Ratlarda Oral Olarak Verilen Linear Alkil Benzen Sülfonatın Las Serum Ve Karaciğerdeki Üre, Glukoz Ve Total Bilirubin Düzeyleri Üzerine Kronik Etkilerinin Araştırılması

Year 2001, Volume: 58 Issue: 2, 39 - 48, 01.06.2001

Meryem Şakar Ahmet Mengi

https://izlik.org/JA84MF54FA

Abstract

Bu araştırmada ratlara oral olarak verilen Linear Alkil Benzen Sülfonat LAS ’ın serum ve karaciğerdeki glukoz, total bilirubin ve üre düzeyleri üzerine kronik etkileri incelenmiştir. Bu çalışmada LAS’ın %0.002 0.14mg/kg ’lık ve %0.005 0.35mg/kg ’lık dozlarının ratlarda kronik olarak herhangi bir toksisiteye neden olmayacağı ve ratlar için LAS’ın kronik etkilerinin %0.01 0.7mg/kg ile %0.03 2.1mg/kg dozlarında ve 120.günden itibaren gerçekleştiği sonucuna varılmıştır.

Keywords

Linear Alkil Benzen Sülfonat , Glukoz , Total Bilirubin , Üre

Chronic Effects Of Linear Alkyl Benzene Sulphonate Las Given By Oral Route On The Levels Of Glucose, Total Bilirubine And Urea In Serum And Liver Of Rats

https://izlik.org/JA84MF54FA

Abstract

In this study, ıt was examined the chronic effects of Linear Alkyl Benzene Sulphonate LAS given by oral route, on the levels of glucose, total bilirubine and urea in serum and liver of rats. It was concluded that LAS in doses of 0.002 % 0.14 mg/kg and 0.005 % 0.35 mg/kg may be unimportant in rats because it created non-toxic chronic effects and chronic toxicologic effects of LAS for rats occur in doses of 0.01 % 0.7 mg/kg and 0.03 % 2.1 mg/kg and 120. days after the application.

