Mikrobiyota Metaboliti: Kısa Zincirli Yağ Asitleri

Öz

Bağırsak mikrobiyotası, bakterileri, mayaları, virüsleri ve parazitleri içeren bağırsak ekosisteminin temel bileşenlerinden biri olan ve mikroplara karşı bariyer etkisi, bağışıklığın şekillenmesi ve olgunlaşması, metabolik alımın düzenlenmesi ve besinlerin emilimi de dahil olmak üzere insan sağlığında önemli bir rol oynayan ekolojik bir topluluktur. Mikrobiyotanın insan sağlığını ve hastalıklarını etkilediği mekanizmalardan biri, mikrobiyotanın ya hastalığın gelişimiyle ilişkili zararlı metabolitler ya da hastalığa karşı koruma sağlayan faydalı metabolitler üretme kapasitesidir. Mikrobiyota metaboliti olan kısa zincirli yağ asitlerinin, incelenmesindeki son gelişmeler, bunların hem hücresel hem de moleküler düzeyde çeşitli sistemler üzerindeki etkilerini ortaya çıkarmıştır. Bu çalışmanın amacı kısa zincirli yağ asitlerinin insan vücudundaki çeşitli fizyolojik işlevleri üzerine bir değerlendirme yapmaktır.

Anahtar Kelimeler

• Kısa zincirli yağ asitleri
• mikrobiyota
• bağırsak

Microbiota Metabolite: Short Chain Fatty Acids

Abstract

The gut microbiota is an ecological community that is one of the key components of the intestinal ecosystem, including bacteria, yeasts, viruses and parasites, and plays an important role in human health, including barrier action against microbes, shaping and maturation of immunity, regulation of metabolic uptake and absorption of nutrients. One of the mechanisms by which microbiota influence human health and disease is the capacity of microbiota to produce either harmful metabolites associated with the development of disease or beneficial metabolites that protect against disease. Recent advances in the study of short-chain fatty acids, a microbiota metabolite, have revealed their effects on various systems at both cellular and molecular levels. The aim of this study is to evaluate the various physiological functions of short-chain fatty acids in the human body.

Keywords

• microbiota
• gut
• Short chain fatty acids

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