Research Article
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Morphological and Mechanical Assessment of Electrospun PLGA Vascular Scaffolds

Year 2024, Volume: 34 Issue: 3, 222 - 230, 30.09.2024
https://doi.org/10.32710/tekstilvekonfeksiyon.1284898

Abstract

Cardiovascular disorders are the leading cause of global mortality and typically necessitate bypass surgery to replace the damaged blood vessel. Currently used grafts are insufficient to replace small-diameter blood vessels due to the scarcity and harsh harvesting procedure of autologous vessels and the shortcomings in the clinical performance of synthetic grafts, which might result in intimal hyperplasia, thrombosis, and compliance mismatch. Therefore, there is a critical need for tissue-engineered vascular grafts that can meet morphological, mechanical, and biological characteristics. In this study, poly(lactic-co-glycolic acid) tubular scaffolds with randomly distributed or radially oriented fibers were produced by electrospinning, and the effect of fiber orientation on morphological and mechanical properties was investigated. The findings demonstrate that, while the successful implementation of radial fiber orientation with high rotational speed production enhanced burst strength and radial tensile strength values, it was unfavorable for compliance.

Supporting Institution

TUBITAK , ITU

Project Number

121M309 (TUBITAK), 43368 (ITU-BAP), 44230 (ITU-GAP)

Thanks

This study is supported by TUBITAK Project under grant no. 121M309, ITU Scientific Research Project under grant no. 43368, and ITU General Research Project under grant no. 44230.

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Year 2024, Volume: 34 Issue: 3, 222 - 230, 30.09.2024
https://doi.org/10.32710/tekstilvekonfeksiyon.1284898

Abstract

Project Number

121M309 (TUBITAK), 43368 (ITU-BAP), 44230 (ITU-GAP)

References

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  • 2. Awad, N. K., Niu, H., Ali, U., Morsi, Y. S., & Lin, T. (2018). Electrospun fibrous scaffolds for small-diameter blood vessels: A review. Membranes 8(1) https://doi.org/10.3390/membranes8010015
  • 3. Ravi, S., & Chaikof, E. L. (2010). Biomaterials for vascular tissue engineering. In Regenerative Medicine (Vol. 5, Issue 1, pp. 107–120). https://doi.org/10.2217/rme.09.77
  • 4. Carrabba, M., & Madeddu, P. (2018). Current strategies for the manufacture of small size tissue engineering vascular grafts. In Frontiers in Bioengineering and Biotechnology (Vol. 6, Issue APR). Frontiers Media S.A. https://doi.org/10.3389/fbioe.2018.00041
  • 5. Teebken, O. E., & Haverich, A. (2002). Tissue Engineering of Small Diameter Vascular Grafts. http://www.idealibrary.com
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  • 8. Safak, S., Vatan, O., Cinkilic, N., & Karaca, E. (2020). In vitro evaluation of electrospun polysaccharide based nanofibrous mats as surgical adhesion barriers. Tekstil ve Konfeksiyon, 30(2), 99–107. https://doi.org/10.32710/tekstilvekonfeksiyon.548460
  • 9. Chen, Y., Dong, X., Shafiq, M., Myles, G., Radacsi, N., & Mo, X. (2022). Recent Advancements on Three-Dimensional Electrospun Nanofiber Scaffolds for Tissue Engineering. In Advanced Fiber Materials (Vol. 4, Issue 5, pp. 959–986). Springer. https://doi.org/10.1007/s42765-022-00170-7
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Details

Primary Language English
Subjects Wearable Materials
Journal Section Articles
Authors

Suzan Özdemir 0000-0001-7369-2907

Janset Öztemur 0000-0002-7727-9172

Hande Sezgin 0000-0002-2671-2175

İpek Yalcin Enis 0000-0002-7215-3546

Project Number 121M309 (TUBITAK), 43368 (ITU-BAP), 44230 (ITU-GAP)
Early Pub Date September 30, 2024
Publication Date September 30, 2024
Submission Date April 19, 2023
Acceptance Date November 9, 2023
Published in Issue Year 2024 Volume: 34 Issue: 3

Cite

APA Özdemir, S., Öztemur, J., Sezgin, H., Yalcin Enis, İ. (2024). Morphological and Mechanical Assessment of Electrospun PLGA Vascular Scaffolds. Textile and Apparel, 34(3), 222-230. https://doi.org/10.32710/tekstilvekonfeksiyon.1284898

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