Parkinson Hastalarında Akupunktur Tedavisinin Etkinliğinin Değerlendirilmesi

Year 2025, Volume: 3 Issue: 3, 74 - 84, 28.12.2025

Sertaç Uslu , Özge Tuncer , İpek İnci , Nesibe Doğan , Pınar Ortan

Abstract

Amaç: Akupunktur, Parkinson Hastalığı (PH) tedavisinde en yaygın kullanılan tamamlayıcı tedavi yöntemidir. Bu çalışmada, erken evre Parkinson hastalarında akupunktur tedavisinin etkinliğini değerlendirmeyi amaçladık.
Yöntem: 29 Parkinson hastası, akupunktur (n=17) ve kontrol grubu (n=12) olmak üzere iki gruba rastgele dağıtıldı. Çalışmanın birincil sonuç ölçütü, temel alınan verilere göre 5. hafta sonunda Birleşik Parkinson Hastalığı Derecelendirme Ölçeği (UPDRS) skorlarındaki değişim idi. İkincil sonuç ölçütleri, uyku eğilimi ve yaşam kalitesini değerlendirmek için kullanılan Epworth Uykululuk Ölçeği (ESS) ve Kısa Form-36 Sağlık Durumu Anketi (SF-36) skorlarının 5 hafta sonraki değişimiydi.
Bulgular: Akupunktur grubunda, tedavi sonrasında UPDRS, ESS ve SF-36'nın fiziksel fonksiyon ve ağrı boyutu skorlarında iyileşme gözlendi (p<0,05). Akupunktur grubunda tedavi öncesi ve sonrası UPDRS-toplam ve UPDRS I-III skorlarındaki değişimin, kontrol grubuna göre istatistiksel olarak anlamlı derecede daha yüksek olduğu belirlendi (etki büyüklüğü 0,76; 0,57; 0,91; 0,94 sırasıyla, p<0,001).
Sonuç: Çalışmamız, akupunktur tedavisinin farmakolojik tedavi ile birleştirilerek semptomları ve yaşam kalitesini iyileştirmede sadece farmakolojik tedaviye göre daha etkili bir tedavi yaklaşımı olarak kullanılabileceğine dair kanıt sunmaktadır.

Keywords

Parkinson Hastalığı , Akupunktur , Birleşik Parkinson Hastalığı Derecelendirme Ölçeği , Epworth Uykululuk Ölçeği , Kısa Form 36 Sağlık Durumu Anketi

Evaluation of the Effectiveness of Acupuncture Treatment in Patients with Parkinson’s Disease

Abstract

Objectives: Acupuncture is the most widely used complementary therapy management for the treatment of Parkinson's Disease (PD). We aimed to evaluate the effectiveness of acupuncture treatment in early-stage Parkinson's patients.
Method: 29 Parkinson's patients were randomized into two groups as acupuncture (n=17) and control groups (n=12). The primary outcome measure of the study was the change from baseline to the 5th week in the Unified Parkinson’s Disease Rating Scale (UPDRS) scores. Secondary outcome measures are the change in Epworth Sleepiness Scale (ESS) and Short Form-36 (SF-36) scores, which are used to evaluate sleep propensity and quality of life, at 5 weeks.
Results: Improvement was found in the UPDRS, ESS, and SF-36 physical function and pain dimension scores after treatment in the acupuncture group (p<0.05). It was determined that the change in the UPDRS-total and UPDRSI-III scores before and after the treatment in the acupuncture group was statistically significantly higher than the control group (effect size 0.76; 0.57; 0.91; 0.94 respectively, p<0.001).
Conclusion: Our study provides evidence that combined acupuncture treatment with pharmacological treatment can be used as a more effective treatment approach in improving symptoms and quality of life than pharmacological treatment alone.

Keywords

Parkinson's disease , Acupuncture , Unified Parkinson’s Disease Rating Scale , Epworth Sleepiness Scale , Short Form 36 Health Status Questionnaire