Keywords

Linear Alkyl Benzene Sulphonate , Glucose , Total Bilirubine , Urea

References

• 1. Anonim. TUBİTAK Tıp Araştırma Grubu. Deterjanların İnsan Sağlığı Üzerine Etkileri İhtisas Komisyonu Toplantı Raporu 1987; 1-14.
• 2. Anonim: The panel for negative effects of detergents to environmental water resources and the health of human. Erler Matb İstanbul 1986; 5-61.
• 3. Kumbur H. Sentetik deterjanlar ve yarattıkları çevre sorunları. G Ü Müh Mim Fak 1988; 14-21.
• 4. Lewis MA. Chronic and sublethal toxicities of surfactants to aquatic animals: a review and risk assesment. Wat Res 1991; 25 (1): 101-13.
• 5. Field AJ, Miller DJ, Field TM, Hawthorne SB, Giger W. Quantitaive determination of sulfonated aliphatic surfactants in sewage sludge by ion pair/supercritical fluid extraction and derivatization gas chromatography/mass spectrometry Anal Chem 1992; 64: 3161-7.
• 6. Sigoillot JC, Nguyen M H. Complete oxidation of linear alkylbenzene sulfonate by bacterial communities selected from coastal seawater. Appl Environ Microbiol 1992; 10: 1308-12.
• 7. Özcan A, Mengi A. Ratlarda oral olarak verilen alkolün serum, karaciğer ve böbrekteki gama- GT, ALT ve AST düzeyleri ile karaciğer yağlanması üzerine etkileri. J Vet Animal Sci 1998; 20: 181-5.
• 8. Perk M, Mengi A. Sığırlarda karaciğer hücreleri ile serumda GOT, GPT enzimlerinin saptanması. İstanbul Üniv Vet Fak Derg 1993; 19 (2): 133-8.
• 9. Şener S. Etanolün kobayda karaciğer ve serum gamma glutamil transferaz (GGT) aktivitesi üzerine etkisi. İstanbul Üniv. Vet. Fak. Derg. 1988; (14) 2: 1-10.
• 10. Sümbüloğlu KV. Biyoistatistik Hacettepe Ünv. Tıp Fak 1989; 12.
• 11. Agarwal C, Mathur AK, Gupta BN, Singh A, Shanker R. Synthetic detergents induced biochemical and histological changes in skin of guinea pigs. İndusexperimental Toxicol Res Centre 1990; 36; 316-8.
• 12. Bielinska T. Dielectric, haematological and biochemical studies of detergent toxicity in fish blood. Phys Med Biol 1987; 32 (5): 623-35.
• 13. Buehler EV, Newmann EA, King R. Two – year feeding and reproduction study in rats with linear alkylbenzene sulfonate (las). Toxicol Appl Pharmacol 1971; 18: 83-91.
• 14. Daily LW, Schroeder RE. A teratology study of topically applied linear alkylbenzene sulfonate in rats Fd Cosmet Toxicol 1980; 18: 55-8.
• 15. Hwang DE, Chen MY, Yoshida T, Jeng SS. Toxic effects of linear alkylbenzene sulfonate on the tiger prawn penaeus monodon. Ecotoxicol Environ 1993; 26: 285-92.
• 16. Ros DI, Nasci CG, Campesan P, Sartorelle P, Stocco G, Menetto, A. Effects of linear alkylbenzene sulphonate (las) and cadmium in the digestive gland of mussel, mytilus sp. Marine Environ Res 1995; 39: 321-4.
• 17. Froebe CL, Simon FA, Rhein LD, Cagan RH, Kligman A. Stratum corneum lipid removal by surfactants: relation to in vivo irritation Dermatol 1990; 181: 277-83.
• 18. Putnam FW. The İnteractions of proteins and synthetic detergents. Adv Protein Chem 1948; 4: 79-122.
• 19. Oser BL, Morgareidge K. Toxicologic studies with branched and linear alkylbenzene sulfonates in rats. Toxicol Appl Pharmacol 1965; 7: 819-25 .
• 20. Zaccone G, Cascio PL, Fasula S, Licata A. The effect of an anionic detergent on complex carbohydrates and enzyme activities in the epidermis of the cat fish heteropneustes fossilis. Histochem J 1985; 17: 453-66.
• 21. Lim C, Docter R, Visser TJ, Krenning EP, Bernard B, Toor M, Jong M, Hennemann G. Inhibition of thyroxine transport in to cultured rat hepatocytes by serum of nonuremic critically 3 patients. Effects of bilirubin and nonesterified fatty acids. J Clin Endocr Met 1993; 76 (15): 1165-72.
• 22. Moriyama R, Malino S. Effect of detergent on protein structure. Action of detergents on secondary and oligomeric structures of band 3 from bovine erythrocyte membrans. Biochem Bioph A 1985; 832: 135-41.
• 23. Misra V, Lal M, Chawla G, Viswanathan PN. Pathomorphological changes in gills of fish fingerlings (cirrhinamrigalaj by linear alkyl benzene sulfonate . Ecotoxicol Environ 1985; 10: 302-8.
• 24. Adachi K, Matsuhashi T, Nishizawa Y, Usukura J, Popinigis J, Wakabayashi T. Studies on urea synthesis in the liver of rats treated chronically with ethanol using perfused livers, isolated hepatocytes, and mitochondria. Biochem Pharmacol 1997; 50 (9): 1391-9.
• 25. Almdal TP, Vilstrup H. Strict insulin therapy normalues organ nitrogen contents and the capacity of urea nitrogen synthesis in experimental diabetes in rats. Diabetol 1988; 1 (31): 114-8.
• 26. Michael WR. Metabolism of linear alkylbenzene sulfonate and alkyl benzene sulfonate in albino rats. Toxicol Appl Pharmacol 1968; 12: 473-85.
• 27. Brosnan TJ, Brosnan M, Charron R, Nissim I. A Mass isotopomer study of urea and glutamine synthesis from n-labeled ammonia in the perfused rat liver. J Biol Chem 1996; 271 (27): 16199-207.
• 28. Mengi A. Biyokimya. İstanbul Üniv. Basımevi ve Film Merk. Yay No 1991; 12- 323.
• 29. Hayase K, Yanekawa G, Yokogoshi H, Yoshida A. Triiodothronine administration affects urea synthesis in rats. Am İnst Nut. 1990; 121 (7): 970-8.
• 30. Gollan J, Hammaker L, Licko V, Schmid. Bilirubin kinetics in intact rats and is,olated perfused liver. Evidence for hepatic deconjugation of bilirubin glucuronides. J Clin Invest 1981; 67: 1003-15.
• 31. Gordon ER, Goresky C. The formation of bilirubin diglucuronide by rat liver microsomal prepartions. Con J Biochem 1980; 58: 1302-10.
• 32. Mc Donagh A, Palma LA. Hepatic excretion of circulating bilirubin photoproducts in the gunn rat. J Clin İnvest 1980; 66: 1182-5.
• 33. Mengi A. Pratik biyokimya ve veteriner hekimliğinde kullanılan testler. İstanbul Üni. Vet Fak Yay 1994; 2: 6-198.
• 34. Fitzhugh G, Nelson A. Chronic oral toxicities of surface active agents. J of Am Pharm Assoc 1987; 37: 29-32.