Akut Renal Kolik Ağrısı Olan Türk Hastalarda Kısa Süreli Metamizol Sodyum ile Diklofenak Sodyum tedavilerinin karşılaştırılması; Bir Çift Kör, Gözlemsel Çalışma

Öz

Amaç: Renal kolik ağrısı, acil servis başvurularının en sık nedenlerinden biridir. Metamizol sodyum ve diklofenak, ilaçların bulunduğu ülkelerde en yaygın kullanılan narkotik olmayan ilaçlardır. Bu çalışmanın amacı, Ankara’daki acil servislerde akut renal kolik ağrısının tedavisinde metamizol sodyum ve diklofenak’ın etkinliğini ve güvenliğini karşılaştırmaktır.Yöntem: Renal kolik ağrısı olan 88 hasta intramüsküler metamizol sodyum 1 g n=48 veya diklofenak sodyum 75 mg n=40 ile tedavi edildi. Ağrı şiddeti, ilaç uygulanmadan önce başlangıç düzeyi ve uygulandıktan 30, 60, 90 ve 120 dakika sonra, Görsel Analog Skala 0100 mm ve 5-Nokta Sözel Derecelendirme Ölçeği ile ölçüldü. Bulgular: Her iki tedavi grubu da yaş, cinsiyet ve başlangıçtaki ağrı şiddeti yönlerinden analiz edildiğinde homojendi. Her iki tedavi de iyi tolere edildi ve gözlenen yan etkilerin hiçbiri ciddi değildi. Metamizol sodyum grubunda beş, diklofenak grubunda ise üç hasta ek tedaviye ihtiyaç duydu. Ölçülen tüm zaman noktaları için gruplar arasındaki ortalama ağrı şiddeti farkı anlamlı değildi. Her iki ilaç için de hekim ve hasta değerlendirmeleri arasında anlamlı fark yoktu. Sonuç: Sonuçlarımız akut renal kolik tedavisinde i.m. 1 g metamizol sodyumun, iki saatlik gözlem dönemi için i.m. 75 mg diklofenak sodyum kadar etkili olduğunu göstermektedir

Anahtar Kelimeler

• Renal kolik, metamizol sodyum, diklofenak sodyum

Short-Term Use Of Metamizole Sodium Versus Diclofenac Sodium In Acute Renal Colic Pain In Turkish Patients; A Double-Blind, Observational Study

Abstract

Objective: Renal colic pain is one of the most frequent reasons for emergency department visits. Metamizole sodium and diclofenac are the most common used non-narcotic drugs in available countries. The objective of this study was to compare the effectiveness and safety of metamizole sodium and diclofenac in treatment of acute renal colic pain in emergency room services in Ankara, Turkey.Methods: Eighty-eight patients with renal colic were treated intramuscularly i.m. with metamizole sodium 1 g n=48 or diclofenac sodium 75 mg n=40 . Pain intensity was measured by using visual analogue scale 0-100 mm and 5-point verbal score before baseline and after 30, 60, 90 and 120 minutes of i.m. drug administration.Results: Both of the treatment groups were homogeneous when analyzed by age, sex and baseline pain intensity. Both treatments were well tolerated and none of the observed side effects were serious. Five patients in the metamizole sodium and three patients in the diclofenac group needed extra treatment. The average pain intensity difference between groups for all time points measured was not significantly different. There was no significant difference in physician and patient evaluations for both drugs. Sonuç: Sonuçlarımız akut renal kolik tedavisinde i.m. 1 g metamizol sodyumun, iki saatlik gözlem dönemi için i.m. 75 mg diklofenak sodyum kadar etkili olduğunu göstermektedir

Keywords

• Renal colic, metamizole sodium, diclofenac sodium

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