Ratlarda Linear Alkil Benzen Sülfonatın Serum Ve Karaciğerdeki Enzim Aktiviteleri Üzerine Kronik Etkilerinin Araştırılması

Öz

Bu araştırmada ratlara oral olarak verilen Linear Alkil Benzen Sülfonat’ın LAS serum ve karaciğerdeki alanintransferaz ve aspartat transferaz aktiviteleri düzeyleri üzerine kronik etkileri incelenmiştir. Elde edilen bulgulara göre,LAS’ın %0.002’lik 0.14mg/kg ve %0.005’lik 0.35mg/kg dozlarının ratlarda kronik olarak herhangi bir toksisiteyeneden olmayacağı ve ratlar için LAS’ın kronik etkilerinin %0.01 0.7mg/kg ile %0.03 2.1mg/kg dozlarında ve 120.günden itibaren gerçekleştiği sonucuna varılmıştır

Anahtar Kelimeler

• Linear Alkilbenzen Sülfonat, Alanin Transferaz, Aspartat Transferaz

CHRONIC EFFECTS OF LINEAR ALKYL BENZENE SULPHONATE ON SERUM AND LIVER ENZYME ACTIVITES IN RATS

Abstract

In this study, the chronic effects of Linear Alkyl Benzene Sulphonate LAS given by oral route, were examinedon alanin transpherase and aspartate transpherase enzyme activities in serum and liver of rats. It was concludedthat LAS in doses of 0.002% 0.14 mg/kg and 0.005% 0.35 mg/kg may not create toxic effects in rats andchronic toxic effects of LAS for rats occur in doses of 0.01% 0.7 mg/kg and 0.03% 2.1 mg/kg and in 120thdaysfollowing the application

Keywords

• Linear Alkylbenzene Sulphonate, Alanin Transpherase, Aspartate Transpherase

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