue engineering. Adv Colloid Interface Sci 2022;305:102694. [CrossRef]
  • [46] Arif ZU, Khalid MY, Noroozi R, Sadeghianmaryan A, Jalalvand M, Hossain M. Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications. Int J Biol Macromol 2022;218:930968. [CrossRef]
  • [47] Joseph FPJ, Arun KJ, Navas A, Irene J. Biomedical applications of polymers -An overview. Curr Trends Biomed Eng Biosci 2018;15:555909. [CrossRef]
  • [48] Can N, Ersoy M. Nanofiber structured polymeric tissue scaffolds. J Text Eng 2014;21:3750. [Turkish] [CrossRef]
  • [49] Bolívar-Monsalve J, Alvarez MM, Hosseini S, Espinosa-Hernandez MA, Ceballos-González CF, Sanchez-Dominguez M, et al. Engineering bioactive synthetic polymers for biomedical applications: A review with emphasis on tissue engineering and controlled release. Mater Adv 2021;2:44474478. [CrossRef]
  • [50] Bhatt SS, Thakur G, Nune M. Preparation and characterization of PVA/Chitosan cross-linked 3D scaffolds for liver tissue engineering. Mater Today Proc 2023 Mar 1. doi: 10.1016/j.matpr.2023.02.251. [Epub ahead of print]. [CrossRef]
  • [51] Narmatha Christy P, Khaleel Basha S, Sugantha Kumari V. Multifunctional organic and inorganic hybrid bionanocomposite of chitosan/poly(vinyl alcohol)/nanobioactive glass/nanocellulose for bone tissue engineering. J Mech Behav Biomed Mater 2022;135:105427. [CrossRef]
  • [52] Faruq O, Sarkar K, Lee B. Physicochemical property and cytocompatibility of HyA-PEG loaded PMMA based bone cement. Mater Chem Phys 2022;295:127142.
  • [53] Armentano I, Dottori M, Chiralt A, Mattioli S, Kenny JM. Biodegradable polymer matrix nanocomposites for tissue engineering: A review. Polym Degrad Stab 2010;95(11):21262146. [CrossRef]
  • [54] Twaites B, de las Heras Alarcón C, Alexander C. Synthetic polymers as drugs and therapeutics. J Mater Chem 2005;15(4):441455.
  • [55] Dirauf M, Muljajew I, Weber C, Schubert US. Recent advances in degradable synthetic polymers for biomedical applications‐Beyond polyesters. Prog Polym Sci 2022;129:101547. [CrossRef]
There are 56 citations in total.

Details

Primary Language English
Subjects Clinical Chemistry
Journal Section Reviews
Authors

Fatma İrem Şahin 0000-0001-7670-8871

Nil Acaralı 0000-0003-4618-1540

Publication Date August 1, 2024
Submission Date December 29, 2022
Published in Issue Year 2024 Volume: 42 Issue: 4

Cite

Vancouver Şahin Fİ, Acaralı N. Evaluation of properties for synthetic polymers in medicine. SIGMA. 2024;42(4):1315-24.

IMPORTANT NOTE: JOURNAL SUBMISSION LINK https://eds.yildiz.edu.tr/sigma/