Abstract
Birçok ülkede, çocuklarda hipertiroidizmde ilk seçenek tedavi metimazoldür. Metimazol ile tedavi sırasında bazı yan etkiler görülebilir. Sık görülen yan etkiler döküntü, kaşıntı, artralji, bulantı ve tat değişikliğidir. Diğer ciddi yan etkileri Steven Johnson Sendromu, trombositopeni, nötropeni ve vaskülittir. Burada; metimazole bağlı vaskülit gelişen16 yaşındaki kız hastayı tartışacağız. Hastamızda metimazole bağlı vaskülit tedaviden sonraki birinci ayda görülmüştür. Vaskülit semptomları tedavi kesiminden sonra hızlıca kaybolmuştur. Vaskülit metimazolün ağır bir yan etkisidir ve tedavi kesilmesini gerekmektedir.
Keywords
References
- A Fava, R Oliverio, S Giuliano, G Parlato, A Michniewicz, A Indrieri, et al. Clinical evolution of autoimmune thyroiditis in children and adolescents. Thyroid 2009;19:361-7.
- Nabhan ZM, Kreher NC, Eugster EA. Hashitoxicosis in children: Clinical features and natural history. J Pediatri 2005;146:533–6.
- Wasniewska M, Corrias A, Salerno M, Lombardo F, Aversa T, Mussa A. Outcomes of children with hashitoxicosis. Horm Res Paediatr 2012;77:36–40.
- Burch HB, Burman KD, Cooper DS. A 2011 survey of clinical practice patterns in the management of Graves’ disease. J Clin Endocrinol Metab 2012;97:4549–58.
- Cooper DS. Antithyroid drugs. N Engl J Med 2005;352:905–17.
- Bahn Chair RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, et al; American Thyroid Association; American Association of Clinical Endocrinologists. Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid 2011;21:593–646.
Abstract
Methimazole therapy is the first-line treatment in children with hyperthyroidism in many countries. Treatment with methimazole may be accompanied by side effects. Common side effects include rash, pruritus, arthralgia, nausea, and reduced taste. Other serious side effects include the Stevens-Johnson Syndrome, thrombocytopenia, neutropenia, and vasculitis. Here, we report a 16-year-old girl with methimazole-induced vasculitis. The onset of vasculitis in our patient was one month after the initiation of methimazole therapy. The symptoms of vasculitis disappeared rapidly following cessation of treatment. Vasculitis is a serious side effect of methimazole and is an indication for prompt cessation of treatment
Keywords
References
- A Fava, R Oliverio, S Giuliano, G Parlato, A Michniewicz, A Indrieri, et al. Clinical evolution of autoimmune thyroiditis in children and adolescents. Thyroid 2009;19:361-7.
- Nabhan ZM, Kreher NC, Eugster EA. Hashitoxicosis in children: Clinical features and natural history. J Pediatri 2005;146:533–6.
- Wasniewska M, Corrias A, Salerno M, Lombardo F, Aversa T, Mussa A. Outcomes of children with hashitoxicosis. Horm Res Paediatr 2012;77:36–40.
- Burch HB, Burman KD, Cooper DS. A 2011 survey of clinical practice patterns in the management of Graves’ disease. J Clin Endocrinol Metab 2012;97:4549–58.
- Cooper DS. Antithyroid drugs. N Engl J Med 2005;352:905–17.
- Bahn Chair RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, et al; American Thyroid Association; American Association of Clinical Endocrinologists. Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid 2011;21:593–646.
Details
| Other ID | JA36NE55VN |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | April 1, 2018 |
| Submission Date | April 1, 2018 |
| Published in Issue | Year 2018 Volume: 12 Issue: 1 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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