Walker 256 tümörlü ratlarda Argininle takviye edilen diyetin hayatta kalmaya etkisi

Öz

Amaç: Bu çalışma Walker 256 tümörlü ratların %8’lik arginin içeren diyetle sağ kalım sürelerinin arttırılmasını değerlendirmek amacıyla yapılmıştır.Yöntem: Bu çalışma deneysel, rastgele ve çift kör metodla yapılmıştır. Deneyde ratlar 3 gruba ayrılmıştır. Birinci gruba placebo walker 256 tümör aşılanmasından 7 gün önce sonda yardımı ile su verilmiştir. İkinci grup tümör aşılamasından 48 saat sonra %8’lik arginin solüsyonu almıştır. Üçüncü grup ise tümör aşılamasından 7 gün önce %8’lik arginin solüsyonu ile beslenmeye başlanmıştır.Bulgular: Tümoral aşılamadan 7 gün önce beslenmeye başlayan üçüncü grup diğer iki gruba nazaran daha fazla hayatta kalmıştır. 21 gün p=0.0001 Aşılamadan 48 saat sonra beslenen grupta hayatta kalma süresi 20 gün p=0.0001 placebo grubuna nazaran daha fazladır.Sonuç: Sonuçlar göstermektedir ki Arginin takviyesi alan iki grup placebo grubuna nazaran hayatta kalma süresi açısından bundan fayda görmüşlerdir. Ayrıca arginin takviyesine tümör aşılamasından önce başlayan grupta bu etki daha fazladır

Anahtar Kelimeler

• Arginin, kanser, hayatta kalım, Walker 256 tümörü

Survival of rats with Walker 256 Tumor after oral suplementation of arginine in the diet

Abstract

Objective: This study was undertaken to assess the effect of L-arginine at 8% on extended survival of rats with Walker 256 tumor. Method: The study is experimental, randomized, double blind. The animals for this experiment were divided in 3 groups. The first group placebo received gavage with water, seven days before the inoculation of Walker 256 tumor. The second group received 8% L-arginine solution of caloric ingestion 48 hours after the tumoral inoculation. The third group received 8% L-arginine solution of total caloric ingestion, initiated seven days before the tumoral inoculation. Results: The third group, supplemented seven days before the tumoral inoculation, presented greater extended survival 21 days, p=0.0001 when compared to animals from the other two. Animals supplemented 48 hours after the tumoral inoculation presented greater extended survival 20 days, p=0.0001 when compared to the placebo group 19 days, p=0.0001 .Conclusion: The results suggest that both groups supplemented with 8% L-arginine presented beneficial results in respect to extended survival when compared to the placebo group, and better yet if the amino acid was administered before the tumoral inoculation

Keywords

• Arginine, cancer, survival, Walker 256 tumor

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