Ethical Statement

etik kurul onayı ekte sunulmuştur

Supporting Institution

yok

References

• 1. Tysnes OB, Storstein A. Epidemiology of Parkinson’s disease. J Neural Transm 2017;124(8):901-5.
• 2. Liu J, Duan C li, Yang H. Research Progress of Pathogenesis and Treatment of Parkinsons Disease. Sheng Li Ke Xue Jin Zhan [Progress in Physiology] 2015; 46(3):163-9.
• 3. Zhao Y, Zhang Z, Qin S, Fan W, Li W, Liu J et al. Acupuncture for Parkinson’s Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit. Neural Plast. 2021: 9926445.
• 4. Zhou W, Benharash P. Effects and mechanisms of acupuncture based on the principle of meridians. J Acupunct Meridian Stud 2014; 7(4):190-3.
• 5. Xiaoping L, Wan W, Yuan W, Qiang W, Zhibin L. Global Trend in the Research and Development of Acupuncture Treatment on Parkinson's Disease From 2000 to 2021: A Bibliometric Analysis. Front Neurol 2022; 13:906317.
• 6. Sun MX, Zhang X. Effects of acupuncture for non-motor symptoms of Parkinson’s disease. J Shanghai Univ of Tradi Chin Med 2013; 27:41-8.
• 7. Akbostanci MC, Bayram E, Yilmaz V, Rzayev S, Ozkan S, Bora-Tokcaer A. et al. Turkish standardization of Movement Disorders Society Unified Parkinson's Disease Rating Scale and Unified Dyskinesia Rating Scale. Movement Disorders Clinical Practice 2018; 5(1):54-9.
• 8. Agargun M, Cilli A, Kara H, Bilici M, Telcioglu M, Semiz U, Basoglu C. Validity and Reliability of Epworth Sleepiness Scale. Turkish Journal of Psychiatry 1999; 10: 261-7.
• 9. Kocyigit H, Aydemir O, Fisek G, Olmez N, Memis AK. Reliability and validity of the Turkish version of Form-36 (SF-36). J Med Treat 1999; 12(2):102-6.
• 10. Chang XH, Zhang LZ, Li YJ. Observation on therapeutic effect of acupuncture combined with medicine on Parkinson disease. Zhongguo Zhen Jiu. 2008; 28(9):645–7.
• 11. Zhuang X, Zhuang LX. Clinical study of using tremor three needles in the treatment of Parkinson’s Disease. Clin J Tradit Chin Med. 2012; 24:1162-3.
• 12. Xu Y, Cai X, Qu S, Zhang J, Zhang Z, Yao Z et al. Madopar combined with acupuncture improves motor and non-motor symptoms in Parkinson’s disease patients: A multicenter randomized controlled trial. Eur J Integr Med. 2020; 34:101049.
• 13. Chen FP, Chang CM, Shiu JH, Chiu JH, Wu TP, Yang JL. et al. A Clinical Study of Integrating Acupuncture and Western Medicine in Treating Patients with Parkinson’s Disease. Am J Chin Med. 2015; 43(03):407-23.
• 14. Cho SY, Shim SR, Rhee HY, Cho SY, Shim SR, Rhee HY. et al. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson’s disease. Parkinsonism Relat Disord 2012; 18(8): 948-52.
• 15. Lei H, Toosizadeh N, Schwenk M, Sherman S, Karp S, Sternberg E et al. A Pilot Clinical Trial to Objectively Assess the Efficacy of Electroacupuncture on Gait in Patients with Parkinson’s Disease Using Body Worn Sensors. PLoS One. 2016;11(5): 0155613.
• 16. Noh H, Kwon S, Cho SY, Jung WS, Moon SK, Park JM. Effectiveness and safety of acupuncture in the treatment of Parkinson’s disease: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2017;34,86-103.
• 17. Liang X, Chen F. (2014) The effects of the Seven Acupoints of the Cranial Base on health-related quality of life for patients with Parkinson’s disease : a randomized controlled trial. Int J Tradit Chin Med 2014; 36:613-6.
• 18. Kluger BM, Rakowski D, Christian M, Cedar D, Wong B, Crawford J et al. Randomized, Controlled Trial of Acupuncture for Fatigue in Parkinson’s Disease. Mov Disord. 2016; 31(7): 1027-32.
• 19. Shi GX, Yang XM, Liu CZ, Wang LP. Factors contributing to therapeutic effects evaluated in acupuncture clinical trials. Trials.2012; 13(1):42.
• 20. de la Fuente-Fernández R, Ruth TJ, Sossi V, Schulzer M, Calne DB, Stoessl AJ. Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson’s Disease. Science.2001; 293(5532):1164-6.
• 21. Kong J, Gollub RL, Rosman IS, Webb JM, Vangel MG, Kirsch I, Kaptchuk TJ. Brain Activity Associated with Expectancy-Enhanced Placebo Analgesia as Measured by Functional Magnetic Resonance Imaging. J Neurosci.2006; 26 (2):381-8.
• 22. Li L, Jin X, Cong W, Du T, Zhang W. Acupuncture in the Treatment of Parkinson’s Disease with Sleep Disorders and Dose Response. Biomed Res Int, 2022,7403627.
• 23. Wang F, Sun L, Zhang XZ, Jun J, Liu Z, Huang XY et al. Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease. Evid Based Complement Alternat Med 2015,692795.
• 24. Yu SW, Lin SH, Tsai CC, Chaudhuri KR, Huang YC, Chen YS et al. Acupuncture Effect and Mechanism for Treating Pain in Patients with Parkinson’s Disease. Front Neurol. 2019;10,1114.
• 25. Lee SH, Lim S. Clinical effectiveness of acupuncture on Parkinson disease. Medicine (Baltimore). 2017;96 (3):5836.