Viral infections on renal allograft biopsies

Year 2003, Volume: 9 Issue: 3-4, 109 - 117, 01.11.2003

S. Şen B. Arda E. Ok

Abstract

Keywords

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Transplant böbrek biopsilerinde viral enfeksiyonlar

Abstract

Allograft böbreklerdeki immunolojik hasarın daha etkili immunsüpressif sağaltım ile önlenmesi, viral enfeksiyöz komplikasyonları artırma eğilimi nedeniyle iki ucu keskin bıçak gibidir. Transplantasyon sonrası mortalite ve morbiditeyi anlamlı olarak etkileyen bu enfeksiyonların spektrumları son yıllarda değişmiştir. Allograft böbrekte fonksiyon bozukluğu geliştiğinde, hastayı potansiyel ciddi komplikasyonlardan korumak için tanı ve sağaltımın en uygun biçimde yapılması gerekir. Bu derleme böbrek transplantasyon alıcılarındaki bazı viral enfeksiyonların histopatolojik bulguları ve genel özellikleri üzerinde odaklanmıştır

Keywords

Viral enfeksiyon, Polyoma virüs, sitomegalovirüs, interstisyel nefrit, böbrek tranplantasyonu

References

• Colvin RB. Renal transplant pathology. Jennette JC, Olson JL, Schwartz MM, Silva FG, eds. Heptinstalls Pathology of the Kidney. 5. baskı. Philadelphia: Litlle Brown, 1998: 1409-1540.
• Smith SR, Butterly DW, Alexander BD, Greenberg A. Viral infections after renal transplantation. Am J Kidney Dis 2001; 37: 659-676.
• Colvin RB, Fang LST. Interstitial Nephritis. Tisher CC, Brenner BM, eds. Renal Pathology, with Clinical and Functional Correlations. 2. baskı. Philadelphia: JB Lippincott, 1994; 723-768.
• Classen DC, Flinner RL. Infections in Transplant Patients. Hammond E, Ed. Solid Organ Transplantation Pathology. Saunders WB, Philadelphia 1994; 239-261.
• Nickeleit V. Renal Allograft Viral Infections: How Important are They? http://www.hdcn.com/symp/00asn/nick/nick2.htm (accessed on September 2001).
• Shah KV. Human Polyomavirus BKV and renal disease. Nephrol Dial Transplant 2000; 15: 754-755.
• Randhawa PS, Finkelstein S, Scantlebury V et al. Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 1999; 67: 103-109
• Howell DN, Smith SR, Butterly DW, et al. Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients. Transplantation 1999; 68: 1279- 1288.
• Drachenberg CB, Beskow CO, Cangro CB, et al. Human polyoma virus in renal allograft biyopsies: morphological findings and correlation with urine cytology. Human Pathol 1999; 30: 970-977.
• Binet I, Nickeleit V, Hirsch HH et al. Polyomavirus disease under new immunosuppressive drugs: a cause of renal graft dysfunction and graft loss. Transplantation 1999; 67: 918–922.
• Nickeleit V, Hirsch HH, Zeiler M, et al. BK-virus nephropathy in renal transplants: Tubular necrosis, MHC- class II expression and rejection in a puzzling game. Nephrol Dial Transplant 2000; 15: 324-332.
• Ahuja M, Cohen EP, Dayer AM, et al. Polyoma virus infection after renal transplantation. Use of immunostaining as a guide to diagnosis. Transplantation 2001; 71: 896-899.
• Randhawa PS, Demetris AJ. Nephropathy due to polyomavirus type BK. N Engl J Med 2000, 342: 1361- 1363.
• Mayr M, Nickeleit V, Hirsch HH, et al. Polyomavirus BK nephropathy in a kidney transplant recipient: critical issues of diagnosis and management. Am J Kidney Dis 2001; 38: E13.
• Nickeleit V, Hirsch HH, Binet IF et al. Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease. J Am Soc Nephrol 1999; 10: 1080-1089.
• Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 2002; 347: 488-496.
• Fishman JA. BK virus nephropathy Polyomavirus adding insult to injury N Engl J Med 2002; 347: 527-530.
• Petrogiannis-Haliotis T, Sakoulas G, Kirby J, et al. BK- related polyomavirus vasculopathy in a renal-transplant recipient. N Engl J Med 2001; 345: 1250-1255.
• Şen S, Duman S, Zekioğlu O, ve ark. Renal transplant- tasyon olgusunda viral tübülo interstisyel nefrit (olgu sunumu). Türk Nef Dializ ve Transpl Derg 2002; 11: 178- 182.
• Brennan DC. Cytomegalovirus in renal transplantation. J Am Soc Nephrol 2001; 12: 848-855.
• Rubin RH, Colvin RB. Impact of Cytomegalovirus Infection on Renal Transplantation. In: Racusen L, Solez K, Burdick JF (Eds), Kidney Transplant Rejection: Diagnosis and Treat- ment. 3. baskı. New York: Dekker Marcel, 1998; 605-625.
• Dickenmann MJ, Cathomas G, Steiger J, et al. Cytome- galovirus infection and graft rejection in renal transplant- tation. Transplantation 2001; 71: 764-767.
• Kashyap R, Shapiro R, Jordan M, Randhawa PS. The clinical significance of cytomegaloviral inclusions in the allograft kidney. Transplantation 1999; 67: 98-103.
