Şanlıurfa'da Yaşa Özgü Anti-Müllerian Hormon Nomogramı

Öz

Amaç: Antimüllerian hormon AMH seviyeleri genellikle yumurtalık rezervinin iyi bir öngörücüsü olarak kabul edilmektedir. Şanlıurfa, Türkiye’nin en yüksek doğurganlık oranına sahip ilidir. Bu çalışmanın amacı Şanlıurfa’daki infertilite şikâyeti olan hastaların serum AMH düzeylerinin yaşa özgü nomogramlarını belirlemek ve doğurganlıkla ilişkisini saptamaktır.Yöntem: Harran Üniversitesi Araştırma ve Uygulama Hastanesi infertilite polikliniğine müracaat eden ve AMH düzeyleri ölçülmüş olan hastaların kayıtları retrospektif olarak incelendi. Bu retrospektif çalışmaya Şubat 2017 ile Eylül 2018 arasında kayıtlı olan tüm hastalar dahil edildi. Çalışmaya toplam olarak 3667 hasta verisi dâhil edildi. AMH seviyelerinin yaşa özgü dağılımı tespit edildi. Çalışmaya dahil edilen hastaların serum AMH düzeyleri, aynı marka kitlere sahip bir C601 otoanalizöründe ECLIA yöntemi kullanılarak tek laboratuvarda rutin olarak saptanmış ve sonuçlar ng/mL olarak ifade edildi. Aşırı değerler >30 ng/mL değerlendirme dışında tutuldu ve birden fazla AMH ölçümlerinden yalnızca ilk AMH değeri nomograma dahil edildi. Bulgular: Histogram analizinde, AMH düzeylerinin 19 ve 23 yaşında iki tepe noktası gösterdiğini ve daha sonra azalan bir eğilim gösterdiğini tespit ettik. Serum AMH düzeyleri yaş ile negatif korelasyon gösterdi r = -0.518, p

Anahtar Kelimeler

• Antimüllerian hormon, yardımcı üreme teknikleri, kısırlık, over rezervi

Age-Specific Anti-Mullerian Hormone Nomogram in Şanlıurfa

Abstract

Objective: Antimullerian hormone AMH levels are generally considered a good predictor of ovarian reserve. Şanlıurfa, is the city with the highest fertility rate in Turkey. The aim of this study is to determine the age spesific serum AMH nomogram of the patients with infertility complaints in Şanlıurfa and its relationship with fertility.Methods: The records of patients who applied to Harran University Research and Application Hospital infertility outpatient clinic and whose AMH levels were measured were reviewed retrospectively. All patients registered between February 2017 and September 2018 were included in this retrospective study. A total of 3667 patient data were included in the study. Age-specific distribution of AMH levels was determined. Serum AMH levels of patients included in the study were routinely determined in a single laboratory using the ECLIA method in a C601 autoanalyser with the same brand kits, and the results were expressed as ng/mL. Excessive values > 30 ng/mL were excluded from evaluation and only the first AMH value among multiple AMH measurements was included in the nomogram.Results: In the histogram analysis, we found that AMH levels showed two peaks at the age of 19 and 23 and düzeyleri yaş ile negatif korelasyon gösterdi r = -0.518, p

Keywords

• Antimullerian hormone, in vitro fertilization, infertility, ovarian reserve

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