Abstract
Konjenital toksoplazmozis gebelikte geçirilen akut enfeksiyonun fetusa geçmesiyle oluşan ve nadir görülen bir enfeksiyondur. Hastalık, yenidoğanlarda serolojik olarak saptanan hafif formdan, koryoretinit, menenjit, hidrosefali ve intrakraniyal kalsifikasyonlar gösteren ağır forma kadar geniş bir spektrum içinde kendini gösterebilir. Gebeliğin erken dönemlerinde enfeksiyonun bebeğe geçme riski düşükken, enfeksiyonun ağırlığı ve sekelleri daha ciddidir. Enfeksiyonun tanısı parazitin kendisinin, DNA parçalarının veya parazitin yüzey antijenlerine karşı oluşmuş antikorların gösterilmesi esasına dayanmaktadır. Makalede erken dönem gebelik takipleri düzenli olmayan iki konjenital toksoplazmozis olgusu sunulmaktadır. İlk olgunun ailesi Suriye’den savaş nedeniyle göç etmiş ve göç sonrası yaşam koşullarının zor olması nedeniyle gebelik takipleri düzenli yapılmamıştı. İkinci olguda da annenin 4. gebeliği olmasına rağmen gebelik takiplerinin düzenli yapılmadığı dikkati çekti.Sonuç olarak konjenital toksoplazmozis sinsi ve fatal seyirli bir hastalıktır. Gebelikte ya da erken dönemde tedaviye başlanması prognozu olumlu yönde etkilemektedir. Hastalığın erken tanısını için gebelik takiplerinin düzenli yapılması gerekmektedir. Bu konuda gerek mülteciler gerekse yerli halkın yeterli düzeyde bilinçlendirilmeli ve yetkili birimlerin gerekli önlemleri alması gerektiğine ayrıca dikkat çekmek istedik.
Keywords
References
- Carter AO, Frank JW. Congenital toxoplasmosis: Epidemiologic features and control. CMAJ 1986;135: 618–23.
- Uludağ S, Madazlı R, Sen C, Ocak V. Gebelik ve toksoplazmozisde klinik yönetim. Perinatoloji Dergisi 1993;1:165-9.
- Desmonts G, Couvreur J. Congenital toxoplasmosis. Prospective study of the outcome of pregnancy in 542 women with toxoplasmosis acquired during pregnancy. Ann Pediatr (Paris) 1984;31:805-9.
- Mandell GL, Benett JE, Dolin R. Principles and practice of infectious diseases. In: Montoya JG, Kovacs JA, Remington JS (eds). Toxoplasma Gondii. 6th ed. Newyork: Churchill Livingstone, 2005;2:3170-228.
- Magi B, Migliorini L. Western blotting for the diagnosis of congenital toxoplasmosis. New Microbiol 2011;34:93-5.
- Remington JS, McLeod R, Wilson CB, Desmonts G. Toxoplas- mosis. In: Remington, JS, Klein, JO, Wilson, CB (eds). Infectious Diseases of the Fetus and Newborn Infant, 7th ed. Philadelphia: Elsevier Saunders, 2011:918.
Abstract
Congenital toxoplasmosis is a rare intrauterine infection caused by acute infection of the mother during pregnancy. Congenital toxoplasmosis can present in a spectrum from a mild form to a severe form including chorioretinitis, meningitis, hydrocephaly and intracranial calcification. Although possibility of passage to the fetus is low in early pregnancy, the severity and sequela risk are high. Diagnosis depends on the demonstration of the parasites itself, its DNA extracts, or antibodies against the surface antigens of the parasites. Here we present two cases of congenital toxoplasmosis that did not have antenatal follow-up. The family of the first case arrived from Syria due to war and the mother did not receive any antenatal care because of poor living conditions after the forced migration. The second case was the fourth pregnancy of the mother who did not have any antenatal care.Finally, congenital toxoplasmosis is an insidious and fatal disease. Early treatment during pregnancy or the postnatal period has positive effects on the prognosis. Antenatal care is important in the diagnosis. We would like to underline the importance of informing both refugees and natives about antenatal care and the necessity of taking preventive measures for refugees by the authorities
Keywords
References
- Carter AO, Frank JW. Congenital toxoplasmosis: Epidemiologic features and control. CMAJ 1986;135: 618–23.
- Uludağ S, Madazlı R, Sen C, Ocak V. Gebelik ve toksoplazmozisde klinik yönetim. Perinatoloji Dergisi 1993;1:165-9.
- Desmonts G, Couvreur J. Congenital toxoplasmosis. Prospective study of the outcome of pregnancy in 542 women with toxoplasmosis acquired during pregnancy. Ann Pediatr (Paris) 1984;31:805-9.
- Mandell GL, Benett JE, Dolin R. Principles and practice of infectious diseases. In: Montoya JG, Kovacs JA, Remington JS (eds). Toxoplasma Gondii. 6th ed. Newyork: Churchill Livingstone, 2005;2:3170-228.
- Magi B, Migliorini L. Western blotting for the diagnosis of congenital toxoplasmosis. New Microbiol 2011;34:93-5.
- Remington JS, McLeod R, Wilson CB, Desmonts G. Toxoplas- mosis. In: Remington, JS, Klein, JO, Wilson, CB (eds). Infectious Diseases of the Fetus and Newborn Infant, 7th ed. Philadelphia: Elsevier Saunders, 2011:918.
Details
| Other ID | JA46TT99KP |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | June 1, 2017 |
| Submission Date | June 1, 2017 |
| Published in Issue | Year 2017 Volume: 11 Issue: 2 |
The publication language of Turkish Journal of Pediatric Disease is English.
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