The histopathologic features of 172 meningioma cases

Abstract

Aim: We aimed to evaluate the incidence and the clinicopathological aspects of meningiomas in our region which had been diagnosed in our laboratory in the last 10 years . Materials and methods: The 172 cases which had been diagnosed as meningioma in Göztepe SSKB Educational Hospital Pathology Laboratory during the period of 19932003 have been reevaluated with respect to their clinical and histopathological features using the 2000 WHO (World Health Organization) classification. Results: Meningiomas comprise the %19,7 of 782 intracranial tumors. 154 of the 172 meningioma cases are located intracranially whereas the 18 are located intraspinally (%10,48). They are frequently located at the parasagital region and at the convexity. Meningioma incidence in females is 2,8 times higher than males. The age range is 2-76, and mean age is 51. %89 of the cases is Grade I, whereas %11 is Grade II. 8 of the cases have recurred. Among these cases only 3 are Grade II. Transitional type (%38,1) is the most common type followed by meningotheliomatous (%23,8), psammomatous (%10,7), atypical (%8,9), fibrous (%8,3), microcystic (%3,6), angiomatous (%2,4), clear cell (%2,4), metaplastic (%1,2) and secretory types (%0,6). Conclusion: Meningiomas are frequently encountered tumors with a wide histological spectrum. Atypia and malignancy criteria have been re-defined and new subtypes have been established. In this respect, the diagnoses are subject to change if the cases are retrospectively analyzed

Keywords

• Epidemiology, meningioma, brain tumor, histological subtypes

172 meningiom olgusunun histopatolojik özellikleri

Öz

Amaç: Amacımız laboratuarımızda son 10 yılda (19932003) meningiom tanısı almış olguların klinikopatolojik özelliklerini ve bölgemizdeki sıklığını araştırmaktır. Gereç ve yöntem: Göztepe SSKB Eğitim Hastanesi Patoloji Laboratuarında 1993-2003 yılları arasında meningiom tanısı alan 172 olgu, 2000 DSÖ (Dünya Sağlık Örgütü) sınıflamasına göre histopatolojik olarak, klinikopatolojik özellikleri ile birlikte yeniden değerlendirildi. Bulgular: Toplam 172 meningiom olgusu 782 intrakranial tümörün %19,7’sini oluşturmuştur. Bunların %89,5 (154 olgu)’i kranial, %10,48 (18 olgu)’i ise spinal yerleşimlidir. Sıklıkla parasagital bölge ve konveksitede yerleşimlidirler. Kadınlarda erkeklerden 2,8 kat daha çoktur. Görülme yaş aralığı 2-76, ortalama yaş ise 51’dir. Olguların %89’u Derece I, %11’i ise Derece II dir. Olgulardan 8’i nüks etmiştir. Bu olgulardan yalnızca 3’ü Derece II’dir. Histopatolojik olarak en sık transizyonel tür (%38,1) ve bunu izleyen meningotelyomatöz (%23,8), psammomatöz (%10,7), atipik (%8,9), fibröz (%8,3), mikrokistik (%3,6), anjiomatöz ve saydam hücreli türler (%2,4), metaplastik (%1,2) ve sekretuar meningioma türleri (%0,6) görülmüştür. Sonuç: Sonuç olarak, meningiomlar kadınlarda daha sıktır ve büyük oranda morfolojik olarak benign özellikte tipik meningioma olarak izlenir. Atipi ve malignite kriterleri geçmişten günümüze değişmiş ve yeni alt türler tanımlanmıştır. Bu nedenle geriye dönüldüğünde olgular farklı tanı alabilmektedirler

Anahtar Kelimeler

• Epidemiyoloji, meningiom, beyin tümörü, histolojik alt türler

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