Yeni Biyobelirteç Zonulin Nedir?

Abstract

İnsan bağırsağı; vücudumuzun olası dış etkenlere yönelik en büyük bariyerlerinden olmakla beraber, bu görevi intestinal epitel hücreleri arasındaki"tight junction” (sıkı bağlantı) elemanlarıyla gerçekleştirmektedir. Bu sıkı bağlantıyı oluşturan 150’nin üstünde moleküler komponent bulunmakla beraber, saptanmış tek endojen molekül zonulindir. Barsak permeabilitesinin arttığı durumda arttığı görülen zonulin molekülünün; yoğun bakteri maruziyeti, gluten enteropatisi, birçok otoimmün hastalık ve nörogelişimsel bozuklukla birlikte yükseldiği görülmüştür. Bu ve benzeri birçok hastalığın tanı ve takibinde kullanılabilecek bir molekül olduğu görülen zonulinin; gelecekteki kullanımıyla, klinik pratikte birçok hastalığın takibi için rutin izlemi değiştirebilecek bir molekül olduğu düşünülmektedir.

Keywords

• Zonulin
• Biyobelirteç
• Sıkı Bağlantı
• Otoimmünite

WHAT IS THE NEW BIOMARKER CALLED ZONULIN?

Abstract

The human intestine, one of the body’s largest barriers against potential external factors, performs this function through the tight junction elements between intestinal epithelial cells. Although more than 150 molecular components are known to form these tight connections, “zonulin” is the only identified endogenous molecule. Zonulin levels have been observed to increase in situations where intestinal permeability rises, as well as in conditions such as intense bacterial exposure, gluten enteropathy, various autoimmune diseases, and neurodevelopmental disorders. Zonulin, which appears to be a molecule that can be used in the diagnosis and monitoring of many such diseases, is considered a promising biomarker that may change the course of clinical practice in the follow-up of numerous disorders in the future.

Keywords

• Zonulin
• Biomarker
• Tight Junction
• Autoimmunity

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