Maternal Kanda Afp, Hcg Ve Ankonjuge Östriol Düzeylerinin Gebelik Komplikasyonları İle İlişkisi

Öz

Amaç: Bu çalışmada Ankara İli ve çevresindeki gebe populasyonunda, maternal kanda yüksek AFP, yüksek hCG, düşük AFP ve düşük ankonjuge östriol değerleri ile gebelik komplikasyonları arasındaki ilişkinin araştırılması amaçlanmıştır. Yöntem: Sağlık Bakanlığı, Ankara Numune Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği’nde üçlü tarama testi yapılan 951 hastanın, gebelik sırasındaki komplikasyon oranları retrospektif olarak incelenmiştir. Her gebeden venöz kan örneği alınarak hCG, uE3 ve AFP testleri Ankara Numune Hastanesi One cihazında kompetetif immunoassay yöntemi kullanılarak ölçülmüştür. Elde edilen sonuçlar lisanslı PRISCA programı kullanılarak, gebelik haftalarına göre daha önceden belirlenen düzeltilmiş ortancanın katları multiple of median: MoM değeri olarak rapor edilmiştir. Hastanın yaşı, ırkı, kilosu, sigara ve diyabet öyküsü, IVF gebelik, örnek alınma tarihi, ultrasonografi tarihindeki BPD bi-parietal diameter ölçümü veya son adet tarihine göre risk hesabı yapılmıştır. Maternal kanda yüksek AFP >2 MoM , yüksek HCG >2 MoM , düşük AFP 2 MoM , 21’inde düşük AFP

Anahtar Kelimeler

• Gebelik Komplikasyonları, AFP, hCG, Ankonjüge UE3

The Relationship Between Pregnancy Complications And Afp, Hcg And Unconjuge Estriol Level In Maternal Serum

Abstract

Objective: The aim of the study was to determine the relationship of pregnancy complications with high low AFP, high HCG and low estriol levels detected in maternal serum in the Ankara regions pregnancy population. Method: 951 patients who had undergone triple test during pregnancy for complication rates at T.C.S.B. Ankara Numune Education and Research Hospital were determined retrospectively. Venous blood samples were taken from each patient, Beta hCG, uE3 and AFP tests performed at Ankara Numune Hospital Biochemistry laboratory by using Immulite One® system which was based competetive immunassay methods. Obtained results reported corrected multiple of the median median multiple of: MoM values according to pregnancy weeks by using licenced computer program Prisca® . The risk calculation was made by Patient’s age, race, weight, smoking and diabetes, history of IVF pregnancies and sampling date, using either BPD biparietal diameter measurement at ultrasound date or last menstrual period.The patients with high AFP levels >2 MoM , high HCG levels >2 MoM , low AFP levels 2 MoM , 21 patients with low AFP

Keywords

• Pregnancy Complications, AFP, hCG, Unconjuge Estriol

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