Research Article
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Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R as Pancreatic Ductal Adenocarcinoma Vaccine Candidates

Year 2023, Volume: 7 Issue: 1, 62 - 71, 15.01.2023
https://doi.org/10.33435/tcandtc.1140158

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the world's deadliest cancers. Multiple studies demonstrated that PDAC is frequently characterized by the presence of Kirsten Rat Sarcoma (KRAS) G12D, G12V, and G12R protein mutants. The mutants are potential immunotherapy targets due to their potential as cancer-specific neoantigens. KRAS G12D, G12V and G12R contain vaccine-immunogenic epitopes. KRAS G12D, G12V and G12R epitopes were presented at major histocompatibility complexes (MHC) class I. The rational design of peptide vaccines to enhance the efficacy of cancer immunotherapy is facilitated by developing a peptide structural data library and knowledge of the MHC and antigen presentation processes. Before predicting peptide activity against MHC, homology modeling must transform the peptide into a three-dimensional structure. In this study, I-TASSER was used to perform homology modeling with the assistance of other applications. In silico methods for predicting epitopes to produce rationally designed peptide vaccines can increase the efficacy of these vaccines. This study yielded four epitope models that are potential PDAC vaccination candidates, KSFEDIHHYR, GIPFIETSAK, VVVGARGVGK and VVVGADGVGK.

Supporting Institution

Research and Development Institute of Universitas Muhammadiyah Prof. DR. HAMKA

Project Number

174 / F.02.09 / 2019

Thanks

Special thanks for the assistance

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Year 2023, Volume: 7 Issue: 1, 62 - 71, 15.01.2023
https://doi.org/10.33435/tcandtc.1140158

Abstract

Project Number

174 / F.02.09 / 2019

References

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There are 61 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Research Article
Authors

Yenı Yeni 0000-0001-9042-4824

Nining Nining 0000-0003-1453-9237

Project Number 174 / F.02.09 / 2019
Early Pub Date August 15, 2022
Publication Date January 15, 2023
Submission Date July 4, 2022
Published in Issue Year 2023 Volume: 7 Issue: 1

Cite

APA Yeni, Y., & Nining, N. (2023). Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R as Pancreatic Ductal Adenocarcinoma Vaccine Candidates. Turkish Computational and Theoretical Chemistry, 7(1), 62-71. https://doi.org/10.33435/tcandtc.1140158
AMA Yeni Y, Nining N. Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R as Pancreatic Ductal Adenocarcinoma Vaccine Candidates. Turkish Comp Theo Chem (TC&TC). January 2023;7(1):62-71. doi:10.33435/tcandtc.1140158
Chicago Yeni, Yenı, and Nining Nining. “Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R As Pancreatic Ductal Adenocarcinoma Vaccine Candidates”. Turkish Computational and Theoretical Chemistry 7, no. 1 (January 2023): 62-71. https://doi.org/10.33435/tcandtc.1140158.
EndNote Yeni Y, Nining N (January 1, 2023) Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R as Pancreatic Ductal Adenocarcinoma Vaccine Candidates. Turkish Computational and Theoretical Chemistry 7 1 62–71.
IEEE Y. Yeni and N. Nining, “Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R as Pancreatic Ductal Adenocarcinoma Vaccine Candidates”, Turkish Comp Theo Chem (TC&TC), vol. 7, no. 1, pp. 62–71, 2023, doi: 10.33435/tcandtc.1140158.
ISNAD Yeni, Yenı - Nining, Nining. “Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R As Pancreatic Ductal Adenocarcinoma Vaccine Candidates”. Turkish Computational and Theoretical Chemistry 7/1 (January 2023), 62-71. https://doi.org/10.33435/tcandtc.1140158.
JAMA Yeni Y, Nining N. Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R as Pancreatic Ductal Adenocarcinoma Vaccine Candidates. Turkish Comp Theo Chem (TC&TC). 2023;7:62–71.
MLA Yeni, Yenı and Nining Nining. “Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R As Pancreatic Ductal Adenocarcinoma Vaccine Candidates”. Turkish Computational and Theoretical Chemistry, vol. 7, no. 1, 2023, pp. 62-71, doi:10.33435/tcandtc.1140158.
Vancouver Yeni Y, Nining N. Homology Modeling Epitopes of Kirsten Rat Sarcoma (KRAS) G12D, G12V and G12R as Pancreatic Ductal Adenocarcinoma Vaccine Candidates. Turkish Comp Theo Chem (TC&TC). 2023;7(1):62-71.

Journal Full Title: Turkish Computational and Theoretical Chemistry


Journal Abbreviated Title: Turkish Comp Theo Chem (TC&TC)