Abstract
Amaç: Henoch-Schönlein Purpurası (HSP) olan çocuk hastalarda Helikobakter Pilori (HP) enfeksiyonunun sıklığının araştırılması amaçlanmıştır.Gereç ve Yöntemler: Haziran 2009 - Aralık 2011 tarihleri arasında HSP tanısı alan 61 hasta ve benzer yaşlarda 62 sağlıklı çocuktan oluşan kontrol grubunda ELISA yöntemi ile HP IgG ve IgA serolojisi çalışıldı.Bulgular: HSP’li 61 hastanın (yaş ort: 8.53±3.8 yıl, K/E: 32/29) 34’ünde (%55.7) HP IgG, 37’sinde (%60.6) HP IgA tipi antikor varlığı saptandı. Kontrol grubunda (yaş ort: 9.16±3.3 yıl, K/E: 30/32) HP IgG antikor pozitifliği %61.3 saptandı. Hasta ve kontrol grupları arasında HP IgG pozitifliği açısından istatistiksel anlamlı bir fark yoktu. Karın ağrısı olanlarda HP IgG pozitifliği %64.5, IgA pozitifliği %71 idi. Mide ağrısı (epigastik ağrı) tarif edenlerde HP IgG pozitifliği %60’dı. HP IgG pozitifliği ile GİS bulgularının şiddeti arasında istatistiksel olarak anlamlı bir fark saptanmadı.Sonuç: Sonuç olarak sağlıklı çocuklarda bile %60’lara varan HP seropozitivitesinin görülmesi, toplumumuzda HP ile erken yaşta karşılaşmanın iyi bir göstergesidir. Bu enfeksiyonun gastrointestinal yakınmalar dışında da birçok hastalığa neden olabileceği düşünüldüğünde çok önemli bir toplum sağlığı sorunu olduğu açıktır. HSP’li hastalarda HP seropozitivitesi yüksek bulunmakla beraber sağlıklı çocuklardan farklı bulunmamıştır.
References
- Yang YH, Yu HH, Chiang BL. The diagnosis and classifi cation of Henoch-Schönlein purpura: An updated review. Autoimmun Rev 2014;13:355-8.
- Ebert EC. Manifestation of Henoch-Schonlein purpura. Dig Dis Sci 2008; 53: 2011-2019.
- Zhang Y, Huang X. Gastrointestinal involment in Henoch-Schönlein purpura. Scand J Gastroenterol 2008; 43:1038-43.
- Rigante D, Castellazzi L, Bosco A, Esposito S. Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura? Autoimmun Rev 2013;12: 1016-21.
Abstract
Objective: We investigated the frequency of Helicobacter Pylori (HP) infection in children with Henoch-Schönlein purpura (HSP).Material and Methods: The study involved 61 patients with HSP and 62 healthy controls of similar age between July 2009 and December 2011. HP IgG and IgA levels were evaluated by the ELISA method in all patients and controls. Results: The HP IgG and IgA seropositivity rates were 55.7% and 60.6% in HSP patients (mean age 8.53±3.8 years, F/M: 32/29) and HP IgG seropositivity was 61.3% in normal controls (mean 9.1±3.3 years, F/M: 30/32). There was no statistical difference between the two groups. The HP IgG seropositivity rate was 64.5% in patients with abdominal pain and 60% in those with epigastric pain. There was no signifi cant relationship between HP seropositivity and the degree of abdominal complaints. Conclusion: HP seropositivity was found in up to 60% percent of healthy control subjects, indicating that HP infection begins in early childhood. It is an important public health problem as it can cause many other disorders in addition to its effects on the gastrointestinal system. The HP seropositivity rate was high in HSP patients but not different from healthy controls
References
- Yang YH, Yu HH, Chiang BL. The diagnosis and classifi cation of Henoch-Schönlein purpura: An updated review. Autoimmun Rev 2014;13:355-8.
- Ebert EC. Manifestation of Henoch-Schonlein purpura. Dig Dis Sci 2008; 53: 2011-2019.
- Zhang Y, Huang X. Gastrointestinal involment in Henoch-Schönlein purpura. Scand J Gastroenterol 2008; 43:1038-43.
- Rigante D, Castellazzi L, Bosco A, Esposito S. Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura? Autoimmun Rev 2013;12: 1016-21.
Details
| Other ID | JA82RV85ER |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | April 1, 2016 |
| Submission Date | April 1, 2016 |
| Published in Issue | Year 2016 Volume: 10 Issue: 1 |
The publication language of Turkish Journal of Pediatric Disease is English.
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