Hepatit B'li Hastalarda Artmış Ortalama Trombosit Hacmi, Eritrosit Dağılım Genişliği ve Trombosit / Eritrosit Dağılım Genişliği Oranı

Öz

Amaç: Hepatit B virüsü tüm dünyada önemli bir morbidite ve mortalite nedenidir. Son yıllardaki çalışmalarda kronik hepatit B’li hastalarda rutin hematolojik parametrelerden olan ortalama trombosit hacmi MPV ve eritrosit dağılım genişliği RDW seviyeleri sağlıklı kişilere göre anlamlı olarak yüksek bulunmuştur. Bu çalışmada Hepatit B yüzey antijeni HBsAg pozitif olgularda MPV, RDW ve RDW/Trombosit PLT eritrosit dağılım genişliği/trombosit oranı RPR ilişkisinin araştırılması amaçlanmıştır.Yöntem: 2011-2012 yılları arasında Antalya Halk Sağlığı Laboratuvarı’na başvuran hastalar retrospektif olarak incelemeye alındı. HBsAg pozitif olarak saptanan ve yaşları 17-82 arasında değişen 349’u kadın ve 213’ü erkek olmak üzere toplam 562 hasta çalışmaya alındı. Aynı dönemde yaklaşık 3:1 hasta/kontrol oranında sağlıklı kişilerin yaş ve cinsiyet ile eşleşen kontrol grubu oluşturuldu. Kontrol grubu, yaşları 18-76 arasında değişen 121 kadın ve 80 erkekten oluşturuldu. Hastaların eş zamanlı olarak alanin aminotransferaz ALT , aspartat aminotransferaz AST , PLT, MPV, RDW ve RPR düzeyleri incelendi. Results: Average age in the HBsAg positive group was found to be 42.07 ± 12.71 years. HbsAg negative control group had mean age of 41.21 ± 13.15 years. There was no statistically difference of age among patient and control groups p=0.367 . AST and ALT values in HBsAg positive patients were significantly higher than the control group p

Anahtar Kelimeler

• HBsAg, MPV, RDW, RPR oranı

Increased Mean Platelet Volume, Red Blood Cell Distribution Width and Platelet/ Red Blood Cell Distribution Width in Patients With Hepatitis B.

Abstract

Objective: Hepatitis B virus is a major cause of morbidity and mortality worldwide. In chronic hepatitis B patients, routine hematological parameters such as Mean Platelet Volume MPV , Red Cell Distribution Width RDW levels were found significantly higher than healthy persons in recent reports. The present study aimed to investigate the relationship of MPV, RDW and RDW / platelet PLT RPR in Hepatitis B surface antigen HBsAg positive cases.Methods: Patients were evaluated retrospectively between 2011-2012 years in Public Health Laboratory, Antalya. 562 cases of HBsAg positive patients of which were 349 women and 213 men aged between 17-82 years old enrolled the study. During the same period control group were recruited from healthy persons at patient/control ratio of approximately 3:1 with matching age and sex. Control group was consisted of 121 women and 80 men aged between 18-76 years old . At the same time alanine aminotransferase ALT , aspartate aminotransferase AST , PLT, MPV, RDW and RPR levels of patients were investigated

Keywords

• HBsAg, MPV, RDW, RPR oranı, Hepatit B

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