• Shaver MJ, Bonsib SM, Abul-Ezz S, Barri YM. Renal allograft dysfunction associated with cytomegalovirus infection. Am J Kidney Dis 1999; 34: 942-946.
• Waiser J, Budde K, Rudolph B, et al. De novo hemolytic uremic syndrome postrenal transplant after cytomegalo- virus infection. Am J Kidney Dis 1999; 34: 556-559.
• Herrera GA, Alexander RW, Cooley CF, et al. Cytomegalo- virus glomerulopathy: a controversial lesion. Kidney Int 1986; 29: 725-733.
• Platt JL, Sibley RK, Michael AF. Interstitial nephritis asso- ciated with cytomegalovirus infection. Kidney Int 1985; 28: 550-552.
• Patra S, Samal SC, Chacko A, et al. Cytomegalovirus infection of the human gastrointestinal tract. J Gastroen- terol Hepatol 1999; 14: 973-976.
• Şen S, Duman S,Sarsık B, ve ark. Cytomegalovirus infection in the renal allograft biopsy.Annals of Saudi Medicine, 2003; 23: 306-311.
• Randhawa P, Demetris AJ, Pietrzak B, Nalesnik M. Histopathology of renal posttransplant lymphoproliferation: comparison with rejection using the Banff schema. Am J Kidney Dis 1996; 28: 578-584.
• Randhawa PS, Magnone M, Jordan M, et al. Renal allograft involvement by Epstein-Barr virus associated post- transplant lymphoproliferative disease. Am J Surg Pathol. 1996; 20: 563-571.
• Trpkov K, Marcussen N, Rayner D, et al. Kidney allograft with a lymphocytic infiltrate: acute rejection, posttrans- plantation lymphoproliferative disorder, neither, or both entities? Am J Kidney Dis 1997; 30: 449-454.
• Şen S, Hekimgil M, Duman S, et al. Böbrek trans- plantasyonu yapılmış iki olguda post transplant lenfo- proliferatif hastalık. Türk Nefrol Dializ ve Transpl Derg 2000; 8: 54-57.
• Gentile G. Post-transplant HHV-6 Diseases. Herpes 2000; 7: 24-27.
• Markowitz GS, Williams GS, Chang Y, et al. A novel etiology of renal allograft dysfunction. Am J Kidney Dis 2001; 38: 658-663.
• Ito M, Hirabayashi N, Yutaka U, Nakayama A, Asai J. Necrotizing tubulointerstitial nephritis associated with adenovirus infection. Hum Path 1991; 22: 1225-1231.
• Mathur SC, Squiers EC, Tatum AH, et al. Adenovirus infection of the renal allograft with sparing of pancreas graft function in the recipient of a combined kidney-pancreas transplant. Transplantation 1998; 65: 138-141.
• Asim M, Chong-Lopez A, Nickeleit V. Adenovirus infection of a renal allograft. Am J Kidney Dis 2003; 41: 696-701.
• Landry ML, Fong CKY, Nedderman K, et al. Disseminated adenovirus infection in an immunocompromised host. Am J Med 1987; 83: 555-559.
• Roth, D, Cirocco, R, Zucker, K, et al. De novo mem- branoproliferative glomerulonephritis in hepatitis C virus- infected renal allograft recipients. Transplantation 1995; 59: 1676-1578.
• Cruzado JM, Gil-Vernet S, Ercilla G, et al. Hepatitis C virus- associated membranoproliferative glomerulonephritis in renal allografts. J Am Soc Nephrol 1996; 7: 2469-2475
• Cruzado JM, Torras J, Gil-Vernet S, Grinyo JM. Glome- rulonephritis associated with hepatitis C virus infection after renal transplantation. Nephrol Dial Transplant 2000;15 Suppl 8:65-67.
• D'Amico G. Renal involvement in hepatitis C infection: cryoglobulinemic glomerulonephritis. Kidney Int 1998; 54: 650-671.
• Baid S, Cosimi AB, Tolkoff-Rubin N, et al. Renal disease associated with hepatitis C infection after kidney and liver transplantation. Transplantation 2000; 70: 255-261.
• Baid S, Pascual M, Williams WW, et al. Renal thrombotic microangiopathy associated with anticardiolipin antibodies in hepatitis C-positive renal allograft recipients. J Am Soc Nephrol 1999; 10:146-153.
• Cosio FG, Roche Z, Agarwal A, et al. Prevalence of hepatitis C in patients with idiopathic glomerulopathies in native and transplant kidneys. Am J Kidney Dis 1996; 28:752-758.
• Şen S, Töz H, Duman S, Başdemir G. Impact of hepatitis C virus infection on histopathological findings of chronic renal allograft nephropathy. J Am Soc Nephrol 2001;12: 917A.
• Berthoux P, Laurent B, Cecillon S, Berthoux F. Membrano- proliferative glomerulonephritis with subendothelial depo- sits (type 1) associated with hepatitis G virus infection in a renal transplant recipient. Am J Nephrol 1999; 19: 513-518.
• Moudgil A, Shidban H, Nast CC, et al. Parvovirus B19 infection-related complications in renal transplant reci- pients: treatment with intravenous immunoglobulin. Trans- plantation 1997; 64: 1847-1850.
• Vilchez RA, McCurry K, Dauber J, et al. Influenza virus infection in adult solid organ transplant recipients. Am J Transplant 2002; 2: 287-289.