Simultaneous search of multiple groups of antibiotics and their different components in the honey
Abstract
The honey is a bee (Apis mellifera) product formed by the chemical change of the nectars that the bees collect from the flowers. Honey is more or less affected by the antibiotics used in bee diseases. This contagion has vital importance in terms of public health. For this reason, simultaneous and rapid detection of different antibiotic groups in the remnants of used veterinary medications is important. Simultaneous identification of different groups of antibiotics depends on the detection method of each group, the performances of the devices, and the success of the validation. This study was carried out to realize the identification, validation and method development of the multiplex-group antibiotic residues, in the direction of EU Directive 2002/657 EEC. A different method has been developed for a total of 35 antibiotics from many groups, and the detection limits, deviations, LOD, LOQ and validations are presented. It has been identified in this study that the simultaneous detection and validation of multiplex-groups of antibiotics, which have not yet been routinely practised, is possible. With this study, a unique method and a validation technique, which may be used by national competent authorities, has been developed.
Keywords
Supporting Institution
Project Number
Thanks
References
- 1. Adams, S.J., Fussel, R.J., Dickinson, M., Wilkins, S., Sharman, M. (2009). Study of the depletion of lincomycin residues in honey Extracted from treated honeybee (Apis mellifera L.) colonies and the effect of the shook swarm procedure. Analytica chimica acta, (637): 315-320.
- 2. Adams, S.J., Henrich, K., Hetmanski, M., Fussel, R.J., Wilkins, S., Thompson, H.M., Sharman, M. (2007). Study of the depletion of tylosin residues in honey extracted from treated honeybee (Apis mellifera) colonies and the effect of the shook swarm procedure. Apidologie 38 (2007): 315-322.
- 3. Anadon, A., Arnold, D., Boobis, A.R., Ellis, R., Suarez, A.F., Friedlander, L.G., Greenlees, K., Larsen, J.C., McLean, J.G., Neto, J.P., Reeves, P., Sanders, P., Swan, G.E., Barlow, S., Bulder, A., Cerniglia, C.E., Chamberlain, P.L., Choi, M., Dunham , B., Grant, D., Imai, T., Jeong, S.H., Bizec, B.L., Lewicki, J., Ritter, L., Roberts, G., Nunez, B.S.M., Sheffer,M., Tritscher, A., Wennberg, A., Xu, S.X. (2009). Residue evaluation of certain veterinary drugs. Joint FAO/WHO expert commitee on food additives. FAO JECFA Monographs (6): 9-285.
- 4. Barganska, Z., Slebioda, M., Namiesnik, J. (2011). Determination of antibiotic residues inhoney. Trends in Analytical Chemistry, 30 (7):1035-1041.
- 5. Benetti, C., Piro,R., Binota,G., Angeletti, R., Biancotto, G. (2006). Simultaneous determination of Lincomycin and five macrolide antibiotic residues in honey by liquid chromatography coupled to electrospray ionisation mass spectrometry. Food Additives and Contaminants. 23(11): 1099-1108.
- 6. Bernal, J., Nozal, M.J., Jimenez, J.J., Martin, M.T., Sanz, E. (2009). A new and simple method to determine trace levels of sulfonamides in honey by high performance liquid chromatography with fluorescence detection. Journal of Chromatography A, 1216 (2009): 7275-7280.
- 7. Bogdanov, St. (2006): Contaminants of Bee Products. Apidologie 37 (2006). 1-18.
- 8. Bondi, M.C.M., Marazuela, M.D., Herranz, S., Rodriguez, E. (2009). An overview of sample preparation procedures for LC-MS multiclass antibiotic determination in environmental and food samples. A review. Analytical andBioanalytical Chemistry. (395):921-946.
Details
Primary Language
English
Subjects
-
Journal Section
Research Article
Authors
Namık Bilici
*
Türkiye
Yılmaz Altuner
Türkiye
Erol Kabil
Türkiye
Hatice Kübra Koç Topçuoğlu
This is me
Türkiye
Ümit Topçuoğlu
This is me
Türkiye
Publication Date
August 30, 2019
Submission Date
May 21, 2019
Acceptance Date
August 16, 2019
Published in Issue
Year 2019 Volume: 1 Number: